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Index > Protein center > HPGDS(Gene name) > Human
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  • HPGDS (Gene name),
  • Hematopoietic prostaglandin D synthase (Protein name ),  HPGDS_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    HPGDS(GSTS;PGDS;PTGDS2);
    Protein name:
    Hematopoietic prostaglandin D synthase(H-PGDS);
    Alternative:
    Prostaglandin-H2 D-isomerase;Glutathione-requiring prostaglandin D synthase;Glutathione-dependent PGD synthase;GST class-sigma;2.5.1.18;Glutathione S-transferase);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    199
    Sequence:
    50:
    MPNYKLTYFN | MRGRAEIIRY | IFAYLDIQYE | DHRIEQADWP | EIKSTLPFGK | 
    100:
    IPILEVDGLT | LHQSLAIARY | LTKNTDLAGN | TEMEQCHVDA | IVDTLDDFMS | 
    150:
    CFPWAEKKQD | VKEQMFNELL | TYNAPHLMQD | LDTYLGGREW | LIGNSVTWAD | 
    199:
    FYWEICSTTL | LVFKPDLLDN | HPRLVTLRKK | VQAIPAVANW | IKRRPQTKL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    MIM:
    KEGG:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human H-PGDS
    Cat.:
    E15054h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human H-PGDS
    MSDS:
    Please sign in first.
    ELISA Kit for Human H-PGDS
    Cat.:
    E15054c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human H-PGDS
    Cat.:
    E15054r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human H-PGDS
    MSDS:
    Please sign in first.
    CLIA Kit for Human H-PGDS
    Cat.:
    U15054h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human H-PGDS
    MSDS:
    Please sign in first.
    CLIA Kit for Human H-PGDS
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human H-PGDS
    Polyclonal Antibody for Human H-PGDS
    Polyclonal Antibody for Human H-PGDS
    Polyclonal Antibody for Human H-PGDS
    Monoclonal Antibody for Human H-PGDS
    Monoclonal Antibody for Human H-PGDS
    Monoclonal Antibody for Human H-PGDS
    Monoclonal Antibody for Human H-PGDS
    Protein for Human H-PGDS
    Protein for Human H-PGDS
    Protein for Human H-PGDS
    Protein for Human H-PGDS

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    References
    1. 1.
      "Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase."
      Kanaoka Y. , Fujimori K. , Kikuno R. , Sakaguchi Y. , Urade Y. , Hayaishi O.
      Eur. J. Biochem.267:3315-3322(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];FUNCTION;CATALYTIC ACTIVITY;COFACTOR;TISSUE SPECIFICITY
      tissue: Placenta.
    2. 2.
      "Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases."
      Jowsey I.R. , Thomson A.M. , Flanagan J.U. , Murdock P.R. , Moore G.B. , Meyer D.J. , Murphy G.J. , Smith S.A. , Hayes J.D.
      Biochem. J.359:507-516(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CATALYTIC ACTIVITY;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
      tissue: Placenta.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Substantia nigra.
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    7. 7.
      "Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester."
      Suzuki T. , Watanabe K. , Kanaoka Y. , Sato T. , Hayaishi O.
      Biochem. Biophys. Res. Commun.241:288-293(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;COFACTOR;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
      tissue: Megakaryocyte.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;COFACTOR;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Megakaryocyte.
    9. 9.
      "Mechanism of metal activation of human hematopoietic prostaglandin D synthase."
      Inoue T. , Irikura D. , Okazaki N. , Kinugasa S. , Matsumura H. , Uodome N. , Yamamoto M. , Kumasaka T. , Miyano M. , Kai Y. , Urade Y.
      Nat. Struct. Biol.10:291-296(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEXES WITH CALCIUM IONS; MAGNESIUM IONS AND GLUTATHIONE;FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;SUBUNIT;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF ASP-93; ASP-96 AND ASP-97
    10. 10.
      "First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase."
      Inoue T. , Okano Y. , Kado Y. , Aritake K. , Irikura D. , Uodome N. , Okazaki N. , Kinugasa S. , Shishitani H. , Matsumura H. , Kai Y. , Urade Y.
      J. Biochem.135:279-283(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH MAGNESIUM IONS AND THE SYNTHETIC INHIBITOR BSBT;FUNCTION;SUBUNIT;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
    11. 11.
      "Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase."
      Aritake K. , Kado Y. , Inoue T. , Miyano M. , Urade Y.
      J. Biol. Chem.281:15277-15286(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE; MAGNESIUM IONS AND THE SYNTHETIC INHIBITOR HQL-79;FUNCTION;CATALYTIC ACTIVITY
    12. 12.
      "Novel prostaglandin D synthase inhibitors generated by fragment-based drug design."
      Hohwy M. , Spadola L. , Lundquist B. , Hawtin P. , Dahmen J. , Groth-Clausen I. , Nilsson E. , Persdotter S. , von Wachenfeldt K. , Folmer R.H. , Edman K.
      J. Med. Chem.51:2178-2186(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEXES WITH SYNTHETIC INHIBITORS;SUBUNIT
    13. 13.
      "Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase."
      Weber J.E. , Oakley A.J. , Christ A.N. , Clark A.G. , Hayes J.D. , Hall R. , Hume D.A. , Board P.G. , Smythe M.L. , Flanagan J.U.
      Eur. J. Med. Chem.45:447-454(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) IN COMPLEX WITH SYNTHETIC INHIBITOR;CATALYTIC ACTIVITY;FUNCTION
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