HPGDS ELISA Kit for Human(Homo sapiens) | EIAab.comHPGDS ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HPGDS(Gene name) > Human

HPGDS (Gene name),

Hematopoietic prostaglandin D synthase (Protein name ), HPGDS_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HPGDS(GSTS;PGDS;PTGDS2);

Protein name:

Hematopoietic prostaglandin D synthase(H-PGDS);

Alternative:

2.5.1.18;Glutathione S-transferase);GST class-sigma;Glutathione-requiring prostaglandin D synthase;Glutathione-dependent PGD synthase;Prostaglandin-H2 D-isomerase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

199

Sequence:

50:

100:

150:

199:

FYWEICSTTL | LVFKPDLLDN | HPRLVTLRKK | VQAIPAVANW | IKRRPQTKL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O60760

UniGene:

Hs.128433

KEGG:

hsa:27306

STRING:

9606.ENSP00000295256

String:

O60760

MIM:

602598

Pfam:

PF00043

Uniprot:

O60760

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ELISA Kit for Human H-PGDS

Cat.:

E15054h

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96T

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ELISA Kit for Human H-PGDS

MSDS:

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ELISA Kit for Human H-PGDS

Cat.:

E15054c

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ELISA Kit for Human H-PGDS

Cat.:

E15054r

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CLIA Kit for Human H-PGDS

MSDS:

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CLIA Kit for Human H-PGDS

Cat.:

U15054h

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Packing:

96T

CLIA Kit for Human H-PGDS

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CLIA Kit for Human H-PGDS

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Polyclonal Antibody for Human H-PGDS

Monoclonal Antibody for Human H-PGDS

Protein for Human H-PGDS

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase."
Kanaoka Y. , Fujimori K. , Kikuno R. , Sakaguchi Y. , Urade Y. , Hayaishi O.
Eur. J. Biochem.267:3315-3322(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];FUNCTION;CATALYTIC ACTIVITY;COFACTOR;TISSUE SPECIFICITY
tissue: Placenta.
2.

"Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases."
Jowsey I.R. , Thomson A.M. , Flanagan J.U. , Murdock P.R. , Moore G.B. , Meyer D.J. , Murphy G.J. , Smith S.A. , Hayes J.D.
Biochem. J.359:507-516(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CATALYTIC ACTIVITY;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
tissue: Placenta.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Substantia nigra.
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
7.

"Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester."
Suzuki T. , Watanabe K. , Kanaoka Y. , Sato T. , Hayaishi O.
Biochem. Biophys. Res. Commun.241:288-293(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;COFACTOR;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
tissue: Megakaryocyte.
8.

"Prostaglandin D synthase in human megakaryoblastic cells."
Mahmud I. , Ueda N. , Yamaguchi H. , Yamashita R. , Yamamoto S. , Kanaoka Y. , Urade Y. , Hayaishi O.
J. Biol. Chem.272:28263-28266(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;COFACTOR;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Megakaryocyte.
9.

"Mechanism of metal activation of human hematopoietic prostaglandin D synthase."
Inoue T. , Irikura D. , Okazaki N. , Kinugasa S. , Matsumura H. , Uodome N. , Yamamoto M. , Kumasaka T. , Miyano M. , Kai Y. , Urade Y.
Nat. Struct. Biol.10:291-296(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEXES WITH CALCIUM IONS; MAGNESIUM IONS AND GLUTATHIONE;FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;SUBUNIT;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF ASP-93; ASP-96 AND ASP-97
10.

"First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase."
Inoue T. , Okano Y. , Kado Y. , Aritake K. , Irikura D. , Uodome N. , Okazaki N. , Kinugasa S. , Shishitani H. , Matsumura H. , Kai Y. , Urade Y.
J. Biochem.135:279-283(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH MAGNESIUM IONS AND THE SYNTHETIC INHIBITOR BSBT;FUNCTION;SUBUNIT;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
11.

"Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase."
Aritake K. , Kado Y. , Inoue T. , Miyano M. , Urade Y.
J. Biol. Chem.281:15277-15286(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE; MAGNESIUM IONS AND THE SYNTHETIC INHIBITOR HQL-79;FUNCTION;CATALYTIC ACTIVITY
12.

"Novel prostaglandin D synthase inhibitors generated by fragment-based drug design."
Hohwy M. , Spadola L. , Lundquist B. , Hawtin P. , Dahmen J. , Groth-Clausen I. , Nilsson E. , Persdotter S. , von Wachenfeldt K. , Folmer R.H. , Edman K.
J. Med. Chem.51:2178-2186(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEXES WITH SYNTHETIC INHIBITORS;SUBUNIT
13.

"Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase."
Weber J.E. , Oakley A.J. , Christ A.N. , Clark A.G. , Hayes J.D. , Hall R. , Hume D.A. , Board P.G. , Smythe M.L. , Flanagan J.U.
Eur. J. Med. Chem.45:447-454(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) IN COMPLEX WITH SYNTHETIC INHIBITOR;CATALYTIC ACTIVITY;FUNCTION

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