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Index > Protein center > Hsp90aa1(Gene name) > Mouse
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  • Hsp90aa1 (Gene name),
  • Heat shock protein HSP 90-alpha (Protein name ),  HS90A_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Hsp90aa1(Hsp86;Hsp86-1;Hspca);
    Protein name:
    Heat shock protein HSP 90-alpha;
    Alternative:
    Tumor-specific transplantation 86 kDa antigen(TSTA);Heat shock 86 kDa(HSP 86;HSP86);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34 (By similarity). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (By similarity). Interacts with CHORDC1 and DNAJC7.
    Function:
    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
    Subcellular Location:
    Cytoplasm Melanosome
    Protein Attributes:
    Sequence length:
    733
    Sequence:
    50:
    MPEETQTQDQ | PMEEEEVETF | AFQAEIAQLM | SLIINTFYSN | KEIFLRELIS | 
    100:
    NSSDALDKIR | YESLTDPSKL | DSGKELHINL | IPSKQDRTLT | IVDTGIGMTK | 
    150:
    ADLINNLGTI | AKSGTKAFME | ALQAGADISM | IGQFGVGFYS | AYLVAEKVTV | 
    200:
    ITKHNDDEQY | AWESSAGGSF | TVRTDTGEPM | GRGTKVILHL | KEDQTEYLEE | 
    250:
    RRIKEIVKKH | SQFIGYPITL | FVEKERDKEV | SDDEAEEKEE | KEEEKEKEEK | 
    300:
    ESDDKPEIED | VGSDEEEEEK | KDGDKKKKKK | IKEKYIDQEE | LNKTKPIWTR | 
    350:
    NPDDITNEEY | GEFYKSLTND | WEEHLAVKHF | SVEGQLEFRA | LLFVPRRAPF | 
    400:
    DLFENRKKKN | NIKLYVRRVF | IMDNCEELIP | EYLNFIRGVV | DSEDLPLNIS | 
    450:
    REMLQQSKIL | KVIRKNLVKK | CLELFTELAE | DKENYKKFYE | QFSKNIKLGI | 
    500:
    HEDSQNRKKL | SELLRYYTSA | SGDEMVSLKD | YCTRMKENQK | HIYFITGETK | 
    550:
    DQVANSAFVE | RLRKHGLEVI | YMIEPIDEYC | VQQLKEFEGK | TLVSVTKEGL | 
    600:
    ELPEDEEEKK | KQEEKKTKFE | NLCKIMKDIL | EKKVEKVVVS | NRLVTSPCCI | 
    650:
    VTSTYGWTAN | MERIMKAQAL | RDNSTMGYMA | AKKHLEINPD | HSIIETLRQK | 
    700:
    AEADKNDKSV | KDLVILLYET | ALLSSGFSLE | DPQTHANRIY | RMIKLGLGID | 
    733:
    EDDPTVDDTS | AAVTEEMPPL | EGDDDTSRME | EVD
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    KEGG:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    E0863b
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    Packing:
    96T
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    ELISA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    E0863h
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    MSDS:
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    96T
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    ELISA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    E0863r
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    96T
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    ELISA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    E0863m
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    MSDS:
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    96T
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    ELISA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    E0863p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Heat shock protein HSP 90-alpha
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    E0863c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    U0863h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    U0863p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    U0863m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    U0863c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    U0863r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Heat shock protein HSP 90-alpha
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    U0863b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    P0863Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Polyclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Polyclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    P0863Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    P0863Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Polyclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Monoclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Monoclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Monoclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Monoclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Monoclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Monoclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Monoclonal Antibody for Mouse Heat shock protein HSP 90-alpha
    Protein for Mouse Heat shock protein HSP 90-alpha
    Cat.:
    R0863h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Mouse Heat shock protein HSP 90-alpha
    Protein for Mouse Heat shock protein HSP 90-alpha
    Protein for Mouse Heat shock protein HSP 90-alpha
    Protein for Mouse Heat shock protein HSP 90-alpha
    Protein for Mouse Heat shock protein HSP 90-alpha
    Protein for Mouse Heat shock protein HSP 90-alpha

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Murine 86- and 84-kDa heat shock proteins, cDNA sequences, chromosome assignments, and evolutionary origins."
      Moore S.K. , Kozak C. , Robinson E.A. , Ullrich S.J. , Appella E.
      J. Biol. Chem.264:5343-5351(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
    2. 2.
      "Mapping of the mouse 86-kDa heat-shock protein expressed gene (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4, 9, and 11."
      Moore S.K. , Appella E. , Villar C.J. , Kozak C.A.
      Genomics10:1019-1029(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: BALB/c.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Retina.
    4. 4.
      "A mouse tumor-specific transplantation antigen is a heat shock-related protein."
      Ullrich S.J. , Robinson E.A. , Law L.W. , Willingham M. , Appella E.
      Proc. Natl. Acad. Sci. U.S.A.83:3121-3125(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-31
    5. 5.
      "The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo."
      Minami Y. , Kimura Y. , Kawasaki H. , Suzuki K. , Yahara I.
      Mol. Cell. Biol.14:1459-1464(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-12;HOMODIMERIZATION
    6. 6.
      "Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens."
      Hoffmann T. , Hovemann B.
      Gene74:491-501(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-356
    7. 7.
      Lubec G. , Kang S.U. , Klug S. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 47-58; 61-69; 75-84; 88-112; 154-173; 186-201; 210-224; 285-356; 369-401; 448-457; 491-511; 515-535; 548-561; 569-574; 593-632 AND 634-648
      strain: C57BL/6.
      strain: OF1.
      tissue: Brain.
      tissue: Hippocampus.
    8. 8.
      "High constitutive transcription of HSP86 gene in murine embryonal carcinoma cells."
      Legagneux V. , Mezger V. , Quelard C. , Barnier J.V. , Bensaude O. , Morange M.
      Differentiation41:42-48(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 460-733
    9. 9.
      "Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin."
      Silverstein A.M. , Galigniana M.D. , Chen M.S. , Owens-Grillo J.K. , Chinkers M. , Pratt W.B.
      J. Biol. Chem.272:16224-16230(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH NR3C1 AND FKBP4; PPID; PPP5C OR STIP1
    10. 10.
      "Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus."
      Galigniana M.D. , Radanyi C. , Renoir J.-M. , Housley P.R. , Pratt W.B.
      J. Biol. Chem.276:14884-14889(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH NR3C1 AND FKBP4
    11. 11.
      "A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins."
      Davies T.H. , Ning Y.M. , Sanchez E.R.
      J. Biol. Chem.277:4597-4600(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A HETEROMULTIMERIC COMPLEX WITH NR3C1 AND FKBP4 OR FKBP5;SUBCELLULAR LOCATION
    12. 12.
      "The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues."
      Lees-Miller S.P. , Anderson C.W.
      J. Biol. Chem.264:17275-17280(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-5 AND THR-7 BY PRKDC
    13. 13.
      "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."
      Giannakopoulos N.V. , Luo J.K. , Papov V. , Zou W. , Lenschow D.J. , Jacobs B.S. , Borden E.C. , Li J. , Virgin H.W. , Zhang D.E.
      Biochem. Biophys. Res. Commun.336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
    14. 14.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-493;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    16. 16.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-314;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    17. 17.
      "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
      J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    18. 18.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-58 AND LYS-84;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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