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Index > Protein center > HSF4(Gene name) > Human
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  • HSF4 (Gene name),
  • Heat shock factor protein 4 (Protein name ),  HSF4_HUMAN from NCBI database.
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  • Gene name:
    HSF4;
    Protein name:
    Heat shock factor protein 4(HSF 4;hHSF4);
    Alternative:
    Heat shock transcription factor 4(HSTF 4);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts with DUSP26, MAPK1, MAPK2 and MAP kinase p38.
    Function:
    DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    492
    Sequence:
    50:
    MQEAPAALPT | EPGPSPVPAF | LGKLWALVGD | PGTDHLIRWS | PSGTSFLVSD | 
    100:
    QSRFAKEVLP | QYFKHSNMAS | FVRQLNMYGF | RKVVSIEQGG | LLRPERDHVE | 
    150:
    FQHPSFVRGR | EQLLERVRRK | VPALRGDDGR | WRPEDLGRLL | GEVQALRGVQ | 
    200:
    ESTEARLREL | RQQNEILWRE | VVTLRQSHGQ | QHRVIGKLIQ | CLFGPLQAGP | 
    250:
    SNAGGKRKLS | LMLDEGSSCP | TPAKFNTCPL | PGALLQDPYF | IQSPLPETNL | 
    300:
    GLSPHRARGP | IISDIPEDSP | SPEGTRLSPS | SDGRREKGLA | LLKEEPASPG | 
    350:
    GDGEAGLALA | PNECDFCVTA | PPPLPVAVVQ | AILEGKGSFS | PEGPRNAQQP | 
    400:
    EPGDPREIPD | RGPLGLESGD | RSPESLLPPM | LLQPPQESVE | PAGPLDVLGP | 
    450:
    SLQGREWTLM | DLDMELSLMQ | PLVPERGEPE | LAVKGLNSPS | PGKDPTLGAP | 
    492:
    LLLDVQAALG | GPALGLPGAL | TIYSTPESRT | ASYLGPEASP | SP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human HSF 4
    Cat.:
    E9000m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human HSF 4
    Cat.:
    E9000h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HSF 4
    MSDS:
    Please sign in first.
    CLIA Kit for Human HSF 4
    MSDS:
    Please sign in first.
    CLIA Kit for Human HSF 4
    Cat.:
    U9000m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HSF 4
    Cat.:
    U9000h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human HSF 4
    Cat.:
    P9000Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HSF 4
    Polyclonal Antibody for Human HSF 4
    Cat.:
    P9000Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HSF 4
    Monoclonal Antibody for Human HSF 4
    Monoclonal Antibody for Human HSF 4
    Protein for Human HSF 4
    Protein for Human HSF 4
    Protein for Human HSF 4

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    Precision
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    Linearity
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    References
    1. 1.
      "HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator."
      Nakai A. , Tanabe M. , Kawazoe Y. , Inazawa J. , Morimoto R.I. , Nagata K.
      Mol. Cell. Biol.17:469-481(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM HSF4A)
      tissue: Heart.
    2. 2.
      "The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing."
      Tanabe M. , Sasai N. , Nagata K. , Liu X.-D. , Liu P.C.C. , Thiele D.J. , Nakai A.
      J. Biol. Chem.274:27845-27856(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM HSF4B);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-396 (ISOFORM HSF4A);ALTERNATIVE SPLICING;CHARACTERIZATION
    3. 3.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26."
      Hu Y. , Mivechi N.F.
      Mol. Cell. Biol.26:3282-3294(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUSP26; MAPK1; MAPK2 AND MAP KINASE P38;PTM
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-293;PHOSPHORYLATION AT SER-298;FUNCTION;MUTAGENESIS OF LYS-293 AND SER-298
    6. 6.
      "Human ALKBH4 interacts with proteins associated with transcription."
      Bjornstad L.G. , Meza T.J. , Otterlei M. , Olafsrud S.M. , Meza-Zepeda L.A. , Falnes P.O.
      PLoS ONE7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ALKBH4
    7. 7.
      "Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract."
      Bu L. , Jin Y. , Shi Y. , Chu R. , Ban A. , Eiberg H. , Andres L. , Jiang H. , Zheng G. , Qian M. , Cui B. , Xia Y. , Liu J. , Hu L. , Zhao G. , Hayden M.R. , Kong X.
      Nat. Genet.31:276-278(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CTRCT5 ASP-19; VAL-86; PRO-114 AND CYS-119;TISSUE SPECIFICITY
    8. 8.
      "Novel HSF4 mutation causes congenital total white cataract in a Chinese family."
      Ke T. , Wang Q.K. , Ji B. , Wang X. , Liu P. , Zhang X. , Tang Z. , Ren X. , Liu M.
      Am. J. Ophthalmol.142:298-303(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CTRCT5 HIS-73
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