HTRA1 ELISA Kit for Human(Homo sapiens) | EIAab.comHTRA1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HTRA1(Gene name) > Human

HTRA1 (Gene name),

Serine protease HTRA1 (Protein name ), HTRA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HTRA1(HTRA;PRSS11);

Protein name:

Serine protease HTRA1;

Alternative:

L56;High-temperature requirement A serine peptidase 1;Serine protease 11;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Protease that regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Represses signaling by TGF-beta family members.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

480

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

480:

VIKRESTLNM | VVRRGNEDIM | ITVIPEEIDP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q92743

Pfam:

PF00219

UniGene:

Hs.501280

String:

Q92743

STRING:

9606.ENSP00000357980

KEGG:

hsa:5654

MIM:

600142

Uniprot:

Q92743

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ELISA Kit for Human Serine protease HTRA1

Cat.:

E2002h

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Packing:

96T

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ELISA Kit for Human Serine protease HTRA1

Cat.:

E2002m

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Packing:

96T

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ELISA Kit for Human Serine protease HTRA1

Cat.:

E2002r

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MSDS:

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Packing:

96T

ELISA Kit for Human Serine protease HTRA1

Cat.:

E2002b

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MSDS:

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Packing:

96T

CLIA Kit for Human Serine protease HTRA1

Cat.:

U2002r

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MSDS:

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Packing:

96T

CLIA Kit for Human Serine protease HTRA1

Cat.:

U2002m

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MSDS:

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Packing:

96T

CLIA Kit for Human Serine protease HTRA1

Cat.:

U2002h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Serine protease HTRA1

Cat.:

U2002b

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Packing:

96T

Polyclonal Antibody for Human Serine protease HTRA1

Cat.:

P2002Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Serine protease HTRA1

Cat.:

P2002Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Serine protease HTRA1

Cat.:

P2002Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Serine protease HTRA1

Monoclonal Antibody for Human Serine protease HTRA1

Protein for Human Serine protease HTRA1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Primary structure of a putative serine protease specific for IGF-binding proteins."
Zumbrunn J. , Trueb B.
FEBS Lett.398:187-192(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
2.

"Genomic organization and promoter characterization of the human HTRA (PRSS11) gene."
Crowl R.M. , Luk D. , Milnamow M.
Submitted (1999-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage."
Hu S.I. , Carozza M. , Klein M. , Nantermet P. , Luk D. , Crowl R.M.
J. Biol. Chem.273:34406-34412(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-480;PROTEIN SEQUENCE OF 33-44;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF SER-328
tissue: Cartilage.
5.

"The serine protease HtrA1 is upregulated in the human placenta during pregnancy."
De Luca A. , De Falco M. , Fedele V. , Cobellis L. , Mastrogiacomo A. , Laforgia V. , Tuduce I.L. , Campioni M. , Giraldi D. , Paggi M.G. , Baldi A.
J. Histochem. Cytochem.52:885-892(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
6.

"The role of human HtrA1 in arthritic disease."
Grau S. , Richards P.J. , Kerr B. , Hughes C. , Caterson B. , Williams A.S. , Junker U. , Jones S.A. , Clausen T. , Ehrmann M.
J. Biol. Chem.281:6124-6129(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
7.

"HTRA1 promoter polymorphism in wet age-related macular degeneration."
Dewan A. , Liu M. , Hartman S. , Zhang S.S.-M. , Liu D.T.L. , Zhao C. , Tam P.O.S. , Chan W.M. , Lam D.S.C. , Snyder M. , Barnstable C. , Pang C.P. , Hoh J.
Science314:989-992(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ARMD7
8.

"A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration."
Yang Z. , Camp N.J. , Sun H. , Tong Z. , Gibbs D. , Cameron D.J. , Chen H. , Zhao Y. , Pearson E. , Li X. , Chien J. , DeWan A. , Harmon J. , Bernstein P.S. , Shridhar V. , Zabriskie N.A. , Hoh J. , Howes K. , more...
Science314:992-993(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ARMD7
9.

"The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein."
Campioni M. , Severino A. , Manente L. , Tuduce I.L. , Toldo S. , Caraglia M. , Crispi S. , Ehrmann M. , He X. , Maguire J. , De Falco M. , De Luca A. , Shridhar V. , Baldi A.
Mol. Cancer Res.8:1248-1260(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"Solution structure of the PDZ-domain of human protease HTRA 1 precursor."
RIKEN structural genomics initiative (RSGI)
Submitted (2008-04) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 367-480
11.

"Substrate-induced remodeling of the active site regulates human HTRA1 activity."
Truebestein L. , Tennstaedt A. , Monig T. , Krojer T. , Canellas F. , Kaiser M. , Clausen T. , Ehrmann M.
Nat. Struct. Mol. Biol.18:386-388(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 158-480;HOMOTRIMERIZATION;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-328
12.

"Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease."
Hara K. , Shiga A. , Fukutake T. , Nozaki H. , Miyashita A. , Yokoseki A. , Kawata H. , Koyama A. , Arima K. , Takahashi T. , Ikeda M. , Shiota H. , Tamura M. , Shimoe Y. , Hirayama M. , Arisato T. , Yanagawa S. , Tanaka A. , more...
N. Engl. J. Med.360:1729-1739(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CARASIL THR-252 AND MET-297;CHARACTERIZATION OF VARIANTS CARASIL THR-252 AND MET-297

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