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Index > Protein center > Htra1(Gene name) > Mouse
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  • Htra1 (Gene name),
  • Serine protease HTRA1 (Protein name ),  HTRA1_MOUSE from NCBI database.
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  • Gene name:
    Htra1(Htra;Prss11);
    Protein name:
    Serine protease HTRA1;
    Alternative:
    Serine protease 11;Serine protease 11;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Protease that regulate the availability of nsulin-like growth factors (IGFs) by cleaving IGF-binding proteins (By similarity). Represses signaling by TGF-beta family members.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    480
    Sequence:
    50:
    MQSLRTTLLS | LLLLLLAAPS | LALPSGTGRS | APAATVCPEH | CDPTRCAPPP | 
    100:
    TDCEGGRVRD | ACGCCEVCGA | LEGAACGLQE | GPCGEGLQCV | VPFGVPASAT | 
    150:
    VRRRAQAGLC | VCASSEPVCG | SDAKTYTNLC | QLRAASRRSE | KLRQPPVIVL | 
    200:
    QRGACGQGQE | DPNSLRHKYN | FIADVVEKIA | PAVVHIELYR | KLPFSKREVP | 
    250:
    VASGSGFIVS | EDGLIVTNAH | VVTNKNRVKV | ELKNGATYEA | KIKDVDEKAD | 
    300:
    IALIKIDHQG | KLPVLLLGRS | SELRPGEFVV | AIGSPFSLQN | TVTTGIVSTT | 
    350:
    QRGGKELGLR | NSDMDYIQTD | AIINYGNSGG | PLVNLDGEVI | GINTLKVTAG | 
    400:
    ISFAIPSDKI | KKFLTESHDR | QAKGKAVTKK | KYIGIRMMSL | TSSKAKELKD | 
    450:
    RHRDFPDVLS | GAYIIEVIPD | TPAEAGGLKE | NDVIISINGQ | SVVTANDVSD | 
    480:
    VIKKENTLNM | VVRRGNEDIV | ITVIPEEIDP | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Serine protease HTRA1
    Cat.:
    E2002h
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    96T
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    ELISA Kit for Mouse Serine protease HTRA1
    Cat.:
    E2002m
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    ELISA Kit for Mouse Serine protease HTRA1
    Cat.:
    E2002r
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    Packing:
    96T
    ELISA Kit for Mouse Serine protease HTRA1
    Cat.:
    E2002b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Serine protease HTRA1
    Cat.:
    U2002r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Serine protease HTRA1
    Cat.:
    U2002m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Serine protease HTRA1
    Cat.:
    U2002h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Serine protease HTRA1
    Cat.:
    U2002b
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Serine protease HTRA1
    Cat.:
    P2002Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Serine protease HTRA1
    Cat.:
    P2002Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Serine protease HTRA1
    Cat.:
    P2002Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Serine protease HTRA1
    Monoclonal Antibody for Mouse Serine protease HTRA1
    Monoclonal Antibody for Mouse Serine protease HTRA1
    Monoclonal Antibody for Mouse Serine protease HTRA1
    Monoclonal Antibody for Mouse Serine protease HTRA1
    Protein for Mouse Serine protease HTRA1
    Protein for Mouse Serine protease HTRA1
    Protein for Mouse Serine protease HTRA1
    Protein for Mouse Serine protease HTRA1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins."
      Oka C. , Tsujimoto R. , Kajikawa M. , Koshiba-Takeuchi K. , Ina J. , Yano M. , Tsuchiya A. , Ueta Y. , Soma A. , Kanda H. , Matsumoto M. , Kawaichi M.
      Development131:1041-1053(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH BMP4; TGFB2; TGFB1; ACTIVIN A AND GDF5;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;MUTAGENESIS OF SER-328
      strain: ICR.
      tissue: Brain.
    2. 2.
      "Mouse insulin-like growth factor binding protein 5-directed endopeptidase: structural assessment, evolutionary analysis, ovarian expression, hormonal regulation and cellular localization."
      Hourvitz A. , Hennebold J.D. , King G. , Negishi H. , Erickson G.F. , Roby J.A. , Mayo K.E. , Adashi E.Y.
      Submitted (1999-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6.
      tissue: Ovary.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-480
      strain: C57BL/6J.
    6. 6.
      "Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease."
      Murwantoko I. , Yano M. , Ueta Y. , Murasaki A. , Kanda H. , Oka C. , Kawaichi M.
      Biochem. J.381:895-904(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF PHE-171
    7. 7.
      "Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis."
      Tsuchiya A. , Yano M. , Tocharus J. , Kojima H. , Fukumoto M. , Kawaichi M. , Oka C.
      Bone37:323-336(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    8. 8.
      "HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival."
      Launay S. , Maubert E. , Lebeurrier N. , Tennstaedt A. , Campioni M. , Docagne F. , Gabriel C. , Dauphinot L. , Potier M.C. , Ehrmann M. , Baldi A. , Vivien D.
      Cell Death Differ.15:1408-1416(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    9. 9.
      "High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-beta family member growth differentiation factor 6."
      Zhang L. , Lim S.L. , Du H. , Zhang M. , Kozak I. , Hannum G. , Wang X. , Ouyang H. , Hughes G. , Zhao L. , Zhu X. , Lee C. , Su Z. , Zhou X. , Shaw R. , Geum D. , Wei X. , Zhu J. , more...
      J. Biol. Chem.287:1520-1526(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
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