Protein name:
Serine protease HTRA2, mitochondrial ;
Alternative:
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions (By similarity). The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.
Function:
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis.
Subcellular Location:
Mitochondrion intermembrane space
Mitochondrion membrane
Single-pass membrane protein
Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Protein Attributes:
50:
MAALRAGRGA | GWSLRGWRAL | WGGRWGKGPL | LTPDLRALLT | SGTPDPRTRV |
100:
TYGTPSFRAR | LSVGVPEPRT | CLRSRTSDLR | ARLIAGTPDP | RTPEDSGTPG |
150:
TRLRVWLAVA | LGAGGAVLLL | FWGGGRGPPA | VLASVLGSPP | TSPRSQYNFI |
200:
ADVVEKTAPA | VVYIEILGRH | PFSGREVPIS | NGSGFVVAAD | GLIVTNAHVV |
250:
ADRRRVRVRL | PSGDTYEAVV | TAVDPVADIA | TLRIQTKEPL | PTLPLGRSAD |
300:
VRQGEFVVAM | GSPFALQNTI | TSGIVSSAQR | PAKDLGLPQT | NVEYIQTDAA |
350:
IDFGNSGGPL | VNLDGEVIGV | NTMKVTSGIS | FAIPSDRLRE | FLHRGEKKNS |
400:
WFGISGSQRR | YIGVMMLTLT | PSILAELQLR | EPSFPDVQHG | VLIHKVILDS |
450:
PAHRAGLRPG | DVILAIGEQL | VQNAEDIYEA | VRTQSQLAVR | IRRGQETLTL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Bovine Serine protease HTRA2, mitochondrial
ELISA Kit for Bovine Serine protease HTRA2, mitochondrial
ELISA Kit for Bovine Serine protease HTRA2, mitochondrial
CLIA Kit for Bovine Serine protease HTRA2, mitochondrial
CLIA Kit for Bovine Serine protease HTRA2, mitochondrial
CLIA Kit for Bovine Serine protease HTRA2, mitochondrial
Polyclonal Antibody for Bovine Serine protease HTRA2, mitochondrial
Polyclonal Antibody for Bovine Serine protease HTRA2, mitochondrial
Polyclonal Antibody for Bovine Serine protease HTRA2, mitochondrial
Monoclonal Antibody for Bovine Serine protease HTRA2, mitochondrial
Monoclonal Antibody for Bovine Serine protease HTRA2, mitochondrial
Monoclonal Antibody for Bovine Serine protease HTRA2, mitochondrial
Protein for Bovine Serine protease HTRA2, mitochondrial
Protein for Bovine Serine protease HTRA2, mitochondrial
Protein for Bovine Serine protease HTRA2, mitochondrial
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Basal ganglia .