Htra2 ELISA Kit for Mouse(Mus musculus) | EIAab.comHtra2 ELISA Kit for Mouse(Mus musculus)

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Htra2 (Gene name),

Serine protease HTRA2, mitochondrial (Protein name ), HTRA2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Htra2(Omi;Prss25);

Protein name:

Serine protease HTRA2, mitochondrial;

Alternative:

Omi stress-regulated endoprotease;High temperature requirement protein A2(HtrA2);Serine proteinase OMI;Serine protease 25;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions (By similarity). The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.

Function:

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis.

Subcellular Location:

Mitochondrion intermembrane space Mitochondrion membrane Single-pass membrane protein Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with BID.

Protein Attributes:

Sequence length:

458

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

458:

YVTPEVTE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:64704

UniGene:

Mm.21880

Pfam:

PF13180

SMR:

Q9JIY5

Pfam:

PF00595

String:

Q9JIY5

Uniprot:

Q9JIY5

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ELISA Kit for Mouse Serine protease HTRA2, mitochondrial

Cat.:

E15152h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse Serine protease HTRA2, mitochondrial

Cat.:

E15152m

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Serine protease HTRA2, mitochondrial

Cat.:

E15152b

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Packing:

96T

CLIA Kit for Mouse Serine protease HTRA2, mitochondrial

Cat.:

U15152h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Serine protease HTRA2, mitochondrial

Cat.:

U15152m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Serine protease HTRA2, mitochondrial

Cat.:

U15152b

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Serine protease HTRA2, mitochondrial

Cat.:

P15152Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Serine protease HTRA2, mitochondrial

Cat.:

P15152Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Serine protease HTRA2, mitochondrial

Monoclonal Antibody for Mouse Serine protease HTRA2, mitochondrial

Protein for Mouse Serine protease HTRA2, mitochondrial

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response."
Gray C.W. , Ward R.V. , Karran E.H. , Turconi S. , Rowles A. , Viglienghi D. , Southan C. , Barton A. , Fantom K.G. , West A. , Savopoulos J.W. , Hassan N.J. , Clinkenbeard H. , Hanning C. , Amegadzie B. , Davis J.B. , Dingwall C. , Livi G.P. , more...
Eur. J. Biochem.267:5699-5710(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
tissue: Brain.
2.

"Characterization of the mouse homolog of Omi serine protease."
Faccio L. , Fusco C. , Zervos A.S.
Submitted (1999-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6J.
tissue: Embryo.
3.

"HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins."
Verhagen A.M. , Silke J. , Ekert P.G. , Pakusch M. , Kaufmann H. , Connolly L.M. , Day C.L. , Tikoo A. , Burke R. , Wrobel C. , Moritz R.L. , Simpson R.J. , Vaux D.L.
J. Biol. Chem.277:445-454(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;MUTAGENESIS OF ALA-134; ALA-137 AND SER-306

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