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Index > Protein center > IL36RN(Gene name) > Mouse
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  • IL36RN (Gene name),
  • Interleukin-36 receptor antagonist protein (Protein name ),  I36RA_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL36RN(Fil1d;Il1f5;Il1h3;Il1hy1);
    Protein name:
    Interleukin-36 receptor antagonist protein;
    Alternative:
    Interleukin-1 delta(IL-1 delta);Interleukin-1 HY1(IL-1HY1);Interleukin-1 homolog 3(IL-1H3);Interleukin-1 family member 5(IL-1F5);Interleukin-1-like protein 1(IL-1L1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    156
    Sequence:
    50:
    MMVLSGALCF | RMKDSALKVL | YLHNNQLLAG | GLHAEKVIKG | EEISVVPNRA | 
    100:
    LDASLSPVIL | GVQGGSQCLS | CGTEKGPILK | LEPVNIMELY | LGAKESKSFT | 
    150:
    FYRRDMGLTS | SFESAAYPGW | FLCTSPEADQ | PVRLTQIPED | PAWDAPITDF | 
    156:
    YFQQCD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Interleukin-36 receptor antagonist protein
    ELISA Kit for Mouse Interleukin-36 receptor antagonist protein
    CLIA Kit for Mouse Interleukin-36 receptor antagonist protein
    CLIA Kit for Mouse Interleukin-36 receptor antagonist protein
    Polyclonal Antibody for Mouse Interleukin-36 receptor antagonist protein
    Polyclonal Antibody for Mouse Interleukin-36 receptor antagonist protein
    Monoclonal Antibody for Mouse Interleukin-36 receptor antagonist protein
    Monoclonal Antibody for Mouse Interleukin-36 receptor antagonist protein
    Protein for Mouse Interleukin-36 receptor antagonist protein
    Protein for Mouse Interleukin-36 receptor antagonist protein

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities."
      Barton J.L. , Herbst R. , Bosisio D. , Higgins L. , Nicklin M.J.H.
      Eur. J. Immunol.30:3299-3308(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Identification and initial characterization of four novel members of the interleukin-1 family."
      Kumar S. , McDonnell P.C. , Lehr R. , Tierney L. , Tzimas M.N. , Griswold D.E. , Capper E.A. , Tal-Singer R. , Wells G.I. , Doyle M.L. , Young P.R.
      J. Biol. Chem.275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
      Debets R. , Timans J.C. , Homey B. , Zurawski S. , Sana T.R. , Lo S. , Wagner J. , Edwards G. , Clifford T. , Menon S. , Bazan J.F. , Kastelein R.A.
      J. Immunol.167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Stomach.
      tissue: Tongue.
    5. 5.
      "Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation."
      Blumberg H. , Dinh H. , Trueblood E.S. , Pretorius J. , Kugler D. , Weng N. , Kanaly S.T. , Towne J.E. , Willis C.R. , Kuechle M.K. , Sims J.E. , Peschon J.J.
      J. Exp. Med.204:2603-2614(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    6. 6.
      "IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8."
      Costelloe C. , Watson M. , Murphy A. , McQuillan K. , Loscher C. , Armstrong M.E. , Garlanda C. , Mantovani A. , O'Neill L.A. , Mills K.H. , Lynch M.A.
      J. Neurochem.105:1960-1969(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."
      Towne J.E. , Renshaw B.R. , Douangpanya J. , Lipsky B.P. , Shen M. , Gabel C.A. , Sims J.E.
      J. Biol. Chem.286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CLEAVAGE OF INITIATOR METHIONINE
    9. 9.
      "High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity."
      Dunn E.F. , Gay N.J. , Bristow A.F. , Gearing D.P. , O'Neill L.A.J. , Pei X.Y.
      Biochemistry42:10938-10944(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 3-156;DISULFIDE BOND
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