IGFBP1 ELISA Kit for Human(Homo sapiens) | EIAab.comIGFBP1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > IGFBP1(Gene name) > Human

IGFBP1 (Gene name),

Insulin-like growth factor-binding protein 1 (Protein name ), IBP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IGFBP1(IBP1);

Protein name:

Insulin-like growth factor-binding protein 1(IBP-1;IGF-binding protein 1;IGFBP-1);

Alternative:

Placental protein 12(PP12);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds equally well IGF1 and IGF2.

Function:

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

259

Sequence:

50:

100:

150:

200:

250:

259:

CQIYFNVQN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.642938

Pfam:

PF00219

KEGG:

hsa:3484

MIM:

146730

String:

P08833

SMR:

P08833

STRING:

9606.ENSP00000275525

Uniprot:

P08833

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ELISA Kit for Human IBP-1

Cat.:

E0052r

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96T

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ELISA Kit for Human IBP-1

Cat.:

E0052m

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96T

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ELISA Kit for Human IBP-1

Cat.:

E0052p

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96T

ELISA Kit for Human IBP-1

Cat.:

E0052b

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96T

ELISA Kit for Human IBP-1

Cat.:

E0052h

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96T

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CLIA Kit for Human IBP-1

Cat.:

U0052h

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96T

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CLIA Kit for Human IBP-1

Cat.:

U0052b

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Packing:

96T

CLIA Kit for Human IBP-1

Cat.:

U0052m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human IBP-1

Cat.:

U0052r

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human IBP-1

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U0052p

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96T

Polyclonal Antibody for Human IBP-1

Cat.:

P0052Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IBP-1

Cat.:

P0052Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IBP-1

Cat.:

P0052Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IBP-1

Monoclonal Antibody for Human IBP-1

Protein for Human IBP-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)."
Brinkman A. , Groffen C. , Kortleve D.J. , Geurts A. , Drop S.L.S.
EMBO J.7:2417-2423(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
2.

"Cloning, characterization, and expression of a human insulin-like growth factor binding protein."
Brewer M.T. , Stetler G.L. , Squires C.H. , Thompson R.C. , Busby W.H. Jr. , Clemmons D.R.
Biochem. Biophys. Res. Commun.152:1289-1297(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Decidua.
3.

"Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin."
Grundmann U. , Nerlich C. , Bohn H. , Rein T.
Nucleic Acids Res.16:8711-8711(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
4.

"Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA."
Julkunen M. , Koistinen R. , Aalto-Setala K. , Seppala M. , Janne O.A. , Kontula K.
FEBS Lett.236:295-302(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Decidua.
5.

"Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors."
Lee Y.-L. , Hintz R.L. , James P.M. , Lee P.D.K. , Shively J.E. , Powell D.R.
Mol. Endocrinol.2:404-411(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein."
Cubbage M.L. , Suwanichkul A. , Powell D.R.
Mol. Endocrinol.3:846-851(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Organization of the gene encoding the insulin-like growth factor binding protein IBP-1."
Brinkman A. , Groffen C.A. , Kortleve D.J. , Drop S.L.
Biochem. Biophys. Res. Commun.157:898-907(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7."
Ehrenborg E. , Larsson C. , Stern I. , Janson M. , Powell D.R. , Luthman H.
Genomics12:497-502(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Liver.
9.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
10.

NIEHS SNPs program
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-183 AND MET-253
11.

"Human chromosome 7: DNA sequence and biology."
Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-253
tissue: Skin.
14.

"Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms."
Dolcini L. , Sala A. , Campagnoli M. , Labo S. , Valli M. , Visai L. , Minchiotti L. , Monaco H.L. , Galliano M.
FEBS J.276:6033-6046(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-53; 95-152 AND 182-208;CLEAVAGE OF INITIATOR METHIONINE;PHOSPHORYLATION AT SER-120; SER-123; SER-126; SER-144 AND SER-194;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Amniotic fluid.
15.

"Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning."
Luthman H. , Soederling-Barros J. , Persson B. , Engberg C. , Stern I. , Lake M. , Franzen S.A. , Israelsson M. , Raden B. , Lindgren B. , Hjelmqvist L. , Enerbaeck S. , Carlsson P. , Bjursell G. , Povoa G. , Hall K. , Joernvall H.
Eur. J. Biochem.180:259-265(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 141-259;PROTEIN SEQUENCE OF 26-259
tissue: Amniotic fluid.
16.

"Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions."
Busby W.H. Jr. , Klapper D.G. , Clemmons D.R.
J. Biol. Chem.263:14203-14210(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-53
17.

"Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability."
Brinkman A. , Kortlrve D.J. , Schuller A.G.P. , Zwarthoff E.C. , Drop S.L.S.
FEBS Lett.291:264-268(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
18.

"Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101."
Jones J.I. , Busby W.H. Jr. , Wright G. , Smith C.E. , Kimack N.M. , Clemmons D.R.
J. Biol. Chem.268:1125-1131(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-126; SER-144 AND SER-194;PARTIAL PROTEIN SEQUENCE
19.

"The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry."
Neumann G.M. , Bach L.A.
J. Biol. Chem.274:14587-14594(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
20.

"Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid."
Sala A. , Capaldi S. , Campagnoli M. , Faggion B. , Labo S. , Perduca M. , Romano A. , Carrizo M.E. , Valli M. , Visai L. , Minchiotti L. , Galliano M. , Monaco H.L.
J. Biol. Chem.280:29812-29819(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 172-251;PARTIAL PROTEIN SEQUENCE;FUNCTION;PHOSPHORYLATION;DISULFIDE BONDS
21.

"Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins."
Sitar T. , Popowicz G.M. , Siwanowicz I. , Huber R. , Holak T.A.
Proc. Natl. Acad. Sci. U.S.A.103:13028-13033(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 166-259 IN COMPLEX WITH IGFBP4 AND IGF1;DISULFIDE BONDS

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