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Index > Protein center > IGFBP2(Gene name) > Human
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  • IGFBP2 (Gene name),
  • Insulin-like growth factor-binding protein 2 (Protein name ),  IBP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    IGFBP2(BP2;IBP2);
    Protein name:
    Insulin-like growth factor-binding protein 2(IBP-2;IGF-binding protein 2;IGFBP-2);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds IGF2 more than IGF1.
    Function:
    Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    325
    Sequence:
    50:
    MLPRVGCPAL | PLPPPPLLPL | LLLLLGASGG | GGGARAEVLF | RCPPCTPERL | 
    100:
    AACGPPPVAP | PAAVAAVAGG | ARMPCAELVR | EPGCGCCSVC | ARLEGEACGV | 
    150:
    YTPRCGQGLR | CYPHPGSELP | LQALVMGEGT | CEKRRDAEYG | ASPEQVADNG | 
    200:
    DDHSEGGLVE | NHVDSTMNML | GGGGSAGRKP | LKSGMKELAV | FREKVTEQHR | 
    250:
    QMGKGGKHHL | GLEEPKKLRP | PPARTPCQQE | LDQVLERIST | MRLPDERGPL | 
    300:
    EHLYSLHIPN | CDKHGLYNLK | QCKMSLNGQR | GECWCVNPNT | GKLIQGAPTI | 
    325:
    RGDPECHLFY | NEQQEARGVH | TQRMQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    MIM:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human IBP-2
    Cat.:
    E0053r
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human IBP-2
    Cat.:
    E0053m
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human IBP-2
    Cat.:
    E0053b
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human IBP-2
    Cat.:
    E0053c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human IBP-2
    Cat.:
    E0053p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human IBP-2
    Cat.:
    E0053h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human IBP-2
    Cat.:
    U0053h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human IBP-2
    Cat.:
    U0053b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IBP-2
    Cat.:
    U0053m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IBP-2
    Cat.:
    U0053r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IBP-2
    Cat.:
    U0053p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IBP-2
    Cat.:
    U0053c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human IBP-2
    Polyclonal Antibody for Human IBP-2
    Cat.:
    P0053Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IBP-2
    Cat.:
    P0053Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IBP-2
    Polyclonal Antibody for Human IBP-2
    Polyclonal Antibody for Human IBP-2
    Cat.:
    P0053Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IBP-2
    Monoclonal Antibody for Human IBP-2
    Monoclonal Antibody for Human IBP-2
    Monoclonal Antibody for Human IBP-2
    Monoclonal Antibody for Human IBP-2
    Monoclonal Antibody for Human IBP-2
    Protein for Human IBP-2
    Protein for Human IBP-2
    Protein for Human IBP-2
    Protein for Human IBP-2
    Protein for Human IBP-2
    Protein for Human IBP-2

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    References
    1. 1.
      "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)."
      Binkert C. , Landwehr J. , Mary J.L. , Schwander J. , Heinrich G.
      EMBO J.8:2497-2502(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fetal liver.
    2. 2.
      "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia."
      Zapf J. , Kiefer M. , Merryweather J. , Musiarz F. , Bauer D. , Born W. , Fischer J.A. , Froesch E.R.
      J. Biol. Chem.265:14892-14898(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 37-74
    3. 3.
      "Structure and localization of the human insulin-like growth factor-binding protein 2 gene."
      Ehrenborg E. , Vilhelmsdotter S. , Bajalica S. , Larsson C. , Sterm I. , Koch J. , Brondum-Nielsen K. , Luthman H.
      Biochem. Biophys. Res. Commun.176:1250-1255(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    4. 4.
      "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)."
      Agarwal N. , Hsieh C.L. , Sills D. , Swaroop M. , Desai B. , Francke U. , Swaroop A.
      Exp. Eye Res.52:549-561(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Retina.
    5. 5.
      "Structure of the human insulin-like growth factor binding protein-2 gene."
      Binkert C. , Margot J.B. , Landwehr J. , Heinrich G. , Schwander J.
      Mol. Endocrinol.6:826-836(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    6. 6.
      "Full-length cDNA libraries and normalization."
      Li W.B. , Gruber C. , Jessee J. , Polayes D.
      Submitted (2004-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    7. 7.
      NIEHS SNPs program
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ASP-137
    8. 8.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Ovary.
      tissue: Uterus.
    10. 10.
      "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species."
      Roghani M. , Segovia B. , Whitechurch O. , Binoux M.
      Growth Regul.1:125-130(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 40-58;INTERACTION WITH IGF2;GLYCOSYLATION
      tissue: Cerebrospinal fluid.
    11. 11.
      "Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence."
      Zhou J. , Li W. , Kamei H. , Duan C.
      PLoS ONE3:E3926-E3926(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IGF1-BINDING;DOMAIN;MUTAGENESIS OF 216-LYS--ARG-219 AND ASP-303
    12. 12.
      "Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)."
      Kuang Z. , Yao S. , Keizer D.W. , Wang C.C. , Bach L.A. , Forbes B.E. , Wallace J.C. , Norton R.S.
      J. Mol. Biol.364:690-704(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 220-325;DISULFIDE BONDS
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