ICOS ELISA Kit for Human(Homo sapiens) | EIAab.comICOS ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ICOS(Gene name) > Human

ICOS (Gene name),

Inducible T-cell costimulator (Protein name ), ICOS_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ICOS(AILIM);

Protein name:

Inducible T-cell costimulator;

Alternative:

Activation-inducible lymphocyte immunomediatory molecule;

CD:

CD278;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked.

Function:

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Subcellular Location:

Isoform 2 Secreted

Protein Attributes:

Sequence length:

199

Sequence:

50:

100:

150:

199:

VVVCILGCIL | ICWLTKKKYS | SSVHDPNGEY | MFMRAVNTAK | KSRLTDVTL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9Y6W8

UniGene:

Hs.56247

SMR:

Q9Y6W8

MIM:

604558

STRING:

9606.ENSP00000319476

KEGG:

hsa:29851

Uniprot:

Q9Y6W8

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ELISA Kit for Human Inducible T-cell costimulator

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E15375r

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ELISA Kit for Human Inducible T-cell costimulator

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E15375b

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ELISA Kit for Human Inducible T-cell costimulator

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E15375h

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96T

ELISA Kit for Human Inducible T-cell costimulator

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E15375m

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96T

ELISA Kit for Human Inducible T-cell costimulator

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E15375d

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96T

CLIA Kit for Human Inducible T-cell costimulator

Cat.:

U15375m

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96T

CLIA Kit for Human Inducible T-cell costimulator

Cat.:

U15375d

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96T

CLIA Kit for Human Inducible T-cell costimulator

Cat.:

U15375h

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96T

CLIA Kit for Human Inducible T-cell costimulator

Cat.:

U15375r

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Packing:

96T

CLIA Kit for Human Inducible T-cell costimulator

Cat.:

U15375b

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96T

Polyclonal Antibody for Human Inducible T-cell costimulator

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P15375Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Inducible T-cell costimulator

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P15375Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Inducible T-cell costimulator

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P15375Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Inducible T-cell costimulator

Protein for Human Inducible T-cell costimulator

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28."
Hutloff A. , Dittrich A.M. , Beier K.C. , Eljaschewitsch B. , Kraft R. , Anagnostopoulos I. , Kroczek R.A.
Nature397:263-266(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1);PROTEIN SEQUENCE OF 192-198;FUNCTION;SUBUNIT;TISSUE SPECIFICITY
2.

"Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family."
Tezuka K. , Tsuji T. , Hirano D. , Tamatani T. , Sakamaki K. , Kobayashi Y. , Kamada M.
Biochem. Biophys. Res. Commun.276:335-345(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1);TISSUE SPECIFICITY
tissue: Blood.
3.

"Characterization of human inducible costimulator ligand expression and function."
Aicher A. , Hayden-Ledbetter M. , Brady W.A. , Pezzutto A. , Richter G. , Magaletti D. , Buckwalter S. , Ledbetter J.A. , Clark E.A.
J. Immunol.164:4689-4696(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
tissue: Thymus.
4.

"Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches."
Ling V. , Wu P.W. , Finnerty H.F. , Agostino M.J. , Graham J.R. , Chen S. , Jussiff J.M. , Fisk G.J. , Miller C.P. , Collins M.
Genomics78:155-168(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
5.

"Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation."
Haaning Andersen A.D. , Lange M. , Lillevang S.T.
Tissue Antigens61:276-285(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
6.

Todd J.A.
Submitted (2002-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Blood.
8.

"Induction, binding specificity and function of human ICOS."
Beier K.C. , Hutloff A. , Dittrich A.M. , Heuck C. , Rauch A. , Buechner K. , Ludewig B. , Ochs H.D. , Mages H.W. , Kroczek R.A.
Eur. J. Immunol.30:3707-3717(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;GLYCOSYLATION;SUBUNIT;INDUCTION;TISSUE SPECIFICITY
9.

"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency."
Grimbacher B. , Hutloff A. , Schlesier M. , Glocker E. , Warnatz K. , Draeger R. , Eibel H. , Fischer B. , Schaeffer A.A. , Mages H.W. , Kroczek R.A. , Peter H.H.
Nat. Immunol.4:261-268(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CVID1

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