EIF2S1 ELISA Kit for Human(Homo sapiens) | EIAab.comEIF2S1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > EIF2S1(Gene name) > Human

EIF2S1 (Gene name),

Eukaryotic translation initiation factor 2 subunit 1 (Protein name ), IF2A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

EIF2S1(EIF2A);

Protein name:

Eukaryotic translation initiation factor 2 subunit 1;

Alternative:

Eukaryotic translation initiation factor 2 subunit alpha(eIF-2-alpha;eIF-2A;eIF-2alpha);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Interacts with ABCF1 isoform 2. Associates with ribosomes.

Function:

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Subcellular Location:

Cytoplasmic granule The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules.

Protein Attributes:

Sequence length:

315

Sequence:

50:

100:

150:

200:

250:

300:

315:

DGDDDAEEME | AKAED

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1965

MIM:

603907

UniGene:

Hs.151777

STRING:

9606.ENSP00000256383

SMR:

P05198

String:

P05198

Pfam:

PF07541

Uniprot:

P05198

FOR

ELISA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

E11451h

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96T

ELISA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

E11451b

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96T

ELISA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

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ELISA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

E11451m

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96T

ELISA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

E11451p

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96T

ELISA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

E11451c

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96T

ELISA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

E11451r

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96T

CLIA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

U11451p

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Packing:

96T

CLIA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

MSDS:

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CLIA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

U11451b

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Packing:

96T

CLIA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

U11451h

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MSDS:

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Packing:

96T

CLIA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

U11451c

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MSDS:

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Packing:

96T

CLIA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

U11451r

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MSDS:

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Packing:

96T

CLIA Kit for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

U11451m

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96T

Polyclonal Antibody for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

P11451Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

P11451Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Eukaryotic translation initiation factor 2 subunit 1

Cat.:

P11451Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Eukaryotic translation initiation factor 2 subunit 1

Monoclonal Antibody for Human Eukaryotic translation initiation factor 2 subunit 1

Protein for Human Eukaryotic translation initiation factor 2 subunit 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA."
Ernst H. , Duncan R.F. , Hershey J.W.B.
J. Biol. Chem.262:1206-1212(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fibroblast.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
3.

"Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L."
Langland J.O. , Jacobs B.L.
Virology324:419-429(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION STATE REGULATION BY VACCINIA VIRUS PROTEIN E3
4.

"The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2."
Paytubi S. , Morrice N.A. , Boudeau J. , Proud C.G.
Biochem. J.409:223-231(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ABCF1;ASSOCIATION WITH RIBOSOMES
5.

"Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules."
Montero H. , Rojas M. , Arias C.F. , Lopez S.
J. Virol.82:1496-1504(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION STATE REGULATION BY ROTAVIRUS A
6.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
7.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-141;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.

"Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha."
Nonato M.C. , Widom J. , Clardy J.
J. Biol. Chem.277:17057-17061(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-183
10.

"Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B."
Ito T. , Marintchev A. , Wagner G.
Structure12:1693-1704(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 5-303

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