Protein name:
Eukaryotic translation initiation factor 2 subunit 3-like protein;
Alternative:
Eukaryotic translation initiation factor 2 subunit gamma A(eIF-2-gamma A;eIF-2gA);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterotrimer composed of an alpha, a beta and a gamma chain.
Function:
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Subcellular Location:
N/A
Protein Attributes:
50:
MAGGEAGVTL | GQPHLSRQDL | TTLDVTKLTP | LSHEVISRQA | TINIGTIGHV |
100:
AHGKSTVVKA | ISGVHTVRFK | NELERNITIK | LGYANAKIYQ | LDDPSCPRPE |
150:
CYRSCGSSMP | DEFPTDIPGT | KGNFRLVRHV | SFVDCPGHDI | LMATMLNGAA |
200:
VMDAALLLIA | GNESCPQPQT | SEHLAAIEIM | KLKHILILQN | KIDLVKERQA |
250:
KEQYEQILAF | VQGTVAEGAP | IIPISAQLKY | NIEVVCEYIV | KKIPVPPRDF |
300:
TSEPRLIVIR | SFDVNKPGCE | VDDLKGGVAG | GSILKGVLKV | GQETEVRPGI |
350:
VSKDSEGKLM | CKSIFSKIVS | LFAEHNDLQY | AAPGGLIGVG | TKIDPTLCRA |
400:
DRMVGQILGA | VGALPEIFTE | LEISYFLLRR | LLGVRTEGDK | KAAKVQKLSK |
450:
NEVLMVNIGS | LSTGGRVSAV | KADLGKIVLT | NPVCTEVGEK | IALSRRVEKH |
472:
WRLIGWGQIR | RGVTIKPTVD | DD

Vaild Sequence:
Related Databases
Uniprot: