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Index > Protein center > EIF5B(Gene name) > Human
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  • EIF5B (Gene name),
  • Eukaryotic translation initiation factor 5B (Protein name ),  IF2P_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EIF5B(IF2;KIAA0741);
    Protein name:
    Eukaryotic translation initiation factor 5B(eIF-5B);
    Alternative:
    Translation initiation factor IF-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ANXA5 in a calcium and phospholipid-dependent manner.
    Function:
    Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    1220
    Sequence:
    50:
    MGKKQKNKSE | DSTKDDIDLD | ALAAEIEGAG | AAKEQEPQKS | KGKKKKEKKK | 
    100:
    QDFDEDDILK | ELEELSLEAQ | GIKADRETVA | VKPTENNEEE | FTSKDKKKKG | 
    150:
    QKGKKQSFDD | NDSEELEDKD | SKSKKTAKPK | VEMYSGSDDD | DDFNKLPKKA | 
    200:
    KGKAQKSNKK | WDGSEEDEDN | SKKIKERSRI | NSSGESGDES | DEFLQSRKGQ | 
    250:
    KKNQKNKPGP | NIESGNEDDD | ASFKIKTVAQ | KKAEKKERER | KKRDEEKAKL | 
    300:
    RKLKEKEELE | TGKKDQSKQK | ESQRKFEEET | VKSKVTVDTG | VIPASEEKAE | 
    350:
    TPTAAEDDNE | GDKKKKDKKK | KKGEKEEKEK | EKKKGPSKAT | VKAMQEALAK | 
    400:
    LKEEEERQKR | EEEERIKRLE | ELEAKRKEEE | RLEQEKRERK | KQKEKERKER | 
    450:
    LKKEGKLLTK | SQREARARAE | ATLKLLQAQG | VEVPSKDSLP | KKRPIYEDKK | 
    500:
    RKKIPQQLES | KEVSESMELC | AAVEVMEQGV | PEKEETPPPV | EPEEEEDTED | 
    550:
    AGLDDWEAMA | SDEETEKVEG | NKVHIEVKEN | PEEEEEEEEE | EEEDEESEEE | 
    600:
    EEEEGESEGS | EGDEEDEKVS | DEKDSGKTLD | KKPSKEMSSD | SEYDSDDDRT | 
    650:
    KEERAYDKAK | RRIEKRRLEH | SKNVNTEKLR | APIICVLGHV | DTGKTKILDK | 
    700:
    LRHTHVQDGE | AGGITQQIGA | TNVPLEAINE | QTKMIKNFDR | ENVRIPGMLI | 
    750:
    IDTPGHESFS | NLRNRGSSLC | DIAILVVDIM | HGLEPQTIES | INLLKSKKCP | 
    800:
    FIVALNKIDR | LYDWKKSPDS | DVAATLKKQK | KNTKDEFEER | AKAIIVEFAQ | 
    850:
    QGLNAALFYE | NKDPRTFVSL | VPTSAHTGDG | MGSLIYLLVE | LTQTMLSKRL | 
    900:
    AHCEELRAQV | MEVKALPGMG | TTIDVILING | RLKEGDTIIV | PGVEGPIVTQ | 
    950:
    IRGLLLPPPM | KELRVKNQYE | KHKEVEAAQG | VKILGKDLEK | TLAGLPLLVA | 
    1000:
    YKEDEIPVLK | DELIHELKQT | LNAIKLEEKG | VYVQASTLGS | LEALLEFLKT | 
    1050:
    SEVPYAGINI | GPVHKKDVMK | ASVMLEHDPQ | YAVILAFDVR | IERDAQEMAD | 
    1100:
    SLGVRIFSAE | IIYHLFDAFT | KYRQDYKKQK | QEEFKHIAVF | PCKIKILPQY | 
    1150:
    IFNSRDPIVM | GVTVEAGQVK | QGTPMCVPSK | NFVDIGIVTS | IEINHKQVDV | 
    1200:
    AKKGQEVCVK | IEPIPGESPK | MFGRHFEATD | ILVSKISRQS | IDALKDWFRD | 
    1220:
    EMQKSDWQLI | VELKKVFEII | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    SMR:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human eIF-5B
    ELISA Kit for Human eIF-5B
    ELISA Kit for Human eIF-5B
    CLIA Kit for Human eIF-5B
    CLIA Kit for Human eIF-5B
    CLIA Kit for Human eIF-5B
    Polyclonal Antibody for Human eIF-5B
    Polyclonal Antibody for Human eIF-5B
    Polyclonal Antibody for Human eIF-5B
    Monoclonal Antibody for Human eIF-5B
    Monoclonal Antibody for Human eIF-5B
    Monoclonal Antibody for Human eIF-5B
    Protein for Human eIF-5B
    Protein for Human eIF-5B
    Protein for Human eIF-5B

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    References
    1. 1.
      "Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2 and its interaction with HIV-1 matrix."
      Wilson S.A. , Sieiro-Vazquez C. , Edwards N.J. , Iourin O. , Byles E.D. , Kotsopoulou E. , Adamson C.S. , Kingsman S.M. , Kingsman A.J. , Martin-Rendon E.
      Biochem. J.342:97-103(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-522
      tissue: Cervix carcinoma.
    2. 2.
      "Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2."
      Lee J.H. , Choi S.K. , Roll-Mecak A. , Burley S.K. , Dever T.E.
      Proc. Natl. Acad. Sci. U.S.A.96:4342-4347(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];MUTAGENESIS OF VAL-640; HIS-706 AND ASP-759;CHARACTERIZATION;VARIANT THR-522
      tissue: Testis.
    3. 3.
      "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 4.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      Bienvenut W.V. , Waridel P. , Quadroni M.
      Submitted (2009-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 9-33; 77-94; 106-122; 180-197; 206-224; 285-298; 425-436; 629-644; 653-683; 695-713; 749-757; 766-777; 882-902; 1000-1015; 1044-1055; 1096-1120 AND 1175-1185;PHOSPHORYLATION AT SER-190;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Cervix carcinoma.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-1220
      tissue: Testis.
    7. 7.
      "Characterization of 16 novel human genes showing high similarity to yeast sequences."
      Stanchi F. , Bertocco E. , Toppo S. , Dioguardi R. , Simionati B. , Cannata N. , Zimbello R. , Lanfranchi G. , Valle G.
      Yeast18:69-80(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 833-1220
    8. 8.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-113; SER-164 AND SER-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
      Giorgianni F. , Zhao Y. , Desiderio D.M. , Beranova-Giorgianni S.
      Electrophoresis28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Prostate cancer.
    10. 10.
      "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R. , Zhu Z. , Chan K.C. , Issaq H.J. , Dimitrov D.S. , Veenstra T.D.
      J. Proteome Res.6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
      J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: T-cell.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-113; TYR-134; SER-135; SER-137; SER-164; SER-182; SER-183; SER-186; SER-190; THR-301; SER-547; SER-560; SER-588 AND SER-595;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G. , Ye M. , Zhou H. , Jiang X. , Feng S. , Jiang X. , Tian R. , Wan D. , Zou H. , Gu J.
      Proteomics8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-113 AND SER-164;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    15. 15.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; TYR-134; SER-135; SER-137; SER-164; SER-182; SER-183; SER-186; SER-190 AND SER-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    17. 17.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; SER-135; SER-137; SER-164; SER-182; SER-186; SER-190; SER-214; THR-301; SER-588; SER-589; SER-591 AND SER-595;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-113; TYR-134; SER-135; SER-137; SER-164; SER-171; SER-214 AND THR-498;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-522;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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