Eif4e ELISA Kit for Rat(Rattus norvegicus) | EIAab.comEif4e ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Eif4e(Gene name) > Rat

Eif4e (Gene name),

Eukaryotic translation initiation factor 4E (Protein name ), IF4E_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Eif4e;

Protein name:

Eukaryotic translation initiation factor 4E(eIF-4E;eIF4E);

Alternative:

mRNA cap-binding protein;eIF-4F 25 kDa subunit;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Nonphosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1. Interacts with NGDN and PIWIL2.

Function:

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

217

Sequence:

50:

100:

150:

200:

217:

ADTATKSGST | TKNRFVV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P63074

UniGene:

Rn.11275

Pfam:

PF01652

String:

P63074

KEGG:

rno:117045

Uniprot:

P63074

FOR

ELISA Kit for Rat eIF-4E

CLIA Kit for Rat eIF-4E

Polyclonal Antibody for Rat eIF-4E

Monoclonal Antibody for Rat eIF-4E

Protein for Rat eIF-4E

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Abundant expression of translation initiation factor EIF-4E in post-meiotic germ cells of the rat testis."
Miyagi Y. , Kerr S. , Sugiyama A. , Asai A. , Shibuya M. , Fujimoto H. , Kuchino Y.
Lab. Invest.73:890-898(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;PHOSPHORYLATION;TISSUE SPECIFICITY
tissue: Testis.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
3.

"PHAS-I as a link between mitogen-activated protein kinase and translation initiation."
Lin T.-A. , Kong X. , Haystead T.A.J. , Pause A. , Belsham G.J. , Sonenberg N. , Lawrence J.C. Jr.
Science266:653-656(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EIF4EBP1

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