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Index > Protein center > IFIH1(Gene name) > Human
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  • IFIH1 (Gene name),
  • Interferon-induced helicase C domain-containing protein 1 (Protein name ),  IFIH1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    IFIH1(MDA5;RH116);
    Protein name:
    Interferon-induced helicase C domain-containing protein 1;
    Alternative:
    Helicase with 2 CARD domains(Helicard);Clinically amyopathic dermatomyositis autoantigen 140 kDa(CADM-140 autoantigen);Melanoma differentiation-associated protein 5(MDA-5);Interferon-induced with helicase C domain protein 1;RNA helicase-DEAD box protein 116(RLR-2);Murabutide down-regulated protein;RNA helicase-DEAD box protein 116;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MAVS. Interacts with V protein of Simian virus 5, Human parainfluenza virus 2, Mumps virus, Sendai virus and Hendra virus. Binding to paramyxoviruses V proteins prevents IFN-beta induction, and the further establishment of an antiviral state. Interacts with PCBP2. Interacts with NLRC5.
    Function:
    RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential for the production of interferons in response to picornaviruses.
    Subcellular Location:
    Cytoplasm Nucleus May be found in the nucleus, during apoptosis.
    Protein Attributes:
    Sequence length:
    1025
    Sequence:
    50:
    MSNGYSTDEN | FRYLISCFRA | RVKMYIQVEP | VLDYLTFLPA | EVKEQIQRTV | 
    100:
    ATSGNMQAVE | LLLSTLEKGV | WHLGWTREFV | EALRRTGSPL | AARYMNPELT | 
    150:
    DLPSPSFENA | HDEYLQLLNL | LQPTLVDKLL | VRDVLDKCME | EELLTIEDRN | 
    200:
    RIAAAENNGN | ESGVRELLKR | IVQKENWFSA | FLNVLRQTGN | NELVQELTGS | 
    250:
    DCSESNAEIE | NLSQVDGPQV | EEQLLSTTVQ | PNLEKEVWGM | ENNSSESSFA | 
    300:
    DSSVVSESDT | SLAEGSVSCL | DESLGHNSNM | GSDSGTMGSD | SDEENVAARA | 
    350:
    SPEPELQLRP | YQMEVAQPAL | EGKNIIICLP | TGSGKTRVAV | YIAKDHLDKK | 
    400:
    KKASEPGKVI | VLVNKVLLVE | QLFRKEFQPF | LKKWYRVIGL | SGDTQLKISF | 
    450:
    PEVVKSCDII | ISTAQILENS | LLNLENGEDA | GVQLSDFSLI | IIDECHHTNK | 
    500:
    EAVYNNIMRH | YLMQKLKNNR | LKKENKPVIP | LPQILGLTAS | PGVGGATKQA | 
    550:
    KAEEHILKLC | ANLDAFTIKT | VKENLDQLKN | QIQEPCKKFA | IADATREDPF | 
    600:
    KEKLLEIMTR | IQTYCQMSPM | SDFGTQPYEQ | WAIQMEKKAA | KEGNRKERVC | 
    650:
    AEHLRKYNEA | LQINDTIRMI | DAYTHLETFY | NEEKDKKFAV | IEDDSDEGGD | 
    700:
    DEYCDGDEDE | DDLKKPLKLD | ETDRFLMTLF | FENNKMLKRL | AENPEYENEK | 
    750:
    LTKLRNTIME | QYTRTEESAR | GIIFTKTRQS | AYALSQWITE | NEKFAEVGVK | 
    800:
    AHHLIGAGHS | SEFKPMTQNE | QKEVISKFRT | GKINLLIATT | VAEEGLDIKE | 
    850:
    CNIVIRYGLV | TNEIAMVQAR | GRARADESTY | VLVAHSGSGV | IEHETVNDFR | 
    900:
    EKMMYKAIHC | VQNMKPEEYA | HKILELQMQS | IMEKKMKTKR | NIAKHYKNNP | 
    950:
    SLITFLCKNC | SVLACSGEDI | HVIEKMHHVN | MTPEFKELYI | VRENKALQKK | 
    1000:
    CADYQINGEI | ICKCGQAWGT | MMVHKGLDLP | CLKIRNFVVV | FKNNSTKKQY | 
    1025:
    KKWVELPITF | PNLDYSECCL | FSDED
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    Pfam:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Interferon-induced helicase C domain-containing protein 1
    Cat.:
    E2803h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Interferon-induced helicase C domain-containing protein 1
    Cat.:
    E2803m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Interferon-induced helicase C domain-containing protein 1
    Cat.:
    U2803m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Interferon-induced helicase C domain-containing protein 1
    Cat.:
    U2803h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Interferon-induced helicase C domain-containing protein 1
    Cat.:
    P2803Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Interferon-induced helicase C domain-containing protein 1
    Cat.:
    P2803Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Interferon-induced helicase C domain-containing protein 1
    Monoclonal Antibody for Human Interferon-induced helicase C domain-containing protein 1
    Protein for Human Interferon-induced helicase C domain-containing protein 1
    Protein for Human Interferon-induced helicase C domain-containing protein 1

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    References
    1. 1.
      "mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties."
      Kang D.-C. , Gopalkrishnan R.V. , Wu Q. , Jankowsky E. , Pyle A.M. , Fisher P.B.
      Proc. Natl. Acad. Sci. U.S.A.99:637-642(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Melanoma.
    2. 2.
      "A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication."
      Cocude C. , Truong M.-J. , Billaut-Mulot O. , Delsart V. , Darcissac E. , Capron A. , Mouton Y. , Bahr G.M.
      J. Gen. Virol.84:3215-3225(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT ARG-843
      tissue: Spleen.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS ARG-843 AND THR-946
      tissue: Uterus.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 475-1025 (ISOFORM 1);VARIANTS ARG-843 AND THR-946
    5. 5.
      "Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation."
      Kovacsovics M. , Martinon F. , Micheau O. , Bodmer J.-L. , Hofmann K. , Tschopp J.
      Curr. Biol.12:838-843(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-251 AND GLU-444;TISSUE SPECIFICITY
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    7. 7.
      "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter."
      Andrejeva J. , Childs K.S. , Young D.F. , Carlos T.S. , Stock N. , Goodbourn S. , Randall R.E.
      Proc. Natl. Acad. Sci. U.S.A.101:17264-17269(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PARAMYXOVIRUSES V PROTEIN
    8. 8.
      "IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction."
      Kawai T. , Takahashi K. , Sato S. , Coban C. , Kumar H. , Kato H. , Ishii K.J. , Takeuchi O. , Akira S.
      Nat. Immunol.6:981-988(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAVS/IPS1
    9. 9.
      "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus."
      Meylan E. , Curran J. , Hofmann K. , Moradpour D. , Binder M. , Bartenschlager R. , Tschopp J.
      Nature437:1167-1172(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAVS/IPS1
    10. 10.
      "RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease."
      Sato S. , Hoshino K. , Satoh T. , Fujita T. , Kawakami Y. , Fujita T. , Kuwana M.
      Arthritis Rheum.60:2193-2200(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CLINICALLY AMYOPATHIC DERMATOMYOSITIS;IDENTIFICATION AS CADM-140 AUTOANTIGEN
    11. 11.
      "Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2."
      Bamming D. , Horvath C.M.
      J. Biol. Chem.284:9700-9712(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Activation of MDA5 requires higher-order RNA structures generated during virus infection."
      Pichlmair A. , Schulz O. , Tan C.P. , Rehwinkel J. , Kato H. , Takeuchi O. , Akira S. , Way M. , Schiavo G. , Reis e Sousa C.
      J. Virol.83:10761-10769(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4."
      You F. , Sun H. , Zhou X. , Sun W. , Liang S. , Zhai Z. , Jiang Z.
      Nat. Immunol.10:1300-1308(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PCBP2
    14. 14.
      "NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways."
      Cui J. , Zhu L. , Xia X. , Wang H.Y. , Legras X. , Hong J. , Ji J. , Shen P. , Zheng S. , Chen Z.J. , Wang R.F.
      Cell141:483-496(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRC5
    15. 15.
      "The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling."
      Chen R. , Zhang L. , Zhong B. , Tan B. , Liu Y. , Shu H.B.
      Cell Res.20:802-811(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP17L2
    16. 16.
      "The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody."
      Nakashima R. , Imura Y. , Kobayashi S. , Yukawa N. , Yoshifuji H. , Nojima T. , Kawabata D. , Ohmura K. , Usui T. , Fujii T. , Okawa K. , Mimori T.
      Rheumatology49:433-440(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CLINICALLY AMYOPATHIC DERMATOMYOSITIS;IDENTIFICATION AS CADM-140 AUTOANTIGEN;IDENTIFICATION BY MASS SPECTROMETRY
    17. 17.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Immune signaling by RIG-I-like receptors."
      Loo Y.M. , Gale M. Jr.
      Immunity34:680-692(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    20. 20.
      "RIG-I-like receptors: cytoplasmic sensors for non-self RNA."
      Kato H. , Takahasi K. , Fujita T.
      Immunol. Rev.243:91-98(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    21. 21.
      "Innate immune responses in human monocyte-derived dendritic cells are highly dependent on the size and the 5' phosphorylation of RNA molecules."
      Jiang M. , Osterlund P. , Sarin L.P. , Poranen M.M. , Bamford D.H. , Guo D. , Julkunen I.
      J. Immunol.187:1713-1721(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    23. 23.
      "DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling."
      Miyashita M. , Oshiumi H. , Matsumoto M. , Seya T.
      Mol. Cell. Biol.31:3802-3819(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDX60
    24. 24.
      "MDA5 is SUMOylated by PIAS2? in the upregulation of type I interferon signaling."
      Fu J. , Xiong Y. , Xu Y. , Cheng G. , Tang H.
      Mol. Immunol.48:415-422(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION;INTERACTION WITH PIAS2-BETA
    25. 25.
      "2 methylate or not 2 methylate: viral evasion of the type I interferon response."
      Garcia-Sastre A.
      Nat. Immunol.12:114-115(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    26. 26.
      "Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5."
      Zuest R. , Cervantes-Barragan L. , Habjan M. , Maier R. , Neuman B.W. , Ziebuhr J. , Szretter K.J. , Baker S.C. , Barchet W. , Diamond M.S. , Siddell S.G. , Ludewig B. , Thiel V.
      Nat. Immunol.12:137-143(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    27. 27.
      "Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition."
      Peisley A. , Lin C. , Wu B. , Orme-Johnson M. , Liu M. , Walz T. , Hur S.
      Proc. Natl. Acad. Sci. U.S.A.108:21010-21015(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    28. 28.
      "A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region."
      Smyth D.J. , Cooper J.D. , Bailey R. , Field S. , Burren O. , Smink L.J. , Guja C. , Ionescu-Tirgoviste C. , Widmer B. , Dunger D.B. , Savage D.A. , Walker N.M. , Clayton D.G. , Todd J.A.
      Nat. Genet.38:617-619(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-946;ASSOCIATION WITH IDDM19
    29. 29.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IDDM19;VARIANTS IDDM19 PHE-372; THR-452 AND HIS-779;CHARACTERIZATION OF VARIANTS IDDM19 PHE-372; THR-452 AND HIS-779
    30. 30.
      "Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling."
      Rice G.I. , del Toro Duany Y. , Jenkinson E.M. , Forte G.M. , Anderson B.H. , Ariaudo G. , Bader-Meunier B. , Baildam E.M. , Battini R. , Beresford M.W. , Casarano M. , Chouchane M. , Cimaz R. , Collins A.E. , Cordeiro N.J. , Dale R.C. , Davidson J.E. , De Waele L. , more...
      Nat. Genet.46:503-509(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IDDM19;VARIANTS IDDM19 GLY-337; VAL-393; ARG-495; GLN-720; HIS-779 AND CYS-779;CHARACTERIZATION OF VARIANTS IDDM19 GLY-337; VAL-393; ARG-495; GLN-720; HIS-779 AND CYS-779
    31. 31.
      "Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5."
      Li X. , Lu C. , Stewart M. , Xu H. , Strong R.K. , Igumenova T. , Li P.
      Arch. Biochem. Biophys.488:23-33(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 893-1017 IN COMPLEX WITH ZINC IONS
    32. 32.
      "Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors."
      Takahasi K. , Kumeta H. , Tsuduki N. , Narita R. , Shigemoto T. , Hirai R. , Yoneyama M. , Horiuchi M. , Ogura K. , Fujita T. , Inagaki F.
      J. Biol. Chem.284:17465-17474(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 896-1025 IN COMPLEX WITH ZINC IONS
    33. 33.
      "Human dech-box RNA helicase mda5 (melanoma differentiation-associated protein 5), dech-domain."
      Structural genomics consortium (SGC)
      Submitted (2009-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 277-490
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