Ifih1 ELISA Kit for Mouse(Mus musculus) | EIAab.comIfih1 ELISA Kit for Mouse(Mus musculus)

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Ifih1 (Gene name),

Interferon-induced helicase C domain-containing protein 1 (Protein name ), IFIH1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ifih1;

Protein name:

Interferon-induced helicase C domain-containing protein 1;

Alternative:

Interferon induced with helicase C domain protein 1;Helicase with 2 CARD domains(Helicard);RIG-I-like receptor 2(RLR-2);Melanoma differentiation-associated protein 5(MDA-5);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with MAVS. Interacts with V protein of Sendai virus. Binding to paramyxoviruses V proteins prevents IFN-beta induction, and the further establishment of an antiviral state (By similarity). Interacts with PCBP2 (By similarity). Interacts with NLRC5.

Function:

RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA (By similarity). Essential for the production of interferons in response to picornaviruses.

Subcellular Location:

Cytoplasm Nucleus May be found in the nucleus, during apoptosis.

Protein Attributes:

Sequence length:

1025

Sequence:

50:

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1000:

1025:

KKWVELPIRF | PDLDYSEYCL | YSDED

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:71586

SMR:

Q8R5F7

Pfam:

PF00619

String:

Q8R5F7

UniGene:

Mm.136224

Uniprot:

Q8R5F7

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ELISA Kit for Mouse Interferon-induced helicase C domain-containing protein 1

Cat.:

E2803h

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96T

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ELISA Kit for Mouse Interferon-induced helicase C domain-containing protein 1

Cat.:

E2803m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Interferon-induced helicase C domain-containing protein 1

Cat.:

U2803m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Interferon-induced helicase C domain-containing protein 1

Cat.:

U2803h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Interferon-induced helicase C domain-containing protein 1

Cat.:

P2803Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Interferon-induced helicase C domain-containing protein 1

Cat.:

P2803Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Interferon-induced helicase C domain-containing protein 1

Protein for Mouse Interferon-induced helicase C domain-containing protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation."
Kovacsovics M. , Martinon F. , Micheau O. , Bodmer J.-L. , Hofmann K. , Tschopp J.
Curr. Biol.12:838-843(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;CLEAVAGE SITES;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
2.

Kovacsovics M. , Martinon F. , Micheau O. , Bodmer J.-L. , Hofmann K. , Tschopp J.
Curr. Biol.12:1633-1633(2002)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

"mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties."
Kang D.-C. , Gopalkrishnan R.V. , Wu Q. , Jankowsky E. , Pyle A.M. , Fisher P.B.
Proc. Natl. Acad. Sci. U.S.A.99:637-642(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6J.
tissue: Bone marrow.
tissue: Cecum.
tissue: Thymus.
tissue: Vagina.
5.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: FVB/N.
tissue: Mammary gland.
7.

"Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses."
Kato H. , Takeuchi O. , Sato S. , Yoneyama M. , Yamamoto M. , Matsui K. , Uematsu S. , Jung A. , Kawai T. , Ishii K.J. , Yamaguchi O. , Otsu K. , Tsujimura T. , Koh C.S. , Reis e Sousa C. , Matsuura Y. , Fujita T. , Akira S.
Nature441:101-105(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645 AND SER-648;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
9.

"Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity."
Loo Y.M. , Fornek J. , Crochet N. , Bajwa G. , Perwitasari O. , Martinez-Sobrido L. , Akira S. , Gill M.A. , Garcia-Sastre A. , Katze M.G. , Gale M. Jr.
J. Virol.82:335-345(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Activation of MDA5 requires higher-order RNA structures generated during virus infection."
Pichlmair A. , Schulz O. , Tan C.P. , Rehwinkel J. , Kato H. , Takeuchi O. , Akira S. , Way M. , Schiavo G. , Reis e Sousa C.
J. Virol.83:10761-10769(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Immune signaling by RIG-I-like receptors."
Loo Y.M. , Gale M. Jr.
Immunity34:680-692(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
13.

"RIG-I-like receptors: cytoplasmic sensors for non-self RNA."
Kato H. , Takahasi K. , Fujita T.
Immunol. Rev.243:91-98(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
14.

"Retinoic acid-inducible gene-I-like receptors."
Onoguchi K. , Yoneyama M. , Fujita T.
J. Interferon Cytokine Res.31:27-31(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
15.

"2 methylate or not 2 methylate: viral evasion of the type I interferon response."
Garcia-Sastre A.
Nat. Immunol.12:114-115(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
16.

"Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5."
Zuest R. , Cervantes-Barragan L. , Habjan M. , Maier R. , Neuman B.W. , Ziebuhr J. , Szretter K.J. , Baker S.C. , Barchet W. , Diamond M.S. , Siddell S.G. , Ludewig B. , Thiel V.
Nat. Immunol.12:137-143(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA."
Berke I.C. , Modis Y.
EMBO J.31:1714-1726(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 545-697;SUBUNIT

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