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Index > Protein center > IFITM3(Gene name) > Human
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  • IFITM3 (Gene name),
  • Interferon-induced transmembrane protein 3 (Protein name ),  IFM3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    IFITM3;
    Protein name:
    Interferon-induced transmembrane protein 3;
    Alternative:
    Interferon-inducible protein 1-8U;Interferon-inducible protein 1-8U(DSPA2b);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SPP1; the interaction reduces OPN expression.
    Function:
    IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    133
    Sequence:
    50:
    MNHTVQTFFS | PVNSGQPPNY | EMLKEEHEVA | VLGAPHNPAP | PTSTVIHIRS | 
    100:
    ETSVPDHVVW | SLFNTLFMNP | CCLGFIAFAY | SVKSRDRKMV | GDVTGAQAYA | 
    133:
    STAKCLNIWA | LILGILMTIL | LIVIPVLIFQ | AYG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Interferon-induced transmembrane protein 3
    Cat.:
    E10026h
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    96T
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    ELISA Kit for Human Interferon-induced transmembrane protein 3
    Cat.:
    E10026r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Interferon-induced transmembrane protein 3
    Cat.:
    E10026m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Interferon-induced transmembrane protein 3
    Cat.:
    U10026r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Interferon-induced transmembrane protein 3
    Cat.:
    U10026h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Interferon-induced transmembrane protein 3
    Cat.:
    U10026m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Interferon-induced transmembrane protein 3
    Polyclonal Antibody for Human Interferon-induced transmembrane protein 3
    Polyclonal Antibody for Human Interferon-induced transmembrane protein 3
    Cat.:
    P10026Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Interferon-induced transmembrane protein 3
    Monoclonal Antibody for Human Interferon-induced transmembrane protein 3
    Monoclonal Antibody for Human Interferon-induced transmembrane protein 3
    Protein for Human Interferon-induced transmembrane protein 3
    Protein for Human Interferon-induced transmembrane protein 3
    Protein for Human Interferon-induced transmembrane protein 3

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular analysis of a human interferon-inducible gene family."
      Lewin A.R. , Reid L.E. , McMahon M. , Stark G.R. , Kerr I.M.
      Eur. J. Biochem.199:417-423(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];INVOLVEMENT IN SUSCEPTIBILITY TO SEVERE INFLUENZA INFECTION
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-3
      tissue: Brain.
      tissue: Cervix.
      tissue: Vascular endothelial cell.
    8. 8.
      "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."
      Brass A.L. , Huang I.C. , Benita Y. , John S.P. , Krishnan M.N. , Feeley E.M. , Ryan B.J. , Weyer J.L. , van der Weyden L. , Fikrig E. , Adams D.J. , Xavier R.J. , Farzan M. , Elledge S.J.
      Cell139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VIRAL RESISTANCE
    9. 9.
      "Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections."
      Jiang D. , Weidner J.M. , Qing M. , Pan X.B. , Guo H. , Xu C. , Zhang X. , Birk A. , Chang J. , Shi P.Y. , Block T.M. , Guo J.T.
      J. Virol.84:8332-8341(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."
      Weidner J.M. , Jiang D. , Pan X.B. , Chang J. , Block T.M. , Guo J.T.
      J. Virol.84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    11. 11.
      "Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression."
      El-Tanani M.K. , Jin D. , Campbell F.C. , Johnston P.G.
      Oncogene29:752-762(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPP1
    12. 12.
      "Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3."
      Yount J.S. , Moltedo B. , Yang Y.Y. , Charron G. , Moran T.M. , Lopez C.B. , Hang H.C.
      Nat. Chem. Biol.6:610-614(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-71; CYS-72 AND CYS-105
    13. 13.
      "The small interferon-induced transmembrane genes and proteins."
      Siegrist F. , Ebeling M. , Certa U.
      J. Interferon Cytokine Res.31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    14. 14.
      "The IFITM proteins inhibit HIV-1 infection."
      Lu J. , Pan Q. , Rong L. , He W. , Liu S.L. , Liang C.
      J. Virol.85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    16. 16.
      "IFITM3 inhibits influenza A virus infection by preventing cytosolic entry."
      Feeley E.M. , Sims J.S. , John S.P. , Chin C.R. , Pertel T. , Chen L.M. , Gaiha G.D. , Ryan B.J. , Donis R.O. , Elledge S.J. , Brass A.L.
      PLoS Pathog.7:E1002337-E1002337(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    17. 17.
      "Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus."
      Huang I.C. , Bailey C.C. , Weyer J.L. , Radoshitzky S.R. , Becker M.M. , Chiang J.J. , Brass A.L. , Ahmed A.A. , Chi X. , Dong L. , Longobardi L.E. , Boltz D. , Kuhn J.H. , Elledge S.J. , Bavari S. , Denison M.R. , Choe H. , Farzan M.
      PLoS Pathog.7:E1001258-E1001258(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 18.
      "S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus."
      Yount J.S. , Karssemeijer R.A. , Hang H.C.
      J. Biol. Chem.287:19631-19641(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-24; LYS-83; LYS-88 AND LYS-104;PALMITOYLATION;TOPOLOGY;ABSENCE OF GLYCOSYLATION;SUBCELLULAR LOCATION
    19. 19.
      "IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."
      Chan Y.K. , Huang I.C. , Farzan M.
      PLoS ONE7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    20. 20.
      "The dispanins: a novel gene family of ancient origin that contains 14 human members."
      Sallman Almen M. , Bringeland N. , Fredriksson R. , Schioth H.B.
      PLoS ONE7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE FAMILY
    21. 21.
      "The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry."
      Amini-Bavil-Olyaee S. , Choi Y.J. , Lee J.H. , Shi M. , Huang I.C. , Farzan M. , Jung J.U.
      Cell Host Microbe13:452-464(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH VAPA
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