IFITM3 ELISA Kit for Human(Homo sapiens) | EIAab.comIFITM3 ELISA Kit for Human(Homo sapiens)

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IFITM3 (Gene name),

Interferon-induced transmembrane protein 3 (Protein name ), IFM3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IFITM3;

Protein name:

Interferon-induced transmembrane protein 3;

Alternative:

Interferon-inducible protein 1-8U;Interferon-inducible protein 1-8U(DSPA2b);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SPP1; the interaction reduces OPN expression.

Function:

IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

133

Sequence:

50:

100:

133:

STAKCLNIWA | LILGILMTIL | LIVIPVLIFQ | AYG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF04505

STRING:

9606.ENSP00000382707

KEGG:

hsa:10410

UniGene:

Hs.374650

String:

Q01628

MIM:

605579

Uniprot:

Q01628

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ELISA Kit for Human Interferon-induced transmembrane protein 3

Cat.:

E10026h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Interferon-induced transmembrane protein 3

Cat.:

E10026r

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MSDS:

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Packing:

96T

ELISA Kit for Human Interferon-induced transmembrane protein 3

Cat.:

E10026m

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Packing:

96T

CLIA Kit for Human Interferon-induced transmembrane protein 3

Cat.:

U10026r

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MSDS:

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Packing:

96T

CLIA Kit for Human Interferon-induced transmembrane protein 3

Cat.:

U10026h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Interferon-induced transmembrane protein 3

Cat.:

U10026m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Interferon-induced transmembrane protein 3

Cat.:

P10026Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Interferon-induced transmembrane protein 3

Protein for Human Interferon-induced transmembrane protein 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular analysis of a human interferon-inducible gene family."
Lewin A.R. , Reid L.E. , McMahon M. , Stark G.R. , Kerr I.M.
Eur. J. Biochem.199:417-423(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"IFITM3 restricts the morbidity and mortality associated with influenza."
Everitt A.R. , Clare S. , Pertel T. , John S.P. , Wash R.S. , Smith S.E. , Chin C.R. , Feeley E.M. , Sims J.S. , Adams D.J. , Wise H.M. , Kane L. , Goulding D. , Digard P. , Anttila V. , Baillie J.K. , Walsh T.S. , Hume D.A. , more...
Nature484:519-523(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];INVOLVEMENT IN SUSCEPTIBILITY TO SEVERE INFLUENZA INFECTION
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-3
tissue: Brain.
tissue: Cervix.
tissue: Vascular endothelial cell.
8.

"The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."
Brass A.L. , Huang I.C. , Benita Y. , John S.P. , Krishnan M.N. , Feeley E.M. , Ryan B.J. , Weyer J.L. , van der Weyden L. , Fikrig E. , Adams D.J. , Xavier R.J. , Farzan M. , Elledge S.J.
Cell139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VIRAL RESISTANCE
9.

"Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections."
Jiang D. , Weidner J.M. , Qing M. , Pan X.B. , Guo H. , Xu C. , Zhang X. , Birk A. , Chang J. , Shi P.Y. , Block T.M. , Guo J.T.
J. Virol.84:8332-8341(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."
Weidner J.M. , Jiang D. , Pan X.B. , Chang J. , Block T.M. , Guo J.T.
J. Virol.84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression."
El-Tanani M.K. , Jin D. , Campbell F.C. , Johnston P.G.
Oncogene29:752-762(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPP1
12.

"Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3."
Yount J.S. , Moltedo B. , Yang Y.Y. , Charron G. , Moran T.M. , Lopez C.B. , Hang H.C.
Nat. Chem. Biol.6:610-614(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-71; CYS-72 AND CYS-105
13.

"The small interferon-induced transmembrane genes and proteins."
Siegrist F. , Ebeling M. , Certa U.
J. Interferon Cytokine Res.31:183-197(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
14.

"The IFITM proteins inhibit HIV-1 infection."
Lu J. , Pan Q. , Rong L. , He W. , Liu S.L. , Liang C.
J. Virol.85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

Lu J. , Pan Q. , Rong L. , He W. , Liu S.L. , Liang C.
J. Virol.85:4043-4043(2011)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
16.

"IFITM3 inhibits influenza A virus infection by preventing cytosolic entry."
Feeley E.M. , Sims J.S. , John S.P. , Chin C.R. , Pertel T. , Chen L.M. , Gaiha G.D. , Ryan B.J. , Donis R.O. , Elledge S.J. , Brass A.L.
PLoS Pathog.7:E1002337-E1002337(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
17.

"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus."
Huang I.C. , Bailey C.C. , Weyer J.L. , Radoshitzky S.R. , Becker M.M. , Chiang J.J. , Brass A.L. , Ahmed A.A. , Chi X. , Dong L. , Longobardi L.E. , Boltz D. , Kuhn J.H. , Elledge S.J. , Bavari S. , Denison M.R. , Choe H. , Farzan M.
PLoS Pathog.7:E1001258-E1001258(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus."
Yount J.S. , Karssemeijer R.A. , Hang H.C.
J. Biol. Chem.287:19631-19641(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-24; LYS-83; LYS-88 AND LYS-104;PALMITOYLATION;TOPOLOGY;ABSENCE OF GLYCOSYLATION;SUBCELLULAR LOCATION
19.

"IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."
Chan Y.K. , Huang I.C. , Farzan M.
PLoS ONE7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"The dispanins: a novel gene family of ancient origin that contains 14 human members."
Sallman Almen M. , Bringeland N. , Fredriksson R. , Schioth H.B.
PLoS ONE7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE FAMILY
21.

"The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry."
Amini-Bavil-Olyaee S. , Choi Y.J. , Lee J.H. , Shi M. , Huang I.C. , Farzan M. , Jung J.U.
Cell Host Microbe13:452-464(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH VAPA

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