Protein name:
Intraflagellar transport protein 57 homolog ;
Alternative:
HIP1-interacting protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with HIP1. In normal conditions, it poorly interacts with HIP1, HIP1 beeing strongly associated with HTT. However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57, leading to apoptosis. Interacts with BFAR (By similarity). Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20. Interacts with IFT20 and IFT88. Interacts with BLOC1S2 and RYBP. Interacts with HOMER1, possibly leading to prevent pro-apoptotic effects of IFT57.
Function:
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Subcellular Location:
Cytoplasm
cytoskeleton
cilium basal body
Golgi apparatus
Concentrates within the inner segment of cilia.
Protein Attributes:
50:
MAAAAAVIPP | SGLDDGVSRA | RGEGAGEAVV | ERGPGAAYHM | FVVMEDLVEK |
100:
LKLLRYEEEL | LRKSNLKPPS | RHYFALPTNP | GEQFYMFCTL | AAWLINKTGR |
150:
AFEQPQEYDD | PNATISNILS | ELRSFGRTAD | FPPSKLKSGY | GEQVCYVLDC |
200:
LAEEALKYIG | FTWKRPSYPV | EELEEETVPE | DDAELTLSKV | DEEFVEEETD |
250:
NEENFIDLNV | LKAQTYRLDT | NESAKQEDIL | ESTTDAAEWS | LEVERVLPQL |
300:
KVTIRTDNKD | WRIHVDQMHQ | HKSGIESALK | ETKGFLDKLH | NEISRTLEKI |
350:
GSREKYINNQ | LEHLVQEYRG | AQAQLSEARE | RYQQGNGGVT | ERTRLLSEVT |
400:
EELEKVKQEM | EEKGSSMTDG | TPLVKIKQSL | TKLKQETVQM | DIRIGVVEHT |
429:
LLQSKLKEKC | NMTRDMHAAV | TPESAIGFY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
ELISA Kit for Mouse Intraflagellar transport protein 57 homolog
ELISA Kit for Mouse Intraflagellar transport protein 57 homolog
ELISA Kit for Mouse Intraflagellar transport protein 57 homolog
CLIA Kit for Mouse Intraflagellar transport protein 57 homolog
CLIA Kit for Mouse Intraflagellar transport protein 57 homolog
CLIA Kit for Mouse Intraflagellar transport protein 57 homolog
Polyclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
Polyclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
Polyclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
Monoclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
Monoclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
Monoclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
Protein for Mouse Intraflagellar transport protein 57 homolog
Protein for Mouse Intraflagellar transport protein 57 homolog
Protein for Mouse Intraflagellar transport protein 57 homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Nat. Cell Biol.4:95-105(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
C57BL/6J .
3.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-357 (ISOFORM 2)
strain :
C57BL/6J .
tissue :
Cerebellum .
tissue :
Head .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IFT88
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IFT20
7.
"Hippi is essential for node cilia assembly and Sonic hedgehog signaling."
Houde C.
,
Dickinson R.J.
,
Houtzager V.M.
,
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,
Metzler M.
,
Simpson E.M.
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Roy S.
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Hayden M.R.
,
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,
Nicholson D.W.
Dev. Biol.300:523-533(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RYBP
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INTERACTION WITH HOMER1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BLOC1S2
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE IFT COMPLEX B;INTERACTION WITH IFT88;SUBCELLULAR LOCATION