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Index > Protein center > Ift57(Gene name) > Mouse
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  • Ift57 (Gene name),
  • Intraflagellar transport protein 57 homolog (Protein name ),  IFT57_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ift57(Hippi);
    Protein name:
    Intraflagellar transport protein 57 homolog;
    Alternative:
    HIP1-interacting protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with HIP1. In normal conditions, it poorly interacts with HIP1, HIP1 beeing strongly associated with HTT. However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57, leading to apoptosis. Interacts with BFAR (By similarity). Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20. Interacts with IFT20 and IFT88. Interacts with BLOC1S2 and RYBP. Interacts with HOMER1, possibly leading to prevent pro-apoptotic effects of IFT57.
    Function:
    Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
    Subcellular Location:
    Cytoplasm cytoskeleton cilium basal body Golgi apparatus Concentrates within the inner segment of cilia.
    Protein Attributes:
    Sequence length:
    429
    Sequence:
    50:
    MAAAAAVIPP | SGLDDGVSRA | RGEGAGEAVV | ERGPGAAYHM | FVVMEDLVEK | 
    100:
    LKLLRYEEEL | LRKSNLKPPS | RHYFALPTNP | GEQFYMFCTL | AAWLINKTGR | 
    150:
    AFEQPQEYDD | PNATISNILS | ELRSFGRTAD | FPPSKLKSGY | GEQVCYVLDC | 
    200:
    LAEEALKYIG | FTWKRPSYPV | EELEEETVPE | DDAELTLSKV | DEEFVEEETD | 
    250:
    NEENFIDLNV | LKAQTYRLDT | NESAKQEDIL | ESTTDAAEWS | LEVERVLPQL | 
    300:
    KVTIRTDNKD | WRIHVDQMHQ | HKSGIESALK | ETKGFLDKLH | NEISRTLEKI | 
    350:
    GSREKYINNQ | LEHLVQEYRG | AQAQLSEARE | RYQQGNGGVT | ERTRLLSEVT | 
    400:
    EELEKVKQEM | EEKGSSMTDG | TPLVKIKQSL | TKLKQETVQM | DIRIGVVEHT | 
    429:
    LLQSKLKEKC | NMTRDMHAAV | TPESAIGFY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Intraflagellar transport protein 57 homolog
    ELISA Kit for Mouse Intraflagellar transport protein 57 homolog
    ELISA Kit for Mouse Intraflagellar transport protein 57 homolog
    CLIA Kit for Mouse Intraflagellar transport protein 57 homolog
    CLIA Kit for Mouse Intraflagellar transport protein 57 homolog
    CLIA Kit for Mouse Intraflagellar transport protein 57 homolog
    Polyclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
    Polyclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
    Polyclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
    Monoclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
    Monoclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
    Monoclonal Antibody for Mouse Intraflagellar transport protein 57 homolog
    Protein for Mouse Intraflagellar transport protein 57 homolog
    Protein for Mouse Intraflagellar transport protein 57 homolog
    Protein for Mouse Intraflagellar transport protein 57 homolog

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    Precision
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    Linearity
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    References
    1. 1.
      "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi."
      Gervais F.G. , Singaraja R. , Xanthoudakis S. , Gutekunst C.-A. , Leavitt B.R. , Metzler M. , Hackam A.S. , Tam J. , Vaillancourt J.P. , Houtzager V. , Rasper D.M. , Roy S. , Hayden M.R. , Nicholson D.W.
      Nat. Cell Biol.4:95-105(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "Mouse intraflagellar transport protein IFT57."
      Pazour G.J. , Walker B.L. , Witman G.B. , Rosenbaum J.L. , Cole D.G.
      Submitted (2005-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: C57BL/6J.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-357 (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Head.
    4. 4.
      "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella."
      Pazour G.J. , Dickert B.L. , Vucica Y. , Seeley E.S. , Rosenbaum J.L. , Witman G.B. , Cole D.G.
      J. Cell Biol.151:709-718(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IFT88
    5. 5.
      "The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance."
      Pazour G.J. , Baker S.A. , Deane J.A. , Cole D.G. , Dickert B.L. , Rosenbaum J.L. , Witman G.B. , Besharse J.C.
      J. Cell Biol.157:103-113(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia."
      Baker S.A. , Freeman K. , Luby-Phelps K. , Pazour G.J. , Besharse J.C.
      J. Biol. Chem.278:34211-34218(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IFT20
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
    8. 8.
      "Rybp interacts with Hippi and enhances Hippi-mediated apoptosis."
      Stanton S.E. , Blanck J.K. , Locker J. , Schreiber-Agus N.
      Apoptosis12:2197-2206(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RYBP
    9. 9.
      "Homer1c interacts with Hippi and protects striatal neurons from apoptosis."
      Sakamoto K. , Yoshida S. , Ikegami K. , Minakami R. , Kato A. , Udo H. , Sugiyama H.
      Biochem. Biophys. Res. Commun.352:1-5(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH HOMER1
    10. 10.
      "BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis."
      Gdynia G. , Lehmann-Koch J. , Sieber S. , Tagscherer K.E. , Fassl A. , Zentgraf H. , Matsuzawa S. , Reed J.C. , Roth W.
      Apoptosis13:437-447(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BLOC1S2
    11. 11.
      "Spatial distribution of intraflagellar transport proteins in vertebrate photoreceptors."
      Luby-Phelps K. , Fogerty J. , Baker S.A. , Pazour G.J. , Besharse J.C.
      Vision Res.48:413-423(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE IFT COMPLEX B;INTERACTION WITH IFT88;SUBCELLULAR LOCATION
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