Protein name:
Immunoglobulin superfamily member 2 (IgSF2) ;
Alternative:
Glu-Trp-Ile EWI motif-containing protein 101 (EWI-101) ;
CD:
CD101 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MACILCVASL | FLSLTKFSIG | QREVKIQEGP | LYRAEGYPVS | IRCTVSGHQG |
100:
PSTQDFRWSI | YLPSAPTKEV | QIISTKDAGF | SYAVYAQRVQ | SKEIYIERLQ |
150:
GDSVLLHISK | LQMKDAGEYE | CHTPNTDGKY | FGSYSAKTNL | TVVPDTLSAT |
200:
MPSQTLSKKE | GEPLELTCET | TKATVQHTHL | SLTWYLMQEG | GGSQATEIVS |
250:
LSKDFVLTPG | SSYADRFVAG | DVRLDKLGAT | SFRLSVGKLQ | PSDQGQVFCE |
300:
ATEWIQDPDE | TWTLITRKQT | DQTALRIQPA | ARDFTVSITA | SSSPDEGKPL |
350:
ELVCLAVGRD | GNPQLQGVWF | LNGKEIAQTD | AGGVLDLKRD | YRDRASQGQL |
400:
QVSKLSAQTF | SLKIFSVGPE | DVGTYSCEVA | EVARTQMGSW | QVLQRKQSPG |
450:
YRVQLREPAA | RSVTVSAEQR | TVWEGETLTL | LCKAAGDVSA | LSVSWWLTPQ |
500:
DQSTPVFVAG | MGQDGTVQLG | VSSPGPAHRG | NRRLEKVDWA | TFRLEIASAM |
550:
VTDSGTYECR | VSERLQNQAK | GLQSTQKISV | TVKSLKSSLR | VNLMSRQPQV |
600:
MLAHTFHLSC | VVRANYSDLK | LPFSVTWQFQ | PAGSGAFHRL | IRIAHNGTVE |
650:
WGDVLSQIHR | KTKVSQSFFR | SQLQIYDAAM | EETGVYRCTV | EVYDRDSICT |
700:
SGPARVSATS | NLLMITVTFP | ESKLSVNSSS | QVQELSISSS | TQIECAILSR |
750:
SAGNLPLSII | WYFSSVSANA | SYLKILEMDQ | SSVVKYGDEF | QTPRSKQKFY |
800:
SEKVSQDLFL | LNILSVEDSD | QGHYHCAVEE | WLLSTNDTWQ | KLERKTSGLT |
850:
ELKLRPTGSQ | VHVSKVNWTG | NATEYGEAGF | SCSLDGSGST | ASLYSVTWYR |
900:
GRGTATATAA | AVANATATIT | APAGSQMLVH | LQYDGLLQYG | REGSRRLQHC |
950:
YRSSPTDFVL | KLHRVEMEDA | GIYWCRVTEW | QQHGHPGKWI | NQASGESQRM |
1000:
VLRVLRSEPT | VSSLICSSGP | LLHFLIVCPF | VMLLLLATSF | LCLYRKARKL |
1033:
SQLSLSAKKE | KALWVGMRKT | SLQKEAGEES | GHY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse IgSF2
ELISA Kit for Mouse IgSF2
Polyclonal Antibody for Mouse IgSF2
Polyclonal Antibody for Mouse IgSF2
Monoclonal Antibody for Mouse IgSF2
Monoclonal Antibody for Mouse IgSF2
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
"Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice."
Penha-Goncalves C.
,
Moule C.
,
Smink L.J.
,
Howson J.
,
Gregory S.
,
Rogers J.
,
Lyons P.A.
,
Suttie J.J.
,
Lord C.J.
,
Peterson L.B.
,
Todd J.A.
,
Wicker L.S.
Diabetes52:1551-1556(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
NOD.B6 .
strain :
NOD/MrkTac .