Protein name:
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha;IKK-A;IKK-alpha;IkBKA;IkappaB kinase) ;
Alternative:
I-kappa-B kinase 1 (IKK1) ;Conserved helix-loop-helix ubiquitous kinase ;Nuclear factor NF-kappa-B inhibitor kinase alpha (NFKBIKA) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Directly interacts with IKK-gamma/NEMO and TRPC4AP. May interact with TRAF2. Interacts with NALP2. May interact with MAVS/IPS1. Interacts with ARRB1 (By similarity). Interacts with NLRC5; prevents CHUK phosphorylation and kinase activity (By similarity). Interacts with ARRB2.
Function:
Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
Subcellular Location:
Cytoplasm
Nucleus
Shuttles between the cytoplasm and the nucleus.
Protein Attributes:
50:
MERPPGLRPG | AGGPWEMRER | LGTGGFGNVS | LYQHRELDLK | IAIKSCRLEL |
100:
SSKNRERWCH | EIQIMKKLDH | ANVVKACDVP | EELNFLINDV | PLLAMEYCSG |
150:
GDLRKLLNKP | ENCCGLKESQ | ILSLLSDIGS | GIRYLHENKI | IHRDLKPENI |
200:
VLQDVGGKTI | HKIIDLGYAK | DVDQGSLCTS | FVGTLQYLAP | ELFENKPYTA |
250:
TVDYWSFGTM | VFECIAGYRP | FLHHLQPFTW | HEKIKKKDPK | CIFACEEMTG |
300:
EVRFSSHLPQ | PNSLCSLIVE | PMESWLQLML | NWDPQQRGGP | IDLTLKQPRC |
350:
FALMDHILNL | KIVHILNMTS | AKIISFLLPC | DESLHSLQSR | IERETGINTG |
400:
SQELLSETGI | SLDPRKPASQ | CVLDGVRGCD | SYMVYLFDKS | KTVYEGPFAS |
450:
RSLSDCVNYI | VQDSKIQLPI | IQLRKVWAEA | VHYVSGLKED | YSRLFQGQRA |
500:
AMLSLLRYNA | NLTKMKNTLI | SASQQLKAKL | EFFRKSIQLD | LERYSEQMTY |
550:
GISSEKMLKA | WKEMEEKAIH | YSEVGVIGYL | EDQIMSLHTE | IMELQKSPYG |
600:
RRQGDLMESL | EQRAIDLYKQ | LKHRPPDHLY | SDSTEMVKII | VHTVQSQDRV |
650:
LKELFGHLSK | LLGCKQKIID | LLPKVEVALS | NIKEADNTVM | FMQGKRQKEI |
700:
WHLLKIACTQ | SSARSLVGSS | LEGTVTPPVS | AWLPPTLADR | EHPLTCVVTP |
745:
QDGETLAQMI | EENLNCLGHL | STIIREANED | QSSSLMSLDW | SWLAE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Human
Mouse
Bovine
ELISA Kit for Mouse I-kappa-B kinase alpha
ELISA Kit for Mouse I-kappa-B kinase alpha
ELISA Kit for Mouse I-kappa-B kinase alpha
ELISA Kit for Mouse I-kappa-B kinase alpha
CLIA Kit for Mouse I-kappa-B kinase alpha
CLIA Kit for Mouse I-kappa-B kinase alpha
CLIA Kit for Mouse I-kappa-B kinase alpha
CLIA Kit for Mouse I-kappa-B kinase alpha
Polyclonal Antibody for Mouse I-kappa-B kinase alpha
Polyclonal Antibody for Mouse I-kappa-B kinase alpha
Polyclonal Antibody for Mouse I-kappa-B kinase alpha
Polyclonal Antibody for Mouse I-kappa-B kinase alpha
Monoclonal Antibody for Mouse I-kappa-B kinase alpha
Monoclonal Antibody for Mouse I-kappa-B kinase alpha
Monoclonal Antibody for Mouse I-kappa-B kinase alpha
Monoclonal Antibody for Mouse I-kappa-B kinase alpha
Protein for Mouse I-kappa-B kinase alpha
Protein for Mouse I-kappa-B kinase alpha
Protein for Mouse I-kappa-B kinase alpha
Protein for Mouse I-kappa-B kinase alpha
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
BALB/c .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
BALB/c .
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
strain :
C57BL/6J .
tissue :
Colon .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Eye .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY MAP3K14/NIK
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IKKA-IKKB BINDING
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IKK PHOSPHORYLATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ARRB2
13.
"Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression."
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Nat. Cell Biol.12:758-767(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TERF2IP