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Index > Protein center > Chuk(Gene name) > Mouse
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  • Chuk (Gene name),
  • Inhibitor of nuclear factor kappa-B kinase subunit alpha (Protein name ),  IKKA_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Chuk(Ikka);
    Protein name:
    Inhibitor of nuclear factor kappa-B kinase subunit alpha(I-kappa-B kinase alpha;IKK-A;IKK-alpha;IkBKA;IkappaB kinase);
    Alternative:
    I-kappa-B kinase 1(IKK1);Conserved helix-loop-helix ubiquitous kinase;Nuclear factor NF-kappa-B inhibitor kinase alpha(NFKBIKA);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Directly interacts with IKK-gamma/NEMO and TRPC4AP. May interact with TRAF2. Interacts with NALP2. May interact with MAVS/IPS1. Interacts with ARRB1 (By similarity). Interacts with NLRC5; prevents CHUK phosphorylation and kinase activity (By similarity). Interacts with ARRB2.
    Function:
    Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
    Subcellular Location:
    Cytoplasm Nucleus Shuttles between the cytoplasm and the nucleus.
    Protein Attributes:
    Sequence length:
    745
    Sequence:
    50:
    MERPPGLRPG | AGGPWEMRER | LGTGGFGNVS | LYQHRELDLK | IAIKSCRLEL | 
    100:
    SSKNRERWCH | EIQIMKKLDH | ANVVKACDVP | EELNFLINDV | PLLAMEYCSG | 
    150:
    GDLRKLLNKP | ENCCGLKESQ | ILSLLSDIGS | GIRYLHENKI | IHRDLKPENI | 
    200:
    VLQDVGGKTI | HKIIDLGYAK | DVDQGSLCTS | FVGTLQYLAP | ELFENKPYTA | 
    250:
    TVDYWSFGTM | VFECIAGYRP | FLHHLQPFTW | HEKIKKKDPK | CIFACEEMTG | 
    300:
    EVRFSSHLPQ | PNSLCSLIVE | PMESWLQLML | NWDPQQRGGP | IDLTLKQPRC | 
    350:
    FALMDHILNL | KIVHILNMTS | AKIISFLLPC | DESLHSLQSR | IERETGINTG | 
    400:
    SQELLSETGI | SLDPRKPASQ | CVLDGVRGCD | SYMVYLFDKS | KTVYEGPFAS | 
    450:
    RSLSDCVNYI | VQDSKIQLPI | IQLRKVWAEA | VHYVSGLKED | YSRLFQGQRA | 
    500:
    AMLSLLRYNA | NLTKMKNTLI | SASQQLKAKL | EFFRKSIQLD | LERYSEQMTY | 
    550:
    GISSEKMLKA | WKEMEEKAIH | YSEVGVIGYL | EDQIMSLHTE | IMELQKSPYG | 
    600:
    RRQGDLMESL | EQRAIDLYKQ | LKHRPPDHLY | SDSTEMVKII | VHTVQSQDRV | 
    650:
    LKELFGHLSK | LLGCKQKIID | LLPKVEVALS | NIKEADNTVM | FMQGKRQKEI | 
    700:
    WHLLKIACTQ | SSARSLVGSS | LEGTVTPPVS | AWLPPTLADR | EHPLTCVVTP | 
    745:
    QDGETLAQMI | EENLNCLGHL | STIIREANED | QSSSLMSLDW | SWLAE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse I-kappa-B kinase alpha
    ELISA Kit for Mouse I-kappa-B kinase alpha
    ELISA Kit for Mouse I-kappa-B kinase alpha
    ELISA Kit for Mouse I-kappa-B kinase alpha
    CLIA Kit for Mouse I-kappa-B kinase alpha
    CLIA Kit for Mouse I-kappa-B kinase alpha
    CLIA Kit for Mouse I-kappa-B kinase alpha
    CLIA Kit for Mouse I-kappa-B kinase alpha
    Polyclonal Antibody for Mouse I-kappa-B kinase alpha
    Polyclonal Antibody for Mouse I-kappa-B kinase alpha
    Polyclonal Antibody for Mouse I-kappa-B kinase alpha
    Polyclonal Antibody for Mouse I-kappa-B kinase alpha
    Monoclonal Antibody for Mouse I-kappa-B kinase alpha
    Monoclonal Antibody for Mouse I-kappa-B kinase alpha
    Monoclonal Antibody for Mouse I-kappa-B kinase alpha
    Monoclonal Antibody for Mouse I-kappa-B kinase alpha
    Protein for Mouse I-kappa-B kinase alpha
    Protein for Mouse I-kappa-B kinase alpha
    Protein for Mouse I-kappa-B kinase alpha
    Protein for Mouse I-kappa-B kinase alpha

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19."
      Mock B.A. , Connelly M.A. , McBride O.W. , Kozak C.A. , Marcu K.B.
      Genomics27:348-351(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: BALB/c.
    2. 2.
      "CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain."
      Connelly M.A. , Marcu K.B.
      Cell. Mol. Biol. Res.41:537-549(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: BALB/c.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: C57BL/6J.
      tissue: Colon.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Eye.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    6. 6.
      "Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements."
      McKenzie F.R. , Connelly M.A. , Balzarano D. , Mueller J.R. , Geleziunas R. , Marcu K.B.
      Mol. Cell. Biol.20:2635-2649(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
    7. 7.
      "Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1."
      Nakano H. , Shindo M. , Sakon S. , Nishinaka S. , Mihara M. , Yagita H. , Okumura K.
      Proc. Natl. Acad. Sci. U.S.A.95:3537-3542(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY MAP3K14/NIK
    8. 8.
      "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation."
      Delhase M. , Hayakawa M. , Chen Y. , Karin M.
      Science284:309-313(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IKKA-IKKB BINDING
    9. 9.
      "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase."
      Nemoto S. , DiDonato J.A. , Lin A.
      Mol. Cell. Biol.18:7336-7343(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IKK PHOSPHORYLATION
    10. 10.
      "The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection."
      Jobin C. , Sartor R.B.
      Am. J. Physiol.278:C451-C462(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    11. 11.
      "Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression."
      Yamamoto Y. , Verma U.N. , Prajapati S. , Kwak Y.T. , Gaynor R.B.
      Nature423:655-659(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    12. 12.
      "Beta2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappaB activation through beta-arrestin 2."
      Kizaki T. , Izawa T. , Sakurai T. , Haga S. , Taniguchi N. , Tajiri H. , Watanabe K. , Day N.K. , Toba K. , Ohno H.
      Immunology124:348-356(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2
    13. 13.
      "Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression."
      Teo H. , Ghosh S. , Luesch H. , Ghosh A. , Wong E.T. , Malik N. , Orth A. , de Jesus P. , Perry A.S. , Oliver J.D. , Tran N.L. , Speiser L.J. , Wong M. , Saez E. , Schultz P. , Chanda S.K. , Verma I.M. , Tergaonkar V.
      Nat. Cell Biol.12:758-767(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TERF2IP
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