IKZF1 ELISA Kit for Human(Homo sapiens) | EIAab.comIKZF1 ELISA Kit for Human(Homo sapiens)

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IKZF1 (Gene name),

DNA-binding protein Ikaros (Protein name ), IKZF1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

IKZF1(IK1;IKAROS;LYF1;ZNFN1A1);

Protein name:

DNA-binding protein Ikaros;

Alternative:

Lymphoid transcription factor LyF-1;Ikaros family zinc finger protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5 (By similarity). Component of the chromatin-remodeling NuRD repressor complex which includes at least HDAC1, HDAC2, RBBP4, RBBP7, IKZF1, MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4. Interacts directly with the CHD4 component of the NuRD complex. Component of the BAF (SWI/SNF) gene activator complex which includes ACTB, ARID1A, ARID1B, IKZF1, ARID1A, ARID1B, SMARCA2, SMARCA4 and at least one BAF subunit. Interacts directly with the SMARCA4 component of the BAF complex (By similarity). Interacts with SUMO1; the interaction sumoylates IKAROS, promoted by PIAS2 and PIAS3. Interacts with PIAS2 (isoform alpha); the interaction promotes sumoylation and reduces transcription repression. Interacts, to a lesser extent, with PIAS3. Interacts with PPP1CC; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with IKZF3.

Function:

Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs).

Subcellular Location:

Isoform Ik6 Cytoplasm

Protein Attributes:

Sequence length:

519

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

519:

DRYEFSSHIT | RGEHRFHMS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

603023

String:

Q13422

KEGG:

hsa:10320

STRING:

9606.ENSP00000331614

UniGene:

Hs.435949

Pfam:

PF00096

SMR:

Q13422

Uniprot:

Q13422

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ELISA Kit for Human DNA-binding protein Ikaros

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ELISA Kit for Human DNA-binding protein Ikaros

Cat.:

E14258m

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Packing:

96T

ELISA Kit for Human DNA-binding protein Ikaros

Cat.:

E14258h

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96T

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CLIA Kit for Human DNA-binding protein Ikaros

Cat.:

U14258h

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96T

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CLIA Kit for Human DNA-binding protein Ikaros

Cat.:

U14258m

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Packing:

96T

CLIA Kit for Human DNA-binding protein Ikaros

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Polyclonal Antibody for Human DNA-binding protein Ikaros

Monoclonal Antibody for Human DNA-binding protein Ikaros

Protein for Human DNA-binding protein Ikaros

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1."
Nietfeld W. , Meyerhans A.
Immunol. Lett.49:139-141(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
tissue: Bone marrow.
2.

"The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse."
Molnar A. , Wu P. , Largespada D.A. , Vortkamp A. , Scherer S. , Copeland N.G. , Jenkins N.A. , Bruns G. , Georgopoulos K.
J. Immunol.156:585-592(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Molecular misreading is involved in generation of Ikaros diversity."
Sanchez-Tapia E.M. , Rodriguez R.E. , Gonzalez-Sarmiento R.
Submitted (2003-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IKX)
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IK2)
tissue: Thymus.
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IK7)
6.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"Human chromosome 7: DNA sequence and biology."
Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IK7)
tissue: Lymph.
10.

"Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes."
Kim J. , Sif S. , Jones B. , Jackson A. , Koipally J. , Heller E. , Winandy S. , Viel A. , Sawyer A. , Ikeda T. , Kingston R. , Georgopoulos K.
Immunity10:345-355(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NURD COMPLEX;IDENTIFICATION IN THE BAF COMPLEX;INTERACTION WITH SMARCA4 AND CHD4;FUNCTION
11.

"The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma."
Hosokawa Y. , Maeda Y. , Ichinohasama R. , Miura I. , Taniwaki M. , Seto M.
Blood95:2719-2721(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN B-CELL NON-HODGKIN LYMPHOMA;CHROMOSOMAL TRANSLOCATION WITH BCL6
12.

"Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities."
Perdomo J. , Holmes M. , Chong B. , Crossley M.
J. Biol. Chem.275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKZF4 AND IKZF5
13.

"Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing."
Kim J.-H. , Ebersole T. , Kouprina N. , Noskov V.N. , Ohzeki J.-I. , Masumoto H. , Mravinac B. , Sullivan B.A. , Pavlicek A. , Dovat S. , Pack S.D. , Kwon Y.-W. , Flanagan P.T. , Loukinov D. , Lobanenkov V. , Larionov V.
Genome Res.19:533-544(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING
14.

"Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia."
Mullighan C.G. , Su X. , Zhang J. , Radtke I. , Phillips L.A. , Miller C.B. , Ma J. , Liu W. , Cheng C. , Schulman B.A. , Harvey R.C. , Chen I.-M. , Clifford R.J. , Carroll W.L. , Reaman G. , Bowman W.P. , Devidas M. , Gerhard D.S. , more...
N. Engl. J. Med.360:470-480(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ACUTE LYMPHOBLASIC LEUKEMIA
15.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-258; SER-261; SER-361 AND SER-364;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros."
Uckun F.M. , Ma H. , Zhang J. , Ozer Z. , Dovat S. , Mao C. , Ishkhanian R. , Goodman P. , Qazi S.
Proc. Natl. Acad. Sci. U.S.A.109:18072-18077(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-361 AND SER-364 BY SYK;SUBCELLULAR LOCATION

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