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Index > Protein center > IKZF1(Gene name) > Human
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  • IKZF1 (Gene name),
  • DNA-binding protein Ikaros (Protein name ),  IKZF1_HUMAN from NCBI database.
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  • Gene name:
    IKZF1(IK1;IKAROS;LYF1;ZNFN1A1);
    Protein name:
    DNA-binding protein Ikaros;
    Alternative:
    Lymphoid transcription factor LyF-1;Ikaros family zinc finger protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5 (By similarity). Component of the chromatin-remodeling NuRD repressor complex which includes at least HDAC1, HDAC2, RBBP4, RBBP7, IKZF1, MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4. Interacts directly with the CHD4 component of the NuRD complex. Component of the BAF (SWI/SNF) gene activator complex which includes ACTB, ARID1A, ARID1B, IKZF1, ARID1A, ARID1B, SMARCA2, SMARCA4 and at least one BAF subunit. Interacts directly with the SMARCA4 component of the BAF complex (By similarity). Interacts with SUMO1; the interaction sumoylates IKAROS, promoted by PIAS2 and PIAS3. Interacts with PIAS2 (isoform alpha); the interaction promotes sumoylation and reduces transcription repression. Interacts, to a lesser extent, with PIAS3. Interacts with PPP1CC; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with IKZF3.
    Function:
    Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs).
    Subcellular Location:
    Isoform Ik6 Cytoplasm
    Protein Attributes:
    Sequence length:
    519
    Sequence:
    50:
    MDADEGQDMS | QVSGKESPPV | SDTPDEGDEP | MPIPEDLSTT | SGGQQSSKSD | 
    100:
    RVVASNVKVE | TQSDEENGRA | CEMNGEECAE | DLRMLDASGE | KMNGSHRDQG | 
    150:
    SSALSGVGGI | RLPNGKLKCD | ICGIICIGPN | VLMVHKRSHT | GERPFQCNQC | 
    200:
    GASFTQKGNL | LRHIKLHSGE | KPFKCHLCNY | ACRRRDALTG | HLRTHSVGKP | 
    250:
    HKCGYCGRSY | KQRSSLEEHK | ERCHNYLESM | GLPGTLYPVI | KEETNHSEMA | 
    300:
    EDLCKIGSER | SLVLDRLASN | VAKRKSSMPQ | KFLGDKGLSD | TPYDSSASYE | 
    350:
    KENEMMKSHV | MDQAINNAIN | YLGAESLRPL | VQTPPGGSEV | VPVISPMYQL | 
    400:
    HKPLAEGTPR | SNHSAQDSAV | ENLLLLSKAK | LVPSEREASP | SNSCQDSTDT | 
    450:
    ESNNEEQRSG | LIYLTNHIAP | HARNGLSLKE | EHRAYDLLRA | ASENSQDALR | 
    500:
    VVSTSGEQMK | VYKCEHCRVL | FLDHVMYTIH | MGCHGFRDPF | ECNMCGYHSQ | 
    519:
    DRYEFSSHIT | RGEHRFHMS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    KEGG:
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human DNA-binding protein Ikaros
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    ELISA Kit for Human DNA-binding protein Ikaros
    Cat.:
    E14258m
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    Packing:
    96T
    ELISA Kit for Human DNA-binding protein Ikaros
    Cat.:
    E14258h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human DNA-binding protein Ikaros
    Cat.:
    U14258h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human DNA-binding protein Ikaros
    Cat.:
    U14258m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA-binding protein Ikaros
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human DNA-binding protein Ikaros
    Polyclonal Antibody for Human DNA-binding protein Ikaros
    Polyclonal Antibody for Human DNA-binding protein Ikaros
    Monoclonal Antibody for Human DNA-binding protein Ikaros
    Monoclonal Antibody for Human DNA-binding protein Ikaros
    Monoclonal Antibody for Human DNA-binding protein Ikaros
    Protein for Human DNA-binding protein Ikaros
    Protein for Human DNA-binding protein Ikaros
    Protein for Human DNA-binding protein Ikaros

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1."
      Nietfeld W. , Meyerhans A.
      Immunol. Lett.49:139-141(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
      tissue: Bone marrow.
    2. 2.
      "The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse."
      Molnar A. , Wu P. , Largespada D.A. , Vortkamp A. , Scherer S. , Copeland N.G. , Jenkins N.A. , Bruns G. , Georgopoulos K.
      J. Immunol.156:585-592(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Molecular misreading is involved in generation of Ikaros diversity."
      Sanchez-Tapia E.M. , Rodriguez R.E. , Gonzalez-Sarmiento R.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IKX)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IK2)
      tissue: Thymus.
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IK7)
    6. 6.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IK7)
      tissue: Lymph.
    9. 10.
      "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes."
      Kim J. , Sif S. , Jones B. , Jackson A. , Koipally J. , Heller E. , Winandy S. , Viel A. , Sawyer A. , Ikeda T. , Kingston R. , Georgopoulos K.
      Immunity10:345-355(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NURD COMPLEX;IDENTIFICATION IN THE BAF COMPLEX;INTERACTION WITH SMARCA4 AND CHD4;FUNCTION
    10. 11.
      "The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma."
      Hosokawa Y. , Maeda Y. , Ichinohasama R. , Miura I. , Taniwaki M. , Seto M.
      Blood95:2719-2721(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN B-CELL NON-HODGKIN LYMPHOMA;CHROMOSOMAL TRANSLOCATION WITH BCL6
    11. 12.
      "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities."
      Perdomo J. , Holmes M. , Chong B. , Crossley M.
      J. Biol. Chem.275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKZF4 AND IKZF5
    12. 13.
      "Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing."
      Kim J.-H. , Ebersole T. , Kouprina N. , Noskov V.N. , Ohzeki J.-I. , Masumoto H. , Mravinac B. , Sullivan B.A. , Pavlicek A. , Dovat S. , Pack S.D. , Kwon Y.-W. , Flanagan P.T. , Loukinov D. , Lobanenkov V. , Larionov V.
      Genome Res.19:533-544(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ACUTE LYMPHOBLASIC LEUKEMIA
    14. 15.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-258; SER-261; SER-361 AND SER-364;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    15. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 17.
      "Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros."
      Uckun F.M. , Ma H. , Zhang J. , Ozer Z. , Dovat S. , Mao C. , Ishkhanian R. , Goodman P. , Qazi S.
      Proc. Natl. Acad. Sci. U.S.A.109:18072-18077(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-361 AND SER-364 BY SYK;SUBCELLULAR LOCATION
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