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Index > Protein center > IL1A(Gene name) > Human
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  • IL1A (Gene name),
  • Interleukin-1 alpha (Protein name ),  IL1A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (4)
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  • Gene name:
    IL1A(IL1F1);
    Protein name:
    Interleukin-1 alpha(IL-1 alpha);
    Alternative:
    Hematopoietin-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
    Subcellular Location:
    Secreted The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
    Protein Attributes:
    Sequence length:
    271
    Sequence:
    50:
    MAKVPDMFED | LKNCYSENEE | DSSSIDHLSL | NQKSFYHVSY | GPLHEGCMDQ | 
    100:
    SVSLSISETS | KTSKLTFKES | MVVVATNGKV | LKKRRLSLSQ | SITDDDLEAI | 
    150:
    ANDSEEEIIK | PRSAPFSFLS | NVKYNFMRII | KYEFILNDAL | NQSIIRANDQ | 
    200:
    YLTAAALHNL | DEAVKFDMGA | YKSSKDDAKI | TVILRISKTQ | LYVTAQDEDQ | 
    250:
    PVLLKEMPEI | PKTITGSETN | LLFFWETHGT | KNYFTSVAHP | NLFIATKQDY | 
    271:
    WVCLAGGPPS | ITDFQILENQ | A
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    UniGene:
    KEGG:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-1 alpha
    Cat.:
    E0071h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-1 alpha
    Cat.:
    E0071m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-1 alpha
    Cat.:
    E0071r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-1 alpha
    Cat.:
    E0071p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-1 alpha
    Cat.:
    E0071b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-1 alpha
    Cat.:
    E0071d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-1 alpha
    Cat.:
    E0071g
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human IL-1 alpha
    MSDS:
    Please sign in first.
    CLIA Kit for Human IL-1 alpha
    Cat.:
    U0071r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-1 alpha
    Cat.:
    U0071h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-1 alpha
    MSDS:
    Please sign in first.
    CLIA Kit for Human IL-1 alpha
    Cat.:
    U0071b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-1 alpha
    Cat.:
    U0071d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-1 alpha
    Cat.:
    U0071m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-1 alpha
    Cat.:
    U0071p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human IL-1 alpha
    Cat.:
    P0071Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-1 alpha
    Cat.:
    P0071Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-1 alpha
    Polyclonal Antibody for Human IL-1 alpha
    Cat.:
    P0071Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-1 alpha
    Polyclonal Antibody for Human IL-1 alpha
    Polyclonal Antibody for Human IL-1 alpha
    Monoclonal Antibody for Human IL-1 alpha
    Monoclonal Antibody for Human IL-1 alpha
    Monoclonal Antibody for Human IL-1 alpha
    Monoclonal Antibody for Human IL-1 alpha
    Monoclonal Antibody for Human IL-1 alpha
    Monoclonal Antibody for Human IL-1 alpha
    Monoclonal Antibody for Human IL-1 alpha
    Protein for Human IL-1 alpha
    Protein for Human IL-1 alpha
    Protein for Human IL-1 alpha
    Protein for Human IL-1 alpha
    Protein for Human IL-1 alpha
    Protein for Human IL-1 alpha
    Protein for Human IL-1 alpha
    Cat.:
    R0071h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

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    References
    1. 1.
      "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs."
      March C.J. , Mosley B. , Larsen A. , Cerretti D.P. , Braedt G. , Price V. , Gillis S. , Henney C.S. , Kronheim S.R. , Grabstein K. , Conlon P.J. , Hopp T.P. , Cosman D.
      Nature315:641-647(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Complete nucleotide sequence of the gene for human interleukin 1 alpha."
      Furutani Y. , Notake M. , Fukui T. , Ohue M. , Nomura H. , Yamada M. , Nakamura S.
      Nucleic Acids Res.14:3167-3179(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor."
      Furutani Y. , Notake M. , Yamayoshi M. , Yamagishi J. , Nomura H. , Ohue M. , Furuta R. , Fukui T. , Yamada M. , Nakamura S.
      Nucleic Acids Res.13:5869-5882(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-114
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-114
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line."
      Nishida T. , Nishino N. , Takano M. , Kawai K. , Bando K. , Masui Y. , Nakai S. , Hirai Y.
      Biochem. Biophys. Res. Commun.143:345-352(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    7. 7.
      "A sequence-based map of the nine genes of the human interleukin-1 cluster."
      Nicklin M.J.H. , Barton J.L. , Nguyen M. , Fitzgerald M.G. , Duff W.G. , Kornman K.
      Genomics79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    8. 8.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    9. 9.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    10. 10.
      SeattleSNPs variation discovery resource
      Submitted (2002-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-85; SER-114 AND ASN-138
    11. 11.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    12. 12.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    14. 14.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    15. 15.
      "Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow."
      Zsebo K.M. , Wypych J. , Yuschenkoff V.N. , Lu H. , Hunt P. , Dukes P.P. , Langley K.E.
      Blood71:962-968(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 113-132
    16. 16.
      "The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece."
      Stevenson F.T. , Bursten S.L. , Fanton C. , Locksley R.M. , Lovett D.H.
      Proc. Natl. Acad. Sci. U.S.A.90:7245-7249(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MYRISTOYLATION AT LYS-82 AND LYS-83
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS)
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