IL1R1 ELISA Kit for Human(Homo sapiens) | EIAab.comIL1R1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > IL1R1(Gene name) > Human

IL1R1 (Gene name),

Interleukin-1 receptor type 1 (Protein name ), IL1R1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IL1R1(IL1R;IL1RA;IL1RT1);

Protein name:

Interleukin-1 receptor type 1(IL-1R-1;IL-1RT-1;IL-1RT1);

Alternative:

Interleukin-1 receptor alpha(IL-1R-alpha);CD121 antigen-like family member A;p80;Interleukin-1 receptor type I;

CD:

CD121a;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds IL1RAP.

Function:

Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

569

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

569:

LLSPATKEKL | QREAHVPLG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07679

STRING:

9606.ENSP00000233946

KEGG:

hsa:3554

MIM:

147810

String:

P14778

UniGene:

Hs.701982

SMR:

P14778

Uniprot:

P14778

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ELISA Kit for Human IL-1R-1

Cat.:

E0065h

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Packing:

96T

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ELISA Kit for Human IL-1R-1

Cat.:

E0065m

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96T

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ELISA Kit for Human IL-1R-1

Cat.:

E0065r

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Packing:

96T

CLIA Kit for Human IL-1R-1

Cat.:

U0065m

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MSDS:

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Packing:

96T

CLIA Kit for Human IL-1R-1

Cat.:

U0065r

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MSDS:

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Packing:

96T

CLIA Kit for Human IL-1R-1

Cat.:

U0065h

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Manual:

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96T

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Polyclonal Antibody for Human IL-1R-1

Cat.:

P0065Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IL-1R-1

Cat.:

P0065Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IL-1R-1

Cat.:

P0065Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IL-1R-1

Protein for Human IL-1R-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Sequence of the cDNA for the human fibroblast type interleukin-1 receptor."
Chua A.O. , Gubler U.
Nucleic Acids Res.17:10114-10114(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

"Cloning the interleukin 1 receptor from human T cells."
Sims J.E. , Acres R.B. , Grubin C.E. , McMahan C.J. , Wignall J.M. , March C.J. , Dower S.K.
Proc. Natl. Acad. Sci. U.S.A.86:8946-8950(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: T-cell.
3.

SeattleSNPs variation discovery resource
Submitted (2002-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-124
4.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
7.

"Specific binding of interleukin 1 (IL-1) beta and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I."
Svenson M. , Hansen M.B. , Heegaard P. , Abell K. , Bendtzen K.
Cytokine5:427-435(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING
8.

"Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses."
Giri J.G. , Wells J. , Dower S.K. , McCall C.E. , Guzman R.N. , Slack J. , Bird T.A. , Shanebeck K. , Grabstein K.H. , Sims J.E. , Alderson M.R.
J. Immunol.153:5802-5809(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND-BINDING
9.

"Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein."
Huang J. , Gao X. , Li S. , Cao Z.
Proc. Natl. Acad. Sci. U.S.A.94:12829-12832(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL1RAP AND IRAK1
tissue: Placenta.
10.

"Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I."
Marmiroli S. , Bavelloni A. , Faenza I. , Sirri A. , Ognibene A. , Cenni V. , Tsukada J. , Koyama Y. , Ruzzene M. , Ferri A. , Auron P.E. , Toker A. , Maraldi N.M.
FEBS Lett.438:49-54(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-496;INTERACTION WITH PIK3R1
11.

"Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways."
Slack J.L. , Schooley K. , Bonnert T.P. , Mitcham J.L. , Qwarnstrom E.E. , Sims J.E. , Dower S.K.
J. Biol. Chem.275:4670-4678(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-369 AND ARG-428
12.

"Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta."
Vigers G.P.A. , Anderson L.J. , Caffes P. , Brandhuber B.J.
Nature386:190-194(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-332 IN COMPLEX WITH IL1B
13.

"A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist."
Schreuder H. , Tardif C. , Trump-Kallmeyer S. , Soffientini A. , Sarubbi E. , Akeson A. , Bowlin T. , Yanofsky S. , Barrett R.W.
Nature386:194-200(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 21-331 IN COMPLEX WITH IL1RA
14.

"X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1."
Vigers G.P.A. , Dripps D.J. , Edwards C.K. III , Brandhuber B.J.
J. Biol. Chem.275:36927-36933(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 4-315 IN COMPLEX WITH THE ANTAGONIST PEPTIDE AF10847

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