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Index > Protein center > IL2RB(Gene name) > Human
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  • IL2RB (Gene name),
  • Interleukin-2 receptor subunit beta (Protein name ),  IL2RB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL2RB;
    Protein name:
    Interleukin-2 receptor subunit beta(IL-2 receptor subunit beta;IL-2R subunit beta;IL-2RB);
    Alternative:
    p70-75(p75);High affinity IL-2 receptor subunit beta;
    CD:
    CD122;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.
    Function:
    Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    551
    Sequence:
    50:
    MAAPALSWRL | PLLILLLPLA | TSWASAAVNG | TSQFTCFYNS | RANISCVWSQ | 
    100:
    DGALQDTSCQ | VHAWPDRRRW | NQTCELLPVS | QASWACNLIL | GAPDSQKLTT | 
    150:
    VDIVTLRVLC | REGVRWRVMA | IQDFKPFENL | RLMAPISLQV | VHVETHRCNI | 
    200:
    SWEISQASHY | FERHLEFEAR | TLSPGHTWEE | APLLTLKQKQ | EWICLETLTP | 
    250:
    DTQYEFQVRV | KPLQGEFTTW | SPWSQPLAFR | TKPAALGKDT | IPWLGHLLVG | 
    300:
    LSGAFGFIIL | VYLLINCRNT | GPWLKKVLKC | NTPDPSKFFS | QLSSEHGGDV | 
    350:
    QKWLSSPFPS | SSFSPGGLAP | EISPLEVLER | DKVTQLLLQQ | DKVPEPASLS | 
    400:
    SNHSLTSCFT | NQGYFFFHLP | DALEIEACQV | YFTYDPYSEE | DPDEGVAGAP | 
    450:
    TGSSPQPLQP | LSGEDDAYCT | FPSRDDLLLF | SPSLLGGPSP | PSTAPGGSGA | 
    500:
    GEERMPPSLQ | ERVPRDWDPQ | PLGPPTPGVP | DLVDFQPPPE | LVLREAGEEV | 
    550:
    PDAGPREGVS | FPWSRPPGQG | EFRALNARLP | LNTDAYLSLQ | ELQGQDPTHL | 
    551:
    V
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    MIM:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-2 receptor subunit beta
    Cat.:
    E1837h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human IL-2 receptor subunit beta
    Cat.:
    E1837m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human IL-2 receptor subunit beta
    Cat.:
    E1837r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-2 receptor subunit beta
    Cat.:
    U1837h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-2 receptor subunit beta
    Cat.:
    U1837m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-2 receptor subunit beta
    Cat.:
    U1837r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human IL-2 receptor subunit beta
    Cat.:
    P1837Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-2 receptor subunit beta
    Cat.:
    P1837Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-2 receptor subunit beta
    Cat.:
    P1837Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-2 receptor subunit beta
    Monoclonal Antibody for Human IL-2 receptor subunit beta
    Monoclonal Antibody for Human IL-2 receptor subunit beta
    Protein for Human IL-2 receptor subunit beta
    Protein for Human IL-2 receptor subunit beta
    Protein for Human IL-2 receptor subunit beta

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's."
      Hatakeyama M. , Tsudo M. , Minamoto S. , Kono T. , Doi T. , Miyata T. , Miyasaka M. , Taniguchi T.
      Science244:551-556(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2002-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PHE-83 AND GLU-391
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Trachea.
    5. 5.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    8. 8.
      "The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface."
      Mulloy J.C. , Crownley R.W. , Fullen J. , Leonard W.J. , Franchini G.
      J. Virol.70:3599-3605(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I
    9. 9.
      "IL-2 receptor signaling through the Shb adapter protein in T and NK cells."
      Lindholm C.K.
      Biochem. Biophys. Res. Commun.296:929-936(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB;MUTAGENESIS OF TYR-418 AND TYR-536
    10. 10.
      "The interleukin-2 and interleukin-4 receptors studied by molecular modelling."
      Bamborough P. , Hedgecock C.J. , Richards W.G.
      Structure2:839-851(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 31-230
    11. 11.
      "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."
      Wang X. , Rickert M. , Garcia K.C.
      Science310:1159-1163(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 27-240 IN COMPLEX WITH IL2; IL2RA AND IL2RC;DISULFIDE BONDS;GLYCOSYLATION AT ASN-149
    12. 12.
      "Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor."
      Stauber D.J. , Debler E.W. , Horton P.A. , Smith K.A. , Wilson I.A.
      Proc. Natl. Acad. Sci. U.S.A.103:2788-2793(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 25-232 IN COMPLEX WITH IL2; IL2RA AND IL2RC;DISULFIDE BONDS;GLYCOSYLATION AT ASN-43; ASN-71 AND ASN-149
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