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Index > Protein center > IL33(Gene name) > Human
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  • IL33 (Gene name),
  • Interleukin-33 (Protein name ),  IL33_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    IL33(C9orf26;IL1F11;NFHEV);
    Protein name:
    Interleukin-33(IL-33);
    Alternative:
    Nuclear factor from high endothelial venules(NF-HEV);Interleukin-1 family member 11(IL-1F11);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T helper type 2-associated cytokines.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    270
    Sequence:
    50:
    MKPKMKYSTN | KISTAKWKNT | ASKALCFKLG | KSQQKAKEVC | PMYFMKLRSG | 
    100:
    LMIKKEACYF | RRETTKRPSL | KTGRKHKRHL | VLAACQQQST | VECFAFGISG | 
    150:
    VQKYTRALHD | SSITGISPIT | EYLASLSTYN | DQSITFALED | ESYEIYVEDL | 
    200:
    KKDEKKDKVL | LSYYESQHPS | NESGDGVDGK | MLMVTLSPTK | DFWLHANNKE | 
    250:
    HSVELHKCEK | PLPDQAFFVL | HNMHSNCVSF | ECKTDPGVFI | GVKDNHLALI | 
    270:
    KVDSSENLCT | ENILFKLSET | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    KEGG:
    UniGene:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-33
    Cat.:
    E1980r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human IL-33
    Cat.:
    E1980m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human IL-33
    Cat.:
    E1980d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human IL-33
    Cat.:
    E1980h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human IL-33
    Cat.:
    U1980h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-33
    Cat.:
    U1980m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-33
    Cat.:
    U1980r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-33
    Cat.:
    U1980d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human IL-33
    Cat.:
    P1980Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-33
    Polyclonal Antibody for Human IL-33
    Cat.:
    P1980Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-33
    Cat.:
    P1980Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-33
    Monoclonal Antibody for Human IL-33
    Monoclonal Antibody for Human IL-33
    Monoclonal Antibody for Human IL-33
    Protein for Human IL-33
    Protein for Human IL-33
    Protein for Human IL-33
    Protein for Human IL-33

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    References
    1. 1.
      "Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases."
      Luthi A.U. , Cullen S.P. , McNeela E.A. , Duriez P.J. , Afonina I.S. , Sheridan C. , Brumatti G. , Taylor R.C. , Kersse K. , Vandenabeele P. , Lavelle E.C. , Martin S.J.
      Immunity31:84-98(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    2. 2.
      "Interleukin-33 is biologically active independently of caspase-1 cleavage."
      Talabot-Ayer D. , Lamacchia C. , Gabay C. , Palmer G.
      J. Biol. Chem.284:19420-19426(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;SUBCELLULAR LOCATION
    3. 3.
      "The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1."
      Cayrol C. , Girard J.P.
      Proc. Natl. Acad. Sci. U.S.A.106:9021-9026(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    4. 4.
      "The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription."
      Ali S. , Mohs A. , Thomas M. , Klare J. , Ross R. , Schmitz M.L. , Martin M.U.
      J. Immunol.187:1609-1616(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    5. 5.
      "Interleukin 33 as a mechanically responsive cytokine secreted by living cells."
      Kakkar R. , Hei H. , Dobner S. , Lee R.T.
      J. Biol. Chem.287:6941-6948(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    6. 6.
      "Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes."
      Lingel A. , Weiss T.M. , Niebuhr M. , Pan B. , Appleton B.A. , Wiesmann C. , Bazan J.F. , Fairbrother W.J.
      Structure17:1398-1410(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 111-270;INTERACTION WITH IL1RL1 AND IL1RAP;SUBUNIT
    7. 7.
      "Structural insights into the interaction of IL-33 with its receptors."
      Liu X. , Hammel M. , He Y. , Tainer J.A. , Jeng U.S. , Zhang L. , Wang S. , Wang X.
      Proc. Natl. Acad. Sci. U.S.A.110:14918-14923(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.27 ANGSTROMS) OF 112-270 IN COMPLEX WITH IL1RL1/ST2;MUTAGENESIS OF GLU-144; GLU-148; ASP-149; GLU-165 AND ASP-244
    8. 8.
      "Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules."
      Baekkevold E.S. , Roussigne M. , Yamanaka T. , Johansen F.-E. , Jahnsen F.L. , Amalric F. , Brandtzaeg P. , Erard M. , Haraldsen G. , Girard J.-P.
      Am. J. Pathol.163:69-79(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Endothelial cell.
    9. 9.
      "Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage."
      Onda H. , Kasuya H. , Takakura K. , Hori T. , Imaizumi T. , Takeuchi T. , Inoue I. , Takeda J.
      J. Cereb. Blood Flow Metab.19:1279-1288(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    10. 10.
      "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."
      Schmitz J. , Owyang A. , Oldham E. , Song Y. , Murphy E. , McClanahan T.K. , Zurawski G. , Moshrefi M. , Qin J. , Li X. , Gorman D.M. , Bazan J.F. , Kastelein R.A.
      Immunity23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING
    11. 11.
      "Identification of constitutively active interleukin 33 (IL-33) splice variant."
      Hong J. , Bae S. , Jhun H. , Lee S. , Choi J. , Kang T. , Kwak A. , Hong K. , Kim E. , Jo S. , Kim S.
      J. Biol. Chem.286:20078-20086(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    12. 12.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4)
      tissue: Adrenal gland.
      tissue: Trachea.
    13. 13.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    14. 14.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    16. 16.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    17. 17.
      "IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G."
      Lefrancais E. , Roga S. , Gautier V. , Gonzalez-de-Peredo A. , Monsarrat B. , Girard J.P. , Cayrol C.
      Proc. Natl. Acad. Sci. U.S.A.109:1673-1678(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 95-121;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;PROTEOLYTIC PROCESSING;CLEAVAGE AT PHE-94 AND LEU-108 BY CSTG;CLEAVAGE AT ILE-98 BY ELANE
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    19. 19.
      "IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo."
      Carriere V. , Roussel L. , Ortega N. , Lacorre D.A. , Americh L. , Aguilar L. , Bouche G. , Girard J.P.
      Proc. Natl. Acad. Sci. U.S.A.104:282-287(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;NUCLEAR TARGETING DOMAIN
    20. 20.
      "Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation."
      Kuchler A.M. , Pollheimer J. , Balogh J. , Sponheim J. , Manley L. , Sorensen D.R. , De Angelis P.M. , Scott H. , Haraldsen G.
      Am. J. Pathol.173:1229-1242(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    21. 21.
      "The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?"
      Moussion C. , Ortega N. , Girard J.P.
      PLoS ONE3:E3331-E3331(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    22. 22.
      "Mature interleukin-33 is produced by calpain-mediated cleavage in vivo."
      Hayakawa M. , Hayakawa H. , Matsuyama Y. , Tamemoto H. , Okazaki H. , Tominaga S.
      Biochem. Biophys. Res. Commun.387:218-222(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
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