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Index > Protein center > IL36B(Gene name) > Human
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  • IL36B (Gene name),
  • Interleukin-36 beta (Protein name ),  IL36B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    IL36B(IL1F8;IL1H2);
    Protein name:
    Interleukin-36 beta;
    Alternative:
    Interleukin-1 eta(IL-1 eta);FIL1 eta;Interleukin-1 homolog 2(IL-1H2);Interleukin-1 family member 8(IL-1F8);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    164
    Sequence:
    50:
    MNPQREAAPK | SYAIRDSRQM | VWVLSGNSLI | AAPLSRSIKP | VTLHLIACRD | 
    100:
    TEFSDKEKGN | MVYLGIKGKD | LCLFCAEIQG | KPTLQLKLQG | SQDNIGKDTC | 
    150:
    WKLVGIHTCI | NLDVRESCFM | GTLDQWGIGV | GRKKWKSSFQ | HHHLRKKDKD | 
    164:
    FSSMRTNIGM | PGRM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Interleukin-36 beta
    Cat.:
    E2013h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Interleukin-36 beta
    Cat.:
    E2013m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Interleukin-36 beta
    Cat.:
    U2013h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Interleukin-36 beta
    Cat.:
    U2013m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Interleukin-36 beta
    Cat.:
    P2013Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Interleukin-36 beta
    Cat.:
    P2013Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Interleukin-36 beta
    Monoclonal Antibody for Human Interleukin-36 beta
    Protein for Human Interleukin-36 beta
    Protein for Human Interleukin-36 beta

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification and initial characterization of four novel members of the interleukin-1 family."
      Kumar S. , McDonnell P.C. , Lehr R. , Tierney L. , Tzimas M.N. , Griswold D.E. , Capper E.A. , Tal-Singer R. , Wells G.I. , Doyle M.L. , Young P.R.
      J. Biol. Chem.275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Osteoclastoma.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "A sequence-based map of the nine genes of the human interleukin-1 cluster."
      Nicklin M.J.H. , Barton J.L. , Nguyen M. , Fitzgerald M.G. , Duff W.G. , Kornman K.
      Genomics79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT CYS-36
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Lung.
      tissue: Placenta.
    8. 8.
      "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes."
      Magne D. , Palmer G. , Barton J.L. , Mezin F. , Talabot-Ayer D. , Bas S. , Duffy T. , Noger M. , Guerne P.A. , Nicklin M.J. , Gabay C.
      Arthritis Res. Ther.8:R80-R80(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;SUBCELLULAR LOCATION
    9. 9.
      "The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation."
      van Asseldonk E.J. , Stienstra R. , Koenen T.B. , van Tits L.J. , Joosten L.A. , Tack C.J. , Netea M.G.
      Obesity18:2234-2236(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    10. 10.
      "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."
      Towne J.E. , Renshaw B.R. , Douangpanya J. , Lipsky B.P. , Shen M. , Gabel C.A. , Sims J.E.
      J. Biol. Chem.286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROCESSING
    11. 11.
      "IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression."
      Johnston A. , Xing X. , Guzman A.M. , Riblett M. , Loyd C.M. , Ward N.L. , Wohn C. , Prens E.P. , Wang F. , Maier L.E. , Kang S. , Voorhees J.J. , Elder J.T. , Gudjonsson J.E.
      J. Immunol.186:2613-2622(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    12. 12.
      "Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis."
      Carrier Y. , Ma H.L. , Ramon H.E. , Napierata L. , Small C. , O'Toole M. , Young D.A. , Fouser L.A. , Nickerson-Nutter C. , Collins M. , Dunussi-Joannopoulos K. , Medley Q.G.
      J. Invest. Dermatol.131:2428-2437(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin."
      Foster A.M. , Baliwag J. , Chen C.S. , Guzman A.M. , Stoll S.W. , Gudjonsson J.E. , Ward N.L. , Johnston A.
      J. Immunol.192:6053-6061(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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