Il4r ELISA Kit for Mouse(Mus musculus) | EIAab.comIl4r ELISA Kit for Mouse(Mus musculus)

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Il4r (Gene name),

Interleukin-4 receptor subunit alpha (Protein name ), IL4RA_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Il4r(Il4ra);

Protein name:

Interleukin-4 receptor subunit alpha(IL-4 receptor subunit alpha;IL-4R subunit alpha;IL-4R-alpha;IL-4RA);

Alternative:

CD:

CD124;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region. In Th1 cells, binds the N-terminal 50 amino acids of SOCS5, which inhibits JAK1 interaction, STAT6 activation and Th2 cell differentiation. SOCS5 interaction is independent of tyrosine phosphorylation.

Function:

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

Subcellular Location:

Isoform 2 Secreted

Protein Attributes:

Sequence length:

810

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

810:

PVGALGIAVS |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF09238

KEGG:

mmu:16190

SMR:

P16382

String:

P16382

UniGene:

Mm.233802

Uniprot:

P16382

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ELISA Kit for Mouse IL-4 receptor subunit alpha

Cat.:

E2031h

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96T

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ELISA Kit for Mouse IL-4 receptor subunit alpha

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E2031m

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96T

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ELISA Kit for Mouse IL-4 receptor subunit alpha

Cat.:

E2031r

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96T

ELISA Kit for Mouse IL-4 receptor subunit alpha

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E2031p

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96T

CLIA Kit for Mouse IL-4 receptor subunit alpha

Cat.:

U2031r

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Packing:

96T

CLIA Kit for Mouse IL-4 receptor subunit alpha

Cat.:

U2031m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse IL-4 receptor subunit alpha

Cat.:

U2031p

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse IL-4 receptor subunit alpha

Cat.:

U2031h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Mouse IL-4 receptor subunit alpha

Cat.:

P2031Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse IL-4 receptor subunit alpha

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P2031Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse IL-4 receptor subunit alpha

Cat.:

P2031Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse IL-4 receptor subunit alpha

Protein for Mouse IL-4 receptor subunit alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms."
Mosley B. , Beckmann M.P. , March C.J. , Idzerda R.L. , Gimpel S.D. , VandenBos T. , Friend D. , Alpert A. , Anderson D. , Jackson J. , Wignall J.M. , Smith C. , Gallis B. , Sims J.E. , Urdal D. , Widmer M.B. , Cosman D. , Park L.S.
Cell59:335-348(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);PROTEIN SEQUENCE OF 26-39; 162-179 AND 194-210
strain: C57BL/6.
tissue: T-cell.
2.

"Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding."
Harada N. , Castle B.E. , Gorman D.M. , Itoh N. , Schreurs J. , Barrett R.L. , Howard M. , Miyajima A.
Proc. Natl. Acad. Sci. U.S.A.87:857-861(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: C57BL/6.
tissue: Mast cell.
3.

"The murine interleukin-4 receptor gene: genomic structure, expression and potential for alternative splicing."
Wrighton N. , Campbell L.A. , Harada N. , Miyajima A. , Lee F.
Growth Factors6:103-118(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
strain: BALB/c.
tissue: Sperm.
4.

"Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes."
Schulte T. , Kurrle R. , Roellinghoff M. , Gessner A.
J. Exp. Med.186:1419-1429(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION OF VARIANT ILE-74
strain: AKR/J.
strain: BALB/c.
strain: C3H/HeN.
strain: C57BL/6.
strain: CB-17/SCID.
strain: CBA.
strain: DBA/2.
strain: FVB/N.
strain: SJL/J.
5.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6J.
tissue: Diencephalon.
tissue: Thymus.
6.

"Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation."
Seki Y. , Hayashi K. , Matsumoto A. , Seki N. , Tsukada J. , Ransom J. , Naka T. , Kishimoto T. , Yoshimura A. , Kubo M.
Proc. Natl. Acad. Sci. U.S.A.99:13003-13008(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAK1 AND SOCS5
7.

"Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2."
Izuhara K. , Harada N.
J. Biol. Chem.268:13097-13102(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH PIK3C3
8.

"Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor."
Blum H. , Wolf M. , Enssle K. , Roellinghoff M. , Gessner A.
J. Immunol.157:1846-1853(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
9.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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