Protein name:
Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha;IL-7R subunit alpha;IL-7R-alpha;IL-7RA) ;
Alternative:
CDw127 ;
CD:
CD127 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
The IL7 receptor is an heterodimer of IL7R and IL2RG. The TSLP receptor is an heterodimer of CRLF2 and IL7R.
Function:
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Subcellular Location:
Isoform 4
Secreted
Protein Attributes:
50:
MTILGTTFGM | VFSLLQVVSG | ESGYAQNGDL | EDAELDDYSF | SCYSQLEVNG |
100:
SQHSLTCAFE | DPDVNTTNLE | FEICGALVEV | KCLNFRKLQE | IYFIETKKFL |
150:
LIGKSNICVK | VGEKSLTCKK | IDLTTIVKPE | APFDLSVIYR | EGANDFVVTF |
200:
NTSHLQKKYV | KVLMHDVAYR | QEKDENKWTH | VNLSSTKLTL | LQRKLQPAAM |
250:
YEIKVRSIPD | HYFKGFWSEW | SPSYYFRTPE | INNSSGEMDP | ILLTISILSF |
300:
FSVALLVILA | CVLWKKRIKP | IVWPSLPDHK | KTLEHLCKKP | RKNLNVSFNP |
350:
ESFLDCQIHR | VDDIQARDEV | EGFLQDTFPQ | QLEESEKQRL | GGDVQSPNCP |
400:
SEDVVITPES | FGRDSSLTCL | AGNVSACDAP | ILSSSRSLDC | RESGKNGPHV |
450:
YQDLLLSLGT | TNSTLPPPFS | LQSGILTLNP | VAQGQPILTS | LGSNQEEAYV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human IL-7 receptor subunit alpha
ELISA Kit for Human IL-7 receptor subunit alpha
CLIA Kit for Human IL-7 receptor subunit alpha
CLIA Kit for Human IL-7 receptor subunit alpha
Polyclonal Antibody for Human IL-7 receptor subunit alpha
Polyclonal Antibody for Human IL-7 receptor subunit alpha
Monoclonal Antibody for Human IL-7 receptor subunit alpha
Monoclonal Antibody for Human IL-7 receptor subunit alpha
Protein for Human IL-7 receptor subunit alpha
Protein for Human IL-7 receptor subunit alpha
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
"Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily."
Goodwin R.G.
,
Friend D.
,
Ziegler S.F.
,
Jerzy R.
,
Falk B.A.
,
Gimpel S.
,
Cosman D.
,
Dower S.K.
,
March C.J.
,
Namen A.E.
,
Park L.S.
Cell60:941-951(1990)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING;VARIANT VAL-356
tissue :
B-cell .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANT VAL-356
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138;VARIANT ILE-244
4.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4);VARIANT VAL-356
tissue :
Spleen .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138;VARIANTS ASP-113 AND ILE-244
6.
"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J.
,
Martin J.
,
Terry A.
,
Couronne O.
,
Grimwood J.
,
Lowry S.
,
Gordon L.A.
,
Scott D.
,
Xie G.
,
Huang W.
,
Hellsten U.
,
Tran-Gyamfi M.
,
She X.
,
Prabhakar S.
,
Aerts A.
,
Altherr M.
,
Bajorek E.
,
Black S.
,
Branscomb E.
,
Caoile C.
,
Challacombe J.F.
,
Chan Y.M.
,
Denys M.
,
Detter J.C.
,
Escobar J.
,
Flowers D.
,
Fotopulos D.
,
Glavina T.
,
Gomez M.
,
Gonzales E.
,
Goodstein D.
,
Grigoriev I.
,
Groza M.
,
Hammon N.
,
Hawkins T.
,
Haydu L.
,
Israni S.
,
Jett J.
,
Kadner K.
,
Kimball H.
,
Kobayashi A.
,
Lopez F.
,
Lou Y.
,
Martinez D.
,
Medina C.
,
Morgan J.
,
Nandkeshwar R.
,
Noonan J.P.
,
Pitluck S.
,
Pollard M.
,
Predki P.
,
Priest J.
,
Ramirez L.
,
Retterer J.
,
Rodriguez A.
,
Rogers S.
,
Salamov A.
,
Salazar A.
,
Thayer N.
,
Tice H.
,
Tsai M.
,
Ustaszewska A.
,
Vo N.
,
Wheeler J.
,
Wu K.
,
Yang J.
,
Dickson M.
,
Cheng J.-F.
,
Eichler E.E.
,
Olsen A.
,
Pennacchio L.A.
,
Rokhsar D.S.
,
Richardson P.
,
Lucas S.M.
,
Myers R.M.
,
Rubin E.M.
more...
Nature431:268-274(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138;VARIANT VAL-356
tissue :
Testis .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 21-239 IN COMPLEX WITH IL7;SUBUNIT;GLYCOSYLATION AT ASN-49; ASN-65 AND ASN-151;DISULFIDE BONDS
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT T(-)/B(+)/NK(+) SCID SER-132
10.
"Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis."
Gregory S.G.
,
Schmidt S.
,
Seth P.
,
Oksenberg J.R.
,
Hart J.
,
Prokop A.
,
Caillier S.J.
,
Ban M.
,
Goris A.
,
Barcellos L.F.
,
Lincoln R.
,
McCauley J.L.
,
Sawcer S.J.
,
Compston D.A.
,
Dubois B.
,
Hauser S.L.
,
Garcia-Blanco M.A.
,
Pericak-Vance M.A.
,
Haines J.L.
more...
Nat. Genet.39:1083-1091(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ILE-244;ASSOCIATION WITH MS3