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Index > Protein center > SERPINB1(Gene name) > Human
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  • SERPINB1 (Gene name),
  • Leukocyte elastase inhibitor (Protein name ),  ILEU_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SERPINB1(ELANH2;MNEI;PI2);
    Protein name:
    Leukocyte elastase inhibitor(LEI);
    Alternative:
    Peptidase inhibitor 2(PI-2);Monocyte/neutrophil elastase inhibitor(EI;M/NEI);Serpin B1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    379
    Sequence:
    50:
    MEQLSSANTR | FALDLFLALS | ENNPAGNIFI | SPFSISSAMA | MVFLGTRGNT | 
    100:
    AAQLSKTFHF | NTVEEVHSRF | QSLNADINKR | GASYILKLAN | RLYGEKTYNF | 
    150:
    LPEFLVSTQK | TYGADLASVD | FQHASEDARK | TINQWVKGQT | EGKIPELLAS | 
    200:
    GMVDNMTKLV | LVNAIYFKGN | WKDKFMKEAT | TNAPFRLNKK | DRKTVKMMYQ | 
    250:
    KKKFAYGYIE | DLKCRVLELP | YQGEELSMVI | LLPDDIEDES | TGLKKIEEQL | 
    300:
    TLEKLHEWTK | PENLDFIEVN | VSLPRFKLEE | SYTLNSDLAR | LGVQDLFNSS | 
    350:
    KADLSGMSGA | RDIFISKIVH | KSFVEVNEEG | TEAAAATAGI | ATFCMLMPEE | 
    379:
    NFTADHPFLF | FIRHNSSGSI | LFLGRFSSP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    UniGene:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human LEI
    Cat.:
    E9678p
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Human LEI
    Cat.:
    E9678h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human LEI
    Cat.:
    E9678b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LEI
    Cat.:
    U9678b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LEI
    Cat.:
    U9678p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LEI
    Cat.:
    U9678h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human LEI
    Cat.:
    P9678Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LEI
    Polyclonal Antibody for Human LEI
    Monoclonal Antibody for Human LEI
    Monoclonal Antibody for Human LEI
    Monoclonal Antibody for Human LEI
    Protein for Human LEI
    Protein for Human LEI
    Protein for Human LEI

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor."
      Remold-O'Donnell E. , Chin J. , Alberts M.
      Proc. Natl. Acad. Sci. U.S.A.89:5635-5639(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene."
      Zeng W. , Silverman G.A. , Remold-O'Donnell E.
      Gene213:179-187(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Lung.
      tissue: Tongue.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Small intestine.
    6. 6.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cervix.
    8. 8.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-10;ACETYLATION AT MET-1
      tissue: Platelet.
    9. 9.
      "A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes."
      Packard B.Z. , Lee S.S. , Remold-O'Donnell E. , Komoriya A.
      Biochim. Biophys. Acta1269:41-50(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 111-129; 216-244 AND 255-274
    10. 10.
      "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
      Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 178-185; 204-210 AND 364-371
      tissue: Keratinocyte.
    11. 11.
      "The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites."
      Cooley J. , Takayama T.K. , Shapiro S.D. , Schechter N.M. , Remold-O'Donnell E.
      Biochemistry40:15762-15770(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;REACTIVE SITES;IDENTIFICATION BY MASS SPECTROMETRY
    12. 12.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-137 AND LYS-177;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Identification of SERPINB1 as a physiological inhibitor of human granzyme H."
      Wang L. , Li Q. , Wu L. , Liu S. , Zhang Y. , Yang X. , Zhu P. , Zhang H. , Zhang K. , Lou J. , Liu P. , Tong L. , Sun F. , Fan Z.
      J. Immunol.190:1319-1330(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) IN COMPLEX WITH GZMH;SUBCELLULAR LOCATION;SUBUNIT
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