Kpna1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comKpna1 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Kpna1(Gene name) > Rat

Kpna1 (Gene name),

Importin subunit alpha-1 (Protein name ), IMA1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Kpna1;

Protein name:

Importin subunit alpha-1;

Alternative:

Karyopherin subunit alpha-1;Importin alpha-5;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms a complex with importin subunit beta-1. Interacts with ANP32E. Interacts with APEX1 (via N-terminus). Interacts with ZIC3.

Function:

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

538

Sequence:

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