IMPA1 ELISA Kit for Human(Homo sapiens) | EIAab.comIMPA1 ELISA Kit for Human(Homo sapiens)

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IMPA1 (Gene name),

Inositol monophosphatase 1 (Protein name ), IMPA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IMPA1(IMPA);

Protein name:

Inositol monophosphatase 1(IMP 1;IMPase 1);

Alternative:

Lithium-sensitive myo-inositol monophosphatase A1;Inositol-1(or 4)-monophosphatase 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

277

Sequence:

50:

100:

150:

200:

250:

277:

IAANNRILAE | RIAKEIQVIP | LQRDDED

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

602064

Pfam:

PF00459

UniGene:

Hs.656694

SMR:

P29218

STRING:

9606.ENSP00000408526

KEGG:

hsa:3612

String:

P29218

Uniprot:

P29218

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ELISA Kit for Human IMP 1

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E1404h

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96T

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ELISA Kit for Human IMP 1

Cat.:

E1404b

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96T

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ELISA Kit for Human IMP 1

Cat.:

E1404p

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96T

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ELISA Kit for Human IMP 1

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E1404r

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96T

ELISA Kit for Human IMP 1

Cat.:

E1404m

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96T

CLIA Kit for Human IMP 1

Cat.:

U1404r

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96T

CLIA Kit for Human IMP 1

Cat.:

U1404b

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96T

CLIA Kit for Human IMP 1

Cat.:

U1404p

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Packing:

96T

CLIA Kit for Human IMP 1

Cat.:

U1404h

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Packing:

96T

CLIA Kit for Human IMP 1

Cat.:

U1404m

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96T

Polyclonal Antibody for Human IMP 1

Cat.:

P1404Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human IMP 1

Cat.:

P1404Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human IMP 1

Cat.:

P1404Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human IMP 1

Monoclonal Antibody for Human IMP 1

Protein for Human IMP 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme."
McAllister G. , Whiting P. , Hammond E.A. , Knowles M.R. , Atack J.R. , Bailey F.J. , Maigetter R. , Ragan C.I.
Biochem. J.284:749-754(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY
tissue: Hippocampus.
2.

"Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA)."
Sjoeholt G. , Molven A. , Loevlie R. , Wilcox A. , Sikela J.M. , Steen V.M.
Genomics45:113-122(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Molecular cloning and expression of human cerebral cortex myo-inositol monophosphatase A1 cDNA."
Parthasarathy R. , Parthasarathy L. , Vadnal R.E.
Submitted (1998-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
tissue: Thymus.
tissue: Umbilical cord blood.
5.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Urinary bladder.
8.

"Molecular cloning, genomic organization and promoter analysis of the human brain lithium-sensitive myo-inositol monophosphatase A1 isoenzyme."
Parthasarathy L. , Parthasarathy R.
Submitted (2000-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20
9.

"Brain inositol monophosphatase identified as a galactose 1-phosphatase."
Parthasarathy R. , Parthasarathy L. , Vadnal R.
Brain Res.778:99-106(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;COFACTOR;ENZYME REGULATION;SUBUNIT
10.

"Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1."
Ohnishi T. , Ohba H. , Seo K.-C. , Im J. , Sato Y. , Iwayama Y. , Furuichi T. , Chung S.-K. , Yoshikawa T.
J. Biol. Chem.282:637-646(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-93
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
13.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Structure of inositol monophosphatase, the putative target of lithium therapy."
Bone R. , Springer J.P. , Atack J.R.
Proc. Natl. Acad. Sci. U.S.A.89:10031-10035(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH GADOLINIUM IONS;METAL-BINDING SITE;SUBUNIT
15.

"Structural analysis of inositol monophosphatase complexes with substrates."
Bone R. , Frank L. , Springer J.P. , Pollack S.J. , Osborne S.A. , Atack J.R. , Knowles M.R. , McAllister G. , Ragan C.I. , Broughton H.B.
Biochemistry33:9460-9467(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH MYO-INOSITOL 1-PHOSPHATE AND GADOLINIUM ION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;METAL-BINDING SITE;MUTAGENESIS OF SER-165 AND GLU-213
16.

"Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis."
Bone R. , Frank L. , Springer J.P. , Atack J.R.
Biochemistry33:9468-9476(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEXES WITH SUBSTRATE ANALOG AND MANGANESE;COFACTOR
17.

"The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase."
Ganzhorn A.J. , Lepage P. , Pelton P.D. , Strasser F. , Vincendon P. , Rondeau J.-M.
Biochemistry35:10957-10966(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF MUTANT GLN-36;MUTAGENESIS OF LYS-36;CATALYTIC ACTIVITY;FUNCTION;COFACTOR;ENZYME REGULATION
18.

"Structure of an enzyme-substrate complex and the catalytic mechanism of human brain myo-inositol monophosphatase."
Ganzhorn A.J. , Rondeau J.-M.
Protein Eng.10:61-70(1997)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH 1D-MYO-INOSITOL 1-PHOSPHATE AND CALCIUM;METAL-BINDING SITE
19.

"Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens."
Singh N. , Halliday A.C. , Knight M. , Lack N.A. , Lowe E. , Churchill G.C.
Acta Crystallogr. F68:1149-1152(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH MAGNESIUM;COFACTOR;SUBUNIT

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