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Index > Protein center > IMPA1(Gene name) > Human
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  • IMPA1 (Gene name),
  • Inositol monophosphatase 1 (Protein name ),  IMPA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    IMPA1(IMPA);
    Protein name:
    Inositol monophosphatase 1(IMP 1;IMPase 1);
    Alternative:
    Lithium-sensitive myo-inositol monophosphatase A1;Inositol-1(or 4)-monophosphatase 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    277
    Sequence:
    50:
    MADPWQECMD | YAVTLARQAG | EVVCEAIKNE | MNVMLKSSPV | DLVTATDQKV | 
    100:
    EKMLISSIKE | KYPSHSFIGE | ESVAAGEKSI | LTDNPTWIID | PIDGTTNFVH | 
    150:
    RFPFVAVSIG | FAVNKKIEFG | VVYSCVEGKM | YTARKGKGAF | CNGQKLQVSQ | 
    200:
    QEDITKSLLV | TELGSSRTPE | TVRMVLSNME | KLFCIPVHGI | RSVGTAAVNM | 
    250:
    CLVATGGADA | YYEMGIHCWD | VAGAGIIVTE | AGGVLMDVTG | GPFDLMSRRV | 
    277:
    IAANNRILAE | RIAKEIQVIP | LQRDDED
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human IMP 1
    Cat.:
    E1404h
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    ELISA Kit for Human IMP 1
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    E1404b
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    96T
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    ELISA Kit for Human IMP 1
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    E1404p
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    ELISA Kit for Human IMP 1
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    E1404r
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    ELISA Kit for Human IMP 1
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    E1404m
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    96T
    CLIA Kit for Human IMP 1
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    U1404r
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    96T
    CLIA Kit for Human IMP 1
    Cat.:
    U1404b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human IMP 1
    Cat.:
    U1404p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human IMP 1
    Cat.:
    U1404h
    Price:
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    MSDS:
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    Packing:
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    CLIA Kit for Human IMP 1
    Cat.:
    U1404m
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    Packing:
    96T
    Polyclonal Antibody for Human IMP 1
    Cat.:
    P1404Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IMP 1
    Cat.:
    P1404Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IMP 1
    Cat.:
    P1404Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IMP 1
    Polyclonal Antibody for Human IMP 1
    Monoclonal Antibody for Human IMP 1
    Monoclonal Antibody for Human IMP 1
    Monoclonal Antibody for Human IMP 1
    Monoclonal Antibody for Human IMP 1
    Monoclonal Antibody for Human IMP 1
    Protein for Human IMP 1
    Protein for Human IMP 1
    Protein for Human IMP 1
    Protein for Human IMP 1
    Protein for Human IMP 1

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    References
    1. 1.
      "cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme."
      McAllister G. , Whiting P. , Hammond E.A. , Knowles M.R. , Atack J.R. , Bailey F.J. , Maigetter R. , Ragan C.I.
      Biochem. J.284:749-754(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY
      tissue: Hippocampus.
    2. 2.
      "Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA)."
      Sjoeholt G. , Molven A. , Loevlie R. , Wilcox A. , Sikela J.M. , Steen V.M.
      Genomics45:113-122(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Molecular cloning and expression of human cerebral cortex myo-inositol monophosphatase A1 cDNA."
      Parthasarathy R. , Parthasarathy L. , Vadnal R.E.
      Submitted (1998-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Thymus.
      tissue: Umbilical cord blood.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Urinary bladder.
    7. 8.
      "Molecular cloning, genomic organization and promoter analysis of the human brain lithium-sensitive myo-inositol monophosphatase A1 isoenzyme."
      Parthasarathy L. , Parthasarathy R.
      Submitted (2000-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20
    8. 9.
      "Brain inositol monophosphatase identified as a galactose 1-phosphatase."
      Parthasarathy R. , Parthasarathy L. , Vadnal R.
      Brain Res.778:99-106(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;COFACTOR;ENZYME REGULATION;SUBUNIT
    9. 10.
      "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1."
      Ohnishi T. , Ohba H. , Seo K.-C. , Im J. , Sato Y. , Iwayama Y. , Furuichi T. , Chung S.-K. , Yoshikawa T.
      J. Biol. Chem.282:637-646(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-93
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 12.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 14.
      "Structure of inositol monophosphatase, the putative target of lithium therapy."
      Bone R. , Springer J.P. , Atack J.R.
      Proc. Natl. Acad. Sci. U.S.A.89:10031-10035(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH GADOLINIUM IONS;METAL-BINDING SITE;SUBUNIT
    14. 15.
      "Structural analysis of inositol monophosphatase complexes with substrates."
      Bone R. , Frank L. , Springer J.P. , Pollack S.J. , Osborne S.A. , Atack J.R. , Knowles M.R. , McAllister G. , Ragan C.I. , Broughton H.B.
      Biochemistry33:9460-9467(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH MYO-INOSITOL 1-PHOSPHATE AND GADOLINIUM ION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;METAL-BINDING SITE;MUTAGENESIS OF SER-165 AND GLU-213
    15. 16.
      "Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis."
      Bone R. , Frank L. , Springer J.P. , Atack J.R.
      Biochemistry33:9468-9476(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEXES WITH SUBSTRATE ANALOG AND MANGANESE;COFACTOR
    16. 17.
      "The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase."
      Ganzhorn A.J. , Lepage P. , Pelton P.D. , Strasser F. , Vincendon P. , Rondeau J.-M.
      Biochemistry35:10957-10966(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF MUTANT GLN-36;MUTAGENESIS OF LYS-36;CATALYTIC ACTIVITY;FUNCTION;COFACTOR;ENZYME REGULATION
    17. 18.
      "Structure of an enzyme-substrate complex and the catalytic mechanism of human brain myo-inositol monophosphatase."
      Ganzhorn A.J. , Rondeau J.-M.
      Protein Eng.10:61-70(1997)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH 1D-MYO-INOSITOL 1-PHOSPHATE AND CALCIUM;METAL-BINDING SITE
    18. 19.
      "Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens."
      Singh N. , Halliday A.C. , Knight M. , Lack N.A. , Lowe E. , Churchill G.C.
      Acta Crystallogr. F68:1149-1152(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH MAGNESIUM;COFACTOR;SUBUNIT
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