Insig2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comInsig2 ELISA Kit for Rat(Rattus norvegicus)

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Insig2 (Gene name),

Insulin-induced gene 2 protein (Protein name ), INSI2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Insig2;

Protein name:

Insulin-induced gene 2 protein(INSIG-2);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139.

Function:

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

225

Sequence:

50:

100:

150:

200:

225:

ITMGNIGRQL | AMYECKVIAE | KSHQE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:288985

UniGene:

Rn.16736

String:

Q80UA9

Pfam:

PF07281

STRING:

10116.ENSRNOP00000003391

Uniprot:

Q80UA9

FOR

ELISA Kit for Rat INSIG-2

CLIA Kit for Rat INSIG-2

Polyclonal Antibody for Rat INSIG-2

Monoclonal Antibody for Rat INSIG-2

Protein for Rat INSIG-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis."
Yabe D. , Komuro R. , Liang G. , Goldstein J.L. , Brown M.S.
Proc. Natl. Acad. Sci. U.S.A.100:3155-3160(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Heart.

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