Gene name:
    INSL5 (UNQ156/PRO182) ;
    
 
    Protein name:
    Insulin-like peptide INSL5 (Insulin-like peptide 5) ;
    
    Alternative:
    
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Sub Unit:
    Heterodimer of a B chain and an A chain linked by two disulfide bonds.
    
 
    Function:
    May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Secreted 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MKGSIFTLFL |  FSVLFAISEV |  RSKESVRLCG |  LEYIRTVIYI |  CASSRWRRHQ |  
    
 
    100:
    EGIPQAQQAE |  TGNSFQLPHK |  REFSEENPAQ |  NLPKVDASGE |  DRLWGGQMPT |  
    
 
    135:
    EELWKSKKHS |  VMSRQDLQTL |  CCTDGCSMTD |  LSALC
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Mouse
         
        
        Human
         
        
     
    
        ELISA Kit for Human Insulin-like peptide 5
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human Insulin-like peptide 5
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human Insulin-like peptide 5
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human Insulin-like peptide 5
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Insulin-like peptide 5
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Insulin-like peptide 5
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Insulin-like peptide 5
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Insulin-like peptide 5
        
     
    
    
    
    
    
    
 
    
        Protein for Human Insulin-like peptide 5
        
     
    
    
    
    
    
    
 
    
        Protein for Human Insulin-like peptide 5
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Precision
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Recovery
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Linearity
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    
    
    References
    
    
        
            
        
            
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                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANT LEU-50 
                    
                    
                    tissue :
                    
Colon .  
             
         
            
        
            
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                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LEU-50 
                    
                    
                 
             
         
            
        
            
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Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LEU-50 
                    
                    
                    tissue :
                    
Brain .  
             
         
            
        
            
                5.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PROTEIN SEQUENCE OF 23-37 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                        
                            "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)." 
                        
                        
                            Liu C. 
                        ,
                            
Kuei C. 
                        ,
                            
Sutton S. 
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Chen J. 
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Bonaventure P. 
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                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for BINDING TO RXFP4 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                        
                            "Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5)." 
                        
                        
                            Akhter Hossain M. 
                        ,
                            
Bathgate R.A.D. 
                        ,
                            
Kong C.K. 
                        ,
                            
Shabanpoor F. 
                        ,
                            
Zhang S. 
                        ,
                            
Haugaard-Joensson L.M. 
                        ,
                            
Rosengren K.J. 
                        ,
                            
Tregear G.W. 
                        ,
                            
Wade J.D. 
                        
                        
                        
                        
                            ChemBioChem9:1816-1822(2008)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for SYNTHESIS OF 23-46 AND 115-135;DISULFIDE BONDS;PYROGLUTAMATE FORMATION AT GLN-115 
                    
                    
                 
             
         
            
        
            
                8.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for STRUCTURE BY NMR OF 23-46 AND 115-135