INSR ELISA Kit for Human(Homo sapiens) | EIAab.comINSR ELISA Kit for Human(Homo sapiens)

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INSR (Gene name),

Insulin receptor (Protein name ), INSR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

INSR;

Protein name:

Insulin receptor(IR);

Alternative:

CD:

CD220;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Interacts with SORBS1 but dissociates from it following insulin stimulation. Binds SH2B2. Interacts with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. The sequences surrounding the phosphorylated NPXY motif contribute differentially to either IRS1 or SHC1 recognition. Interacts with the SH2 domains of the 85 kDa regulatory subunit of PI3K (PIK3R1) in vitro, when autophosphorylated on tyrosine residues. Interacts with SOCS7. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with CAV2 (tyrosine-phosphorylated form); the interaction is increased with 'Tyr-27'phosphorylation of CAV2. Interacts with ARRB2 (By similarity). Interacts with GRB10; this interaction blocks the association between IRS1/IRS2 and INSR, significantly reduces insulin-stimulated tyrosine phosphorylation of IRS1 and IRS2 and thus decreases insulin signaling. Interacts with GRB7.

Function:

This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1382

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1382:

FKRSYEEHIP | YTHMNGGKKN | GRILTLPRSN | PS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P06213

STRING:

9606.ENSP00000303830

UniGene:

Hs.465744

MIM:

125853

Pfam:

PF00041

KEGG:

hsa:3643

String:

P06213

Uniprot:

P06213

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ELISA Kit for Human IR

Cat.:

E0895h

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96T

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ELISA Kit for Human IR

Cat.:

E0895m

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96T

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ELISA Kit for Human IR

Cat.:

E0895r

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96T

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CLIA Kit for Human IR

Cat.:

U0895m

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MSDS:

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Packing:

96T

CLIA Kit for Human IR

Cat.:

U0895h

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MSDS:

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Packing:

96T

CLIA Kit for Human IR

Cat.:

U0895r

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Packing:

96T

Polyclonal Antibody for Human IR

Cat.:

P0895Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human IR

Cat.:

P0895Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human IR

Cat.:

P0895Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IR

Protein for Human IR

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling."
Ebina Y. , Ellis L. , Jarnagin K. , Edery M. , Graf L. , Clauser E. , Ou J.-H. , Masiarz F. , Kan Y.W. , Goldfine I.D. , Roth R.A. , Rutter W.J.
Cell40:747-758(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);VARIANTS GLY-2; HIS-171; THR-448 AND LYS-492
2.

"Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes."
Ullrich A. , Bell J.R. , Chen E.Y. , Herrera R. , Petruzzelli L.M. , Dull T.J. , Gray A. , Coussens L. , Liao Y.-C. , Tsubokawa M. , Mason A. , Seeburg P.H. , Grunfeld C. , Rosen O.M. , Ramachandran J.
Nature313:756-761(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);PROTEIN SEQUENCE OF 28-49 AND 763-782;GLYCOSYLATION AT ASN-43 AND ASN-769;VARIANT GLY-2
3.

Chen E.Y.
Submitted (1985-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 899-900
4.

"Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction."
Seino S. , Seino M. , Bell G.I.
Diabetes39:123-128(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-2
tissue: Fetal liver.
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT);VARIANT GLY-2
7.

"Characterization of the promoter region of the human insulin receptor gene. Evidence for promoter activity."
Araki E. , Shimada F. , Uzawa H. , Mori M. , Ebina Y.
J. Biol. Chem.262:16186-16191(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33;VARIANT GLY-2
8.

"Characterization of the promoter region of the human insulin receptor gene."
Araki E. , Shimada F. , Fukushima H. , Mori M. , Shichiri M. , Ebina Y.
Diabetes Res. Clin. Pract.7:S31-S33(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33;VARIANT GLY-2
9.

"Characterization of the promoter region and 3' end of the human insulin receptor gene."
Tewari D.S. , Cook D.M. , Taub R.
J. Biol. Chem.264:16238-16245(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33;VARIANT GLY-2
10.

"Structural and functional analysis of the insulin receptor promoter."
McKeon C. , Moncada V. , Pham T. , Salvatore P. , Kadowaki T. , Accili D. , Taylor S.I.
Mol. Endocrinol.4:647-656(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33;VARIANT GLY-2
tissue: Skin fibroblast.
11.

"Substructural analysis of the insulin receptor by microsequence analyses of limited tryptic fragments isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the absence or presence of dithiothreitol."
Xu Q.-Y. , Paxton R.J. , Fujita-Yamaguchi Y.
J. Biol. Chem.265:18673-18681(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-44; 192-205; 299-314; 610-627 AND 763-780;ENZYME REGULATION;SUBUNIT
tissue: Placenta.
12.

"Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification."
Kasuya J. , Paz I.B. , Maddux B.A. , Goldfine I.D. , Hefta S.A. , Fujita-Yamaguchi Y.
Biochemistry32:13531-13536(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-45 AND 763-782;FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH IGF1R
tissue: Placenta.
13.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 538-1382 (ISOFORM SHORT)
tissue: Brain.
14.

"Alternative splicing of human insulin receptor messenger RNA."
Seino S. , Bell G.I.
Biochem. Biophys. Res. Commun.159:312-316(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 728-772 (ISOFORM LONG);ALTERNATIVE SPLICING
15.

"Functionally distinct insulin receptors generated by tissue-specific alternative splicing."
Mosthaf L. , Grako K. , Dull T.J. , Coussens L. , Ullrich A. , McClain D.A.
EMBO J.9:2409-2413(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 744-823 (ISOFORM LONG);TISSUE SPECIFICITY;LIGAND-BINDING;AUTOPHOSPHORYLATION
16.

"Molecular and clinical characterization of an insertional polymorphism of the insulin-receptor gene."
Elbein S.C.
Diabetes38:737-743(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 895-1085
17.

"Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping."
Tavare J.M. , Denton R.M.
Biochem. J.252:607-615(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 927-956; 981-1019; 1182-1194 AND 1352-1369;PHOSPHORYLATION AT TYR-999; TYR-1355 AND TYR-1361
tissue: Placenta.
18.

"Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor."
Taira M. , Taira M. , Hashimoto N. , Shimada F. , Suzuki Y. , Kanatsuka A. , Nakamura F. , Ebina Y. , Tatibana M. , Makino H.
Science245:63-66(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1006-1123
19.

"Partial amino acid sequence analyses of human placental insulin receptor."
Fujita-Yamaguchi Y. , Hawke D. , Shively J.E. , Choi S.
Protein Seq. Data Anal.1:3-6(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
20.

"Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity."
Ebina Y. , Araki E. , Taira M. , Shimada F. , Mori M. , Craik C.S. , Siddle K. , Pierce S.B. , Roth R.A. , Rutter W.J.
Proc. Natl. Acad. Sci. U.S.A.84:704-708(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LYS-1057
21.

"Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity."
White M.F. , Livingston J.N. , Backer J.M. , Lauris V. , Dull T.J. , Ullrich A. , Kahn C.R.
Cell54:641-649(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-999
22.

"Analysis of the order of autophosphorylation of human insulin receptor tyrosines 1158, 1162 and 1163."
Dickens M. , Tavare J.M.
Biochem. Biophys. Res. Commun.186:244-250(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOPHOSPHORYLATION
23.

"Identification of a disulfide bridge connecting the alpha-subunits of the extracellular domain of the insulin receptor."
Schaeffer L. , Ljungqvist L.
Biochem. Biophys. Res. Commun.189:650-653(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;GLYCOSYLATION AT ASN-541
24.

"Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity."
Soos M.A. , Field C.E. , Siddle K.
Biochem. J.290:419-426(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH IGF1R
25.

"Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor."
Van Horn D.J. , Myers M.G. Jr. , Backer J.M.
J. Biol. Chem.269:29-32(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PIK3R1
26.

"Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains."
He W. , O'Neill T.J. , Gustafson T.A.
J. Biol. Chem.270:23258-23262(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRS1 AND SHC1;MUTAGENESIS OF LEU-991; TYR-992; ASN-996; 996-ASN-PRO-997; PRO-997; TYR-999; LEU-1000 AND ALA-1002
27.

"Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain."
Gustafson T.A. , He W. , Craparo A. , Schaub C.D. , O'Neill T.J.
Mol. Cell. Biol.15:2500-2508(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRS1; SHC1 AND PIK3R1;MUTAGENESIS OF ASN-996; PRO-997; GLU-998; TYR-999 AND LYS-1057
28.

"Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting."
Bailyes E.M. , Nave B.T. , Soos M.A. , Orr S.R. , Hayward A.C. , Siddle K.
Biochem. J.327:209-215(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FORMATION OF A HYBRID RECEPTOR WITH IGF1R;TISSUE SPECIFICITY
29.

"Identification of Stat 5B as a substrate of the insulin receptor."
Sawka-Verhelle D. , Filloux C. , Tartare-Deckert S. , Mothe I. , Van Obberghen E.
Eur. J. Biochem.250:411-417(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF STAT5B;MUTAGENESIS OF TYR-999;INTERACTION WITH STAT5B; IRS1 AND IRS2
30.

"Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells."
Ahmad F. , Goldstein B.J.
J. Biol. Chem.272:448-457(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRF
31.

"Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin."
Bandyopadhyay D. , Kusari A. , Kenner K.A. , Liu F. , Chernoff J. , Gustafson T.A. , Kusari J.
J. Biol. Chem.272:1639-1645(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRE;DEPHOSPHORYLATION BY PTPRE
32.

"Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues."
Federici M. , Porzio O. , Zucaro L. , Fusco A. , Borboni P. , Lauro D. , Sesti G.
Mol. Cell. Endocrinol.129:121-126(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FORMATION OF A HYBRID RECEPTOR WITH IGF1R;TISSUE SPECIFICITY
33.

"Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells."
Frasca F. , Pandini G. , Scalia P. , Sciacca L. , Mineo R. , Costantino A. , Goldfine I.D. , Belfiore A. , Vigneri R.
Mol. Cell. Biol.19:3278-3288(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION AS RECEPTOR FOR IGFII (ISOFORM SHORT)
34.

"Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit."
Maddux B.A. , Goldfine I.D.
Diabetes49:13-19(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ENPP1;ENZYME REGULATION
35.

"Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on 'substrate-trapping' mutants."
Waelchli S. , Curchod M.L. , Gobert R.P. , Arkinstall S. , Hooft van Huijsduijnen R.
J. Biol. Chem.275:9792-9796(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN1 AND PTPN2
36.

"Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2."
Kasus-Jacobi A. , Bereziat V. , Perdereau D. , Girard J. , Burnol A.F.
Oncogene19:2052-2059(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB7;MUTAGENESIS OF LYS-1057; TYR-1189 AND TYR-1190
37.

"Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B."
Lin W.-H. , Huang C.-J. , Liu M.-W. , Chang H.-M. , Chen Y.-J. , Tai T.-Y. , Chuang L.-M.
Genomics74:12-20(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SORBS1
38.

"Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain."
Ablooglu A.J. , Frankel M. , Rusinova E. , Ross J.B. , Kohanski R.A.
J. Biol. Chem.276:46933-46940(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;MUTAGENESIS OF ASP-1159 AND ARG-1163;ENZYME REGULATION
39.

"Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14."
Bereziat V. , Kasus-Jacobi A. , Perdereau D. , Cariou B. , Girard J. , Burnol A.F.
J. Biol. Chem.277:4845-4852(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB14;ENZYME REGULATION
40.

"Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved."
Pandini G. , Frasca F. , Mineo R. , Sciacca L. , Vigneri R. , Belfiore A.
J. Biol. Chem.277:39684-39695(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH IGF1R
41.

"Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor."
Wick K.R. , Werner E.D. , Langlais P. , Ramos F.J. , Dong L.Q. , Shoelson S.E. , Liu F.
J. Biol. Chem.278:8460-8467(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB10;ENZYME REGULATION
42.

"Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP."
Galic S. , Klingler-Hoffmann M. , Fodero-Tavoletti M.T. , Puryer M.A. , Meng T.C. , Tonks N.K. , Tiganis T.
Mol. Cell. Biol.23:2096-2108(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN2
43.

"Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans."
Banks A.S. , Li J. , McKeag L. , Hribal M.L. , Kashiwada M. , Accili D. , Rothman P.B.
J. Clin. Invest.115:2462-2471(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOCS7
44.

"Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling."
Fiory F. , Alberobello A.T. , Miele C. , Oriente F. , Esposito I. , Corbo V. , Ruvo M. , Tizzano B. , Rasmussen T.E. , Gammeltoft S. , Formisano P. , Beguinot F.
Mol. Cell. Biol.25:10803-10814(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PDPK1;INTERACTION WITH PDPK1
45.

"Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver."
Nakagawa Y. , Aoki N. , Aoyama K. , Shimizu H. , Shimano H. , Yamada N. , Miyazaki H.
Zool. Sci.22:169-175(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEPHOSPHORYLATION BY PTPRE
46.

"Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant."
Slaaby R. , Schaeffer L. , Lautrup-Larsen I. , Andersen A.S. , Shaw A.C. , Mathiasen I.S. , Brandt J.
J. Biol. Chem.281:25869-25874(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH IGF1R
47.

"Critical nodes in signalling pathways: insights into insulin action."
Taniguchi C.M. , Emanuelli B. , Kahn C.R.
Nat. Rev. Mol. Cell Biol.7:85-96(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON SIGNALING PATHWAYS
48.

"Regulation of insulin receptor function."
Youngren J.F.
Cell. Mol. Life Sci.64:873-891(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON REGULATION OF INSR FUNCTION
49.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400; TYR-401 AND SER-407;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
50.

"A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides."
Menting J.G. , Ward C.W. , Margetts M.B. , Lawrence M.C.
Biochemistry48:5492-5500(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;INSULIN-BINDING SITE
51.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-242 AND ASN-541
tissue: Liver.
52.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
53.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-445 AND ASN-920
tissue: Leukemic T-cell.
54.

"Crystal structure of the tyrosine kinase domain of the human insulin receptor."
Hubbard S.R. , Wei L. , Ellis L. , Hendrickson W.A.
Nature372:746-754(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1005-1310
55.

"Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog."
Hubbard S.R.
EMBO J.16:5572-5581(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 1005-1310 IN COMPLEX WITH ATP ANALOG AND IRS1 PEPTIDE;CATALYTIC ACTIVITY;ACTIVE SITE;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-1185; TYR-1189 AND TYR-1190
56.

"Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism."
Till J.H. , Ablooglu A.J. , Frankel M. , Bishop S.M. , Kohanski R.A. , Hubbard S.R.
J. Biol. Chem.276:10049-10055(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 1005-1310 IN COMPLEX WITH ATP ANALOG;CATALYTIC ACTIVITY
57.

"Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor."
Li S. , Covino N.D. , Stein E.G. , Till J.H. , Hubbard S.R.
J. Biol. Chem.278:26007-26014(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 1005-1298 OF MUTANT ASN-1159;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;MUTAGENESIS OF TYR-1011
58.

"Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor."
Hu J. , Liu J. , Ghirlando R. , Saltiel A.R. , Hubbard S.R.
Mol. Cell12:1379-1389(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1005-1310 IN COMPLEX WITH ATP ANALOG AND SH2B2;PHOSPHORYLATION AT TYR-1185; TYR-1189 AND TYR-1190
59.

"Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14."
Depetris R.S. , Hu J. , Gimpelevich I. , Holt L.J. , Daly R.J. , Hubbard S.R.
Mol. Cell20:325-333(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 1005-1310 IN COMPLEX WITH GRB14;INTERACTION WITH GRB14;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-1185; TYR-1189 AND TYR-1190
60.

"Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase."
Li S. , Depetris R.S. , Barford D. , Chernoff J. , Hubbard S.R.
Structure13:1643-1651(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1005-1310 IN COMPLEX WITH PTPN1;PHOSPHORYLATION AT TYR-1185; TYR-1189 AND TYR-1190
61.

"Structure of the insulin receptor ectodomain reveals a folded-over conformation."
McKern N.M. , Lawrence M.C. , Streltsov V.A. , Lou M.Z. , Adams T.E. , Lovrecz G.O. , Elleman T.C. , Richards K.M. , Bentley J.D. , Pilling P.A. , Hoyne P.A. , Cartledge K.A. , Pham T.M. , Lewis J.L. , Sankovich S.E. , Stoichevska V. , Da Silva E. , Robinson C.P. , more...
Nature443:218-221(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF 28-943 IN COMPLEX WITH INSULIN ANALOG;DOMAIN;DISULFIDE BONDS
62.

"The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity."
Lou M. , Garrett T.P. , McKern N.M. , Hoyne P.A. , Epa V.C. , Bentley J.D. , Lovrecz G.O. , Cosgrove L.J. , Frenkel M.J. , Ward C.W.
Proc. Natl. Acad. Sci. U.S.A.103:12429-12434(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) OF 28-512;GLYCOSYLATION AT ASN-43; ASN-52; ASN-138; ASN-242; ASN-282; ASN-364; ASN-424 AND ASN-445;DISULFIDE BONDS
63.

"Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2."
Wu J. , Tseng Y.D. , Xu C.F. , Neubert T.A. , White M.F. , Hubbard S.R.
Nat. Struct. Mol. Biol.15:251-258(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 1005-1310 IN COMPLEX WITH ATP AND IRS2;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-1185; TYR-1189 AND TYR-1190;INTERACTION WITH IRS2
64.

"Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors."
Katayama N. , Orita M. , Yamaguchi T. , Hisamichi H. , Kuromitsu S. , Kurihara H. , Sakashita H. , Matsumoto Y. , Fujita S. , Niimi T.
Proteins73:795-801(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 1009-1310 IN COMPLEX WITH INHIBITORY PEPTIDE;PHOSPHORYLATION AT TYR-1185; TYR-1189 AND TYR-1190
65.

"Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity."
Chamberlain S.D. , Redman A.M. , Wilson J.W. , Deanda F. , Shotwell J.B. , Gerding R. , Lei H. , Yang B. , Stevens K.L. , Hassell A.M. , Shewchuk L.M. , Leesnitzer M.A. , Smith J.L. , Sabbatini P. , Atkins C. , Groy A. , Rowand J.L. , Kumar R. , more...
Bioorg. Med. Chem. Lett.19:360-364(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 1005-1310 IN COMPLEX WITH SYNTHETIC INHIBITOR;CATALYTIC ACTIVITY
66.

"Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase."
Chamberlain S.D. , Wilson J.W. , Deanda F. , Patnaik S. , Redman A.M. , Yang B. , Shewchuk L. , Sabbatini P. , Leesnitzer M.A. , Groy A. , Atkins C. , Gerding R. , Hassell A.M. , Lei H. , Mook R.A. Jr. , Moorthy G. , Rowand J.L. , Stevens K.L. , more...
Bioorg. Med. Chem. Lett.19:469-473(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1005-1310 IN COMPLEX WITH SYNTHETIC INHIBITOR;CATALYTIC ACTIVITY
67.

"Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase."
Patnaik S. , Stevens K.L. , Gerding R. , Deanda F. , Shotwell J.B. , Tang J. , Hamajima T. , Nakamura H. , Leesnitzer M.A. , Hassell A.M. , Shewchuck L.M. , Kumar R. , Lei H. , Chamberlain S.D.
Bioorg. Med. Chem. Lett.19:3136-3140(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 1017-1322 IN COMPLEX WITH SYNTHETIC INHIBITOR;CATALYTIC ACTIVITY
68.

"Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists."
Smith B.J. , Huang K. , Kong G. , Chan S.J. , Nakagawa S. , Menting J.G. , Hu S.Q. , Whittaker J. , Steiner D.F. , Katsoyannis P.G. , Ward C.W. , Weiss M.A. , Lawrence M.C.
Proc. Natl. Acad. Sci. U.S.A.107:6771-6776(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.80 ANGSTROMS) OF 28-956;INSULIN-BINDING REGION;DISULFIDE BONDS
69.

"How insulin engages its primary binding site on the insulin receptor."
Menting J.G. , Whittaker J. , Margetts M.B. , Whittaker L.J. , Kong G.K. , Smith B.J. , Watson C.J. , Zakova L. , Kletvikova E. , Jiracek J. , Chan S.J. , Steiner D.F. , Dodson G.G. , Brzozowski A.M. , Weiss M.A. , Ward C.W. , Lawrence M.C.
Nature493:241-245(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.9 ANGSTROMS) OF 28-620 IN COMPLEX WITH INSULIN;DOMAIN;GLYCOSYLATION AT ASN-43; ASN-52; ASN-138; ASN-242 AND ASN-282;DISULFIDE BONDS
70.

"Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing."
Yoshimasa Y. , Seino S. , Whittaker J. , Kakehi T. , Kosaki A. , Kuzuya H. , Imura H. , Bell G.I. , Steiner D.F.
Science240:784-787(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A SER-762
71.

"Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance."
Kadowaki T. , Bevins C. , Cama A. , Ojamaa K. , Marcus-Samuels B. , Kadowaki H. , Beitz L. , McKeon C. , Taylor S.I.
Science240:787-790(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH GLU-487
72.

"A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance."
Klinkhamer M.P. , Groen N.A. , van der Zon G.C.M. , Lindhout D. , Sandkuyl L.A. , Krans H.M.J. , Moeller W. , Maassen J.A.
EMBO J.8:2503-2507(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH PRO-260
73.

"Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor."
Odawara M. , Kadowaki T. , Yamamoto R. , Shibasaki Y. , Tobe K. , Accili D. , Bevins C. , Mikami Y. , Matsuura N. , Akanuma Y. , Takaku F. , Taylor S.I. , Kasuga M.
Science245:66-68(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A VAL-1035
74.

"A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance."
Moller D.E. , Yokota A. , White M.F. , Pazianos A.G. , Flier J.S.
J. Biol. Chem.265:14979-14985(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A THR-1161
75.

"Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding."
Kadowaki T. , Kadowaki H. , Accili D. , Taylor S.I.
J. Biol. Chem.265:19143-19150(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT RMS LYS-42
76.

"Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance."
Kadowaki T. , Kadowaki H. , Rechler M.M. , Serrano-Rios M. , Roth J. , Gorden P. , Taylor S.I.
J. Clin. Invest.86:254-264(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT RMS LYS-42;VARIANT LEPRCH ARG-236;VARIANT IRAN TYPE A SER-489
77.

"Functional properties of a naturally occurring Trp1200-->Ser1200 mutation of the insulin receptor."
Moller D.E. , Yokota A. , Ginsberg-Fellner F. , Flier J.S.
Mol. Endocrinol.4:1183-1191(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A SER-1227
78.

"Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms."
O'Rahilly S. , Choi W.H. , Patel P. , Turner R.C. , Flier J.S. , Moller D.E.
Diabetes40:777-782(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLU-1095
79.

"Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles."
Kusari J. , Takata Y. , Hatada E. , Freidenberg G. , Kolterman O. , Olefsky J.M.
J. Biol. Chem.266:5260-5267(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A GLN-1020
80.

"A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman."
Cama A. , de la Luz Sierra M. , Ottini L. , Kadowaki T. , Gorden P. , Imperato-Mcginley J. , Taylor S.I.
J. Clin. Endocrinol. Metab.73:894-901(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT INS RESISTANCE ILE-1180
81.

"Detection of mutations in insulin receptor gene by denaturing gradient gel electrophoresis."
Barbetti F. , Gejman P.V. , Taylor S.I. , Raben N. , Cama A. , Bonora E. , Pizzo P. , Moghetti P. , Muggeo M. , Roth J.
Diabetes41:408-415(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEPRCH ALA-55 AND ARG-393
82.

"NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene."
Cocozza S. , Porcellini A. , Riccardi G. , Monticelli A. , Condorelli G. , Ferrara A. , Pianese L. , Miele C. , Capaldo B. , Beguinot F. , Varrone S.
Diabetes41:521-526(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NIDDM GLN-1191
83.

"Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms."
Kim H. , Kadowaki H. , Sakura H. , Odawara M. , Momomura K. , Takahashi Y. , Miyazaki Y. , Ohtani T. , Akanuma Y. , Yazaki Y. , Kasuga M. , Taylor S.I. , Kadowaki T.
Diabetologia35:261-266(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A LEU-1205
84.

"An Arg for Gly substitution at position 31 in the insulin receptor, linked to insulin resistance, inhibits receptor processing and transport."
van der Vorm E.R. , van der Zon G.C.M. , Moeller W. , Krans H.M.J. , Lindhout D. , Maassen J.A.
J. Biol. Chem.267:66-71(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH ARG-58
85.

"Insulin receptor Arg1131-->Gln: a novel mutation in the catalytic loop of insulin receptor observed in insulin resistant diabetes."
Kasuga M. , Kishimoto M. , Hashiramoto M. , Yonezawa K. , Kazumi T. , Hagino H. , Shii K.
Nihon Geka Gakkai Zasshi93:968-971(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NIDDM GLN-1158
86.

"Methionine for valine substitution in exon 17 of the insulin receptor gene in a pedigree with familial NIDDM."
Elbein S.C. , Sorensen L.K. , Schumacher M.C.
Diabetes42:429-434(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-1012
87.

"Ala1048-->Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance."
Haruta T. , Takata Y. , Iwanishi M. , Maegawa H. , Imamura T. , Egawa K. , Itazu T. , Kobayashi M.
Diabetes42:1837-1844(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A ASP-1075
88.

"Patients with lipodystrophic diabetes mellitus of the Seip-Berardinelli type, express normal insulin receptors."
van der Vorm E.R. , Kuipers A. , Bonenkamp J.W. , Kleijer W.J. , van Maldergem L. , Herwig J. , Maassen J.A.
Diabetologia36:172-174(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-1012
89.

"A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance."
Iwanishi M. , Haruta T. , Takata Y. , Ishibashi O. , Sasaoka T. , Egawa K. , Imamura T. , Naitou K. , Itazu T. , Kobayashi M.
Diabetologia36:414-422(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT INS RESISTANCE LEU-1220
90.

"Substitution of Leu for Pro-193 in the insulin receptor in a patient with a genetic form of severe insulin resistance."
Carrera P. , Cordera R. , Ferrari M. , Cremonesi L. , Taramelli R. , Andraghetti G. , Carducci C. , Dozio N. , Pozza G. , Taylor S.I. , Micossi P. , Barbetti F.
Hum. Mol. Genet.2:1437-1441(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT INS RESISTANCE LEU-220
91.

"Substitution of glutamic acid for alanine 1135 in the putative 'catalytic loop' of the tyrosine kinase domain of the human insulin receptor. A mutation that impairs proteolytic processing into subunits and inhibits receptor tyrosine kinase activity."
Cama A. , de la Luz Sierra M. , Quon M.J. , Ottini L. , Gorden P. , Taylor S.I.
J. Biol. Chem.268:8060-8069(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT IRAN TYPE A GLU-1162
92.

"Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382."
Lebrun C. , Baron V. , Kaliman P. , Gautier N. , Dolais-Kitabgi J. , Taylor S.I. , Accili D. , van Obberghen E.
J. Biol. Chem.268:11272-11277(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A VAL-409
93.

"A syndrome of insulin resistance resembling leprechaunism in five sibs of consanguineous parents."
Al-Gazali L.I. , Khalil M. , Devadas K.
J. Med. Genet.30:470-475(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH MET-146
94.

"Activation of glucose transport by a natural mutation in the human insulin receptor."
Longo N. , Langley S.D. , Griffin L.D. , Elsas L.J.
Proc. Natl. Acad. Sci. U.S.A.90:60-64(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH PRO-113
95.

"Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance."
Moller D.E. , Cohen O. , Yamaguchi Y. , Assiz R. , Grigorescu F. , Eberle A. , Morrow L.A. , Moses A.C. , Flier J.S.
Diabetes43:247-255(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A GLN-1201
96.

"Molecular scanning of the insulin receptor gene in syndromes of insulin resistance."
Krook A. , Kumar S. , Laing I. , Boulton A.J. , Wass J.A. , O'Rahilly S.
Diabetes43:357-368(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT RMS SYNDROME LEU-350;VARIANTS IRAN TYPE A LEU-1205 AND GLN-1378;VARIANT MET-1012
97.

"Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient."
Moritz W. , Froesch E.R. , Boeni-Schnetzler M.
FEBS Lett.351:276-280(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT IRAN TYPE A GLN-1201
98.

"A mutation in the insulin receptor that impairs proreceptor processing but not insulin binding."
van der Vorm E.R. , Kuipers A. , Kielkopf-Renner S. , Krans H.M.J. , Moller W. , Maassen J.A.
J. Biol. Chem.269:14297-14302(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH SER-439
99.

"Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity."
Imamura T. , Takata Y. , Sasaoka T. , Takada Y. , Morioka H. , Haruta T. , Sawa T. , Iwanishi M. , Hu Y.G. , Suzuki Y. , Hamada J. , Kobayashi M.
J. Biol. Chem.269:31019-31027(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS IRAN TYPE A ASP-1206 AND LEU-1220
100.

"Homozygosity for a new mutation (Ile119-->Met) in the insulin receptor gene in five sibs with familial insulin resistance."
Hone J. , Accili D. , al-Gazali L.I. , Lestringant G. , Orban T. , Taylor S.I.
J. Med. Genet.31:715-716(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH MET-146
101.

"Frequency of mutations of insulin receptor gene in Japanese patients with NIDDM."
Kan M. , Kanai F. , Iida M. , Jinnouchi H. , Todaka M. , Imanaka T. , Ito K. , Nishioka Y. , Ohnishi T. , Kamohara S. , Hayashi H. , Murakami T. , Kagawa S. , Sano H. , Hashimoto N. , Yoshida S. , Makino H. , Ebina Y.
Diabetes44:1081-1086(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NIDDM ALA-858;VARIANT CYS-1361
102.

"Two mutations in the insulin receptor gene of a patient with leprechaunism: application to prenatal diagnosis."
Longo N. , Langley S.D. , Griffin L.D. , Elsas L.J.
J. Clin. Endocrinol. Metab.80:1496-1501(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH ASN-308 DEL
103.

"In-frame exon 2 deletion in insulin receptor RNA in a family with extreme insulin resistance in association with defective insulin binding: a case report."
Moritz W. , Boeni-Schnetzler M. , Stevens W. , Froesch E.R. , Levy J.R.
Eur. J. Endocrinol.135:357-363(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PHE-1023
104.

"Deletion of Asn281 in the alpha-subunit of the human insulin receptor causes constitutive activation of the receptor and insulin desensitization."
Desbois-Mouthon C. , Sert-Langeron C. , Magre J. , Oreal E. , Blivet M.J. , Flori E. , Besmond C. , Capeau J. , Caron M.
J. Clin. Endocrinol. Metab.81:719-727(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH ASN-308 DEL
105.

"The Val985Met insulin-receptor variant in the Danish Caucasian population: lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance."
Hansen L. , Hansen T. , Clausen J.O. , Echwald S.M. , Urhammer S.A. , Rasmussen S.K. , Pedersen O.
Am. J. Hum. Genet.60:1532-1535(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-1012
106.

"Identification of two novel insulin receptor mutations, Asp59Gly and Leu62Pro, in type A syndrome of extreme insulin resistance."
Rouard M. , Macari F. , Bouix O. , Lautier C. , Brun J.F. , Lefebvre P. , Renard E. , Bringer J. , Jaffiol C. , Grigorescu F.
Biochem. Biophys. Res. Commun.234:764-768(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IRAN TYPE A GLY-86 AND PRO-89
107.

"Four mutant alleles of the insulin receptor gene associated with genetic syndromes of extreme insulin resistance."
Kadowaki H. , Takahashi Y. , Ando A. , Momomura K. , Kaburagi Y. , Quin J.D. , MacCuish A.C. , Koda N. , Fukushima Y. , Taylor S.I. , Akanuma Y. , Yazaki Y. , Kadowaki T.
Biochem. Biophys. Res. Commun.237:516-520(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT LEPRCH MET-937
108.

"Molecular analysis of the insulin receptor gene for prenatal diagnosis of leprechaunism in two families."
Desbois-Mouthon C. , Girodon E. , Ghanem N. , Caron M. , Pennerath A. , Conteville P. , Magre J. , Besmond C. , Goossens M. , Capeau J. , Amselem S.
Prenat. Diagn.17:657-663(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEPRCH TRP-1119 AND LYS-1206
109.

"Multiple molecular mechanisms of insulin receptor dysfunction in a patient with Donohue syndrome."
Whitehead J.P. , Soos M.A. , Jackson R. , Tasic V. , Kocova M. , O'Rahilly S.
Diabetes47:1362-1364(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEPRCH TYR-301 AND TRP-1201
110.

"Progressive decline in insulin levels in Rabson-Mendenhall syndrome."
Longo N. , Wang Y. , Pasquali M.
J. Clin. Endocrinol. Metab.84:2623-2629(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS RMS THR-1143 AND TRP-1158
111.

"Identification of three novel mutations in the insulin receptor gene in type A insulin resistant patients."
Rique S. , Nogues C. , Ibanez L. , Marcos M.V. , Ferragut J. , Carrascosa A. , Potau N.
Clin. Genet.57:67-69(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IRAN TYPE A LEU-167 AND VAL-1055
112.

"Identification of novel C253Y missense and Y864X nonsense mutations in the insulin receptor gene in type A insulin-resistant patients."
Osawa H. , Nishimiya T. , Ochi M. , Niiya T. , Onuma H. , Kitamuro F. , Kaino Y. , Kida K. , Makino H.
Clin. Genet.59:194-197(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A TYR-280
113.

"An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events."
Hamer I. , Foti M. , Emkey R. , Cordier-Bussat M. , Philippe J. , De Meyts P. , Maeder C. , Kahn C.R. , Carpentier J.-L.
Diabetologia45:657-667(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A CYS-279
114.

"Genotype-phenotype correlation in inherited severe insulin resistance."
Longo N. , Wang Y. , Smith S.A. , Langley S.D. , DiMeglio L.A. , Giannella-Neto D.
Hum. Mol. Genet.11:1465-1475(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS LEPRCH PRO-113; VAL-119; ASN-308 DEL; THR-925 AND TRP-926;VARIANTS RMS THR-997; THR-1143; TRP-1158 AND TRP-1201
115.

"Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject."
George S. , Johansen A. , Soos M.A. , Mortensen H. , Gammeltoft S. , Saudek V. , Siddle K. , Hansen L. , O'Rahilly S.
Endocrinology144:631-637(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEPRCH VAL-362 DEL
116.

"Identification and functional assessment of novel and known insulin receptor mutations in five patients with syndromes of severe insulin resistance."
Maassen J.A. , Tobias E.S. , Kayserilli H. , Tukel T. , Yuksel-Apak M. , D'Haens E. , Kleijer W.J. , Fery F. , van der Zon G.C.M.
J. Clin. Endocrinol. Metab.88:4251-4257(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRAN TYPE A HIS-279;VARIANTS LEPRCH GLN-120; LEU-350; ASP-458 AND TRP-1119;CHARACTERIZATION OF VARIANT IRAN TYPE A HIS-279;CHARACTERIZATION OF VARIANTS LEPRCH GLN-120 AND ASP-458
117.

"A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene."
Hoejlund K. , Hansen T. , Lajer M. , Henriksen J.E. , Levin K. , Lindholm J. , Pedersen O. , Bech-Nielsen H.
Diabetes53:1592-1598(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HHF5 GLN-1201
118.

"Functional characterization of a novel insulin receptor mutation contributing to Rabson-Mendenhall syndrome."
Tuthill A. , Semple R.K. , Day R. , Soos M.A. , Sweeney E. , Seymour P.J. , Didi M. , O'Rahilly S.
Clin. Endocrinol. (Oxf.)66:21-26(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS RMS ARG-236 AND SER-386;CHARACTERIZATION OF VARIANTS RMS ARG-236 AND SER-386
119.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-228; ARG-695; SER-811; MET-1012; VAL-1065 AND ALA-1282

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