Insr ELISA Kit for Mouse(Mus musculus) | EIAab.comInsr ELISA Kit for Mouse(Mus musculus)

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Insr (Gene name),

Insulin receptor (Protein name ), INSR_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Insr;

Protein name:

Insulin receptor(IR);

Alternative:

CD:

CD220;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Interacts with SORBS1 but dissociates from it following insulin stimulation. Binds SH2B2. Interacts with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. The sequences surrounding the phosphorylated NPXY motif contribute differentially to either IRS1 or SHC1 recognition. Interacts with the SH2 domains of the 85 kDa regulatory subunit of PI3K (PIK3R1) in vitro, when autophosphorylated on tyrosine residues. Interacts with SOCS7. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with CAV2 (tyrosine-phosphorylated form); the interaction is increased with 'Tyr-27'phosphorylation of CAV2 (By similarity). Interacts with ARRB2. Interacts with GRB10; this interaction blocks the association between IRS1/IRS2 and INSR, significantly reduces insulin-stimulated tyrosine phosphorylation of IRS1 and IRS2 and thus decreases insulin signaling. Interacts with GRB7.

Function:

This receptor binds insulin and has a tyrosine-protein kinase activity. When present in a hybrid receptor with IGF1R, binds IGF1.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1372

Sequence:

50:

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1150:

1200:

1250:

1300:

1350:

1372:

YTHMNGGKKN | GRVLTLPRSN | PS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P15208

Pfam:

PF00041

SMR:

P15208

KEGG:

mmu:16337

UniGene:

Mm.268003

Uniprot:

P15208

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ELISA Kit for Mouse IR

Cat.:

E0895h

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96T

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ELISA Kit for Mouse IR

Cat.:

E0895m

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96T

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ELISA Kit for Mouse IR

Cat.:

E0895r

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96T

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CLIA Kit for Mouse IR

Cat.:

U0895m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse IR

Cat.:

U0895h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse IR

Cat.:

U0895r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse IR

Cat.:

P0895Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse IR

Cat.:

P0895Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse IR

Cat.:

P0895Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse IR

Protein for Mouse IR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit."
Flores-Riveros J.R. , Sibley E. , Kastelic T. , Lane M.D.
J. Biol. Chem.264:21557-21572(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"Characterization of the mouse insulin receptor gene promoter."
Sibley E. , Kastelic T. , Kelly T.J. , Lane M.D.
Proc. Natl. Acad. Sci. U.S.A.86:9732-9736(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33
4.

"Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786."
Sawka-Verhelle D. , Tartare-Deckert S. , White M.F. , Van Obberghen E.
J. Biol. Chem.271:5980-5983(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRS1 AND IRS2;MUTAGENESIS OF TYR-989
5.

"A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes."
Ribon V. , Printen J.A. , Hoffman N.G. , Kay B.K. , Saltiel A.R.
Mol. Cell. Biol.18:872-879(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SORBS1
6.

"Mutation of tyrosine 960 within the insulin receptor juxtamembrane domain impairs glucose transport but does not inhibit ligand-mediated phosphorylation of insulin receptor substrate-2 in 3T3-L1 adipocytes."
Chaika O.V. , Chaika N. , Volle D.J. , Hayashi H. , Ebina Y. , Wang L.M. , Pierce J.H. , Lewis R.E.
J. Biol. Chem.274:12075-12080(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-989
7.

"SOCS-3 is an insulin-induced negative regulator of insulin signaling."
Emanuelli B. , Peraldi P. , Filloux C. , Sawka-Verhelle D. , Hilton D. , Van Obberghen E.
J. Biol. Chem.275:15985-15991(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOCS3
8.

"Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP."
Galic S. , Klingler-Hoffmann M. , Fodero-Tavoletti M.T. , Puryer M.A. , Meng T.C. , Tonks N.K. , Tiganis T.
Mol. Cell. Biol.23:2096-2108(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN2
9.

"Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms."
Ueki K. , Kondo T. , Kahn C.R.
Mol. Cell. Biol.24:5434-5446(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOCS1 AND SOCS3
10.

"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-445
tissue: Myoblast.
11.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-445
12.

"Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance."
Luan B. , Zhao J. , Wu H. , Duan B. , Shu G. , Wang X. , Li D. , Jia W. , Kang J. , Pei G.
Nature457:1146-1149(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2

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