Protein name:
Insulin ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subcellular Location:
Secreted
Protein Attributes:
50:
MALWMRLLPL | LALLALWGPD | PAAAFVNQHL | CGSHLVEALY | LVCGERGFFY |
100:
TPKTRREAED | LQVGQVELGG | GPGAGSLQPL | ALEGSLQKRG | IVEQCCTSIC |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Dog
Chicken
Human
Pig
Rabbit
Mouse
Rat
ELISA Kit for Human Insulin
ELISA Kit for Human Insulin
ELISA Kit for Human Insulin
ELISA Kit for Human Insulin
ELISA Kit for Human Insulin
ELISA Kit for Human Insulin
ELISA Kit for Human Insulin
ELISA Kit for Human Insulin
CLIA Kit for Human Insulin
CLIA Kit for Human Insulin
CLIA Kit for Human Insulin
CLIA Kit for Human Insulin
CLIA Kit for Human Insulin
CLIA Kit for Human Insulin
CLIA Kit for Human Insulin
CLIA Kit for Human Insulin
Polyclonal Antibody for Human Insulin
Polyclonal Antibody for Human Insulin
Polyclonal Antibody for Human Insulin
Polyclonal Antibody for Human Insulin
Polyclonal Antibody for Human Insulin
Polyclonal Antibody for Human Insulin
Polyclonal Antibody for Human Insulin
Polyclonal Antibody for Human Insulin
Monoclonal Antibody for Human Insulin
Monoclonal Antibody for Human Insulin
Monoclonal Antibody for Human Insulin
Monoclonal Antibody for Human Insulin
Monoclonal Antibody for Human Insulin
Monoclonal Antibody for Human Insulin
Monoclonal Antibody for Human Insulin
Monoclonal Antibody for Human Insulin
Protein for Human Insulin
Protein for Human Insulin
Protein for Human Insulin
Protein for Human Insulin
Protein for Human Insulin
Protein for Human Insulin
Protein for Human Insulin
Protein for Human Insulin
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Jing-Jie Tang, Jia-Gui Li, Wei Qi, Wen-Wei Qiu, Pei-Shan Li, Bo-Liang Li, Bao-Liang Song
[2].
BW Liu, Q Lu, CM Ma, et al.
[3].
R Wang, Q Lu, J Feng, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
,
Chen X.
,
Rolfs A.
,
Halleck A.
,
Hines L.
,
Eisenstein S.
,
Koundinya M.
,
Raphael J.
,
Moreira D.
,
Kelley T.
,
LaBaer J.
,
Lin Y.
,
Phelan M.
,
Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
9.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Pancreas .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59
tissue :
Blood .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 25-54 AND 90-110
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 57-87
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 57-87
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SYNTHESIS
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SYNTHESIS OF 57-87
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SYNTHESIS OF 65-69 AND 70-73
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SYNTHESIS OF 84-87
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LOS ANGELES SER-48
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS LOS ANGELES SER-48 AND CHICAGO LEU-49
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FHPRI ASP-34
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT WAKAYAMA LEU-92
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FHPRI HIS-89
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FHPRI HIS-89
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FHPRI LEU-89
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF VARIANT LOS-ANGELES SER-48
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR
32.
"Insulin gene mutations as a cause of permanent neonatal diabetes."
Stoy J.
,
Edghill E.L.
,
Flanagan S.E.
,
Ye H.
,
Paz V.P.
,
Pluzhnikov A.
,
Below J.E.
,
Hayes M.G.
,
Cox N.J.
,
Lipkind G.M.
,
Lipton R.B.
,
Greeley S.A.
,
Patch A.M.
,
Ellard S.
,
Steiner D.F.
,
Hattersley A.T.
,
Philipson L.H.
,
Bell G.I.
Proc. Natl. Acad. Sci. U.S.A.104:15040-15044(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PNDM ASP-24; ARG-32; SER-32; GLY-43; VAL-47; CYS-48; CYS-89; CYS-90; TYR-96 AND CYS-108
33.
"Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood."
Edghill E.L.
,
Flanagan S.E.
,
Patch A.M.
,
Boustred C.
,
Parrish A.
,
Shields B.
,
Shepherd M.H.
,
Hussain K.
,
Kapoor R.R.
,
Malecki M.
,
MacDonald M.J.
,
Stoy J.
,
Steiner D.F.
,
Philipson L.H.
,
Bell G.I.
,
Hattersley A.T.
,
Ellard S.
Diabetes57:1034-1042(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PNDM ASP-24; ASP-29; ARG-32; SER-32; PRO-35; GLY-43; VAL-47; CYS-48; ARG-84; CYS-89; CYS-90; SER-96; TYR-96; CYS-101; CYS-103 AND CYS-108;VARIANT MODY10 CYS-6;VARIANT MET-68
34.
"Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes."
Molven A.
,
Ringdal M.
,
Nordbo A.M.
,
Raeder H.
,
Stoy J.
,
Lipkind G.M.
,
Steiner D.F.
,
Philipson L.H.
,
Bergmann I.
,
Aarskog D.
,
Undlien D.E.
,
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[
PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT MODY10 GLN-46;VARIANT IDDM2 CYS-55
35.
"Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)."
Boesgaard T.W.
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Pruhova S.
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Andersson E.A.
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Cinek O.
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BMC Med. Genet.11:42-42(2010)
[
PubMed ]
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Europe PMC ]
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Abstract ]
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Cited for : VARIANTS MODY10 HIS-6 AND GLN-46