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Index > Protein center > INS(Gene name) > Human
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  • INS (Gene name),
  • Insulin (Protein name ),  INS_HUMAN from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
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  • Predicted Eptitope
  • |
  • Vaild Sequence
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  • Related Databases
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  • Citations  (3)
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  • Gene name:
    INS;
    Protein name:
    Insulin;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of a B chain and an A chain linked by two disulfide bonds.
    Function:
    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    110
    Sequence:
    50:
    MALWMRLLPL | LALLALWGPD | PAAAFVNQHL | CGSHLVEALY | LVCGERGFFY | 
    100:
    TPKTRREAED | LQVGQVELGG | GPGAGSLQPL | ALEGSLQKRG | IVEQCCTSIC | 
    110:
    SLYQLENYCN | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    SMR:
    KEGG:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Insulin
    Cat.:
    E0448b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Insulin
    Cat.:
    E0448d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Insulin
    Cat.:
    E0448c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Insulin
    Cat.:
    E0448h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Insulin
    Cat.:
    E0448p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Insulin
    MSDS:
    Please sign in first.
    ELISA Kit for Human Insulin
    Cat.:
    E0448m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Insulin
    Cat.:
    E0448r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Insulin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Insulin
    Cat.:
    U0448m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Insulin
    Cat.:
    U0448r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Insulin
    Cat.:
    U0448h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Insulin
    Cat.:
    U0448c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Insulin
    Cat.:
    U0448d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Insulin
    Cat.:
    U0448p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Insulin
    Cat.:
    U0448b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Insulin
    Polyclonal Antibody for Human Insulin
    Polyclonal Antibody for Human Insulin
    Polyclonal Antibody for Human Insulin
    Cat.:
    P0448Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Insulin
    Cat.:
    P0448Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Insulin
    Polyclonal Antibody for Human Insulin
    Polyclonal Antibody for Human Insulin
    Cat.:
    P0448Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Insulin
    Monoclonal Antibody for Human Insulin
    Monoclonal Antibody for Human Insulin
    Monoclonal Antibody for Human Insulin
    Cat.:
    M0448h
    Price:
    Please sign in first.
    Packing:
    40ug
    Monoclonal Antibody for Human Insulin
    Monoclonal Antibody for Human Insulin
    Monoclonal Antibody for Human Insulin
    Monoclonal Antibody for Human Insulin
    Protein for Human Insulin
    Protein for Human Insulin
    Protein for Human Insulin
    Protein for Human Insulin
    Protein for Human Insulin
    Cat.:
    R0448h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Insulin
    Protein for Human Insulin
    Protein for Human Insulin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Genetic variation in the human insulin gene."
      Ullrich A. , Dull T.J. , Gray A. , Brosius J. , Sures I.
      Science209:612-615(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Nucleotide sequence of a cDNA clone encoding human preproinsulin."
      Bell G.I. , Swain W.F. , Pictet R.L. , Cordell B. , Goodman H.M. , Rutter W.J.
      Nature282:525-527(1979) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Nucleotide sequence of human preproinsulin complementary DNA."
      Sures I. , Goeddel D.V. , Gray A. , Ullrich A.
      Science208:57-59(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR."
      Lucassen A.M. , Julier C. , Beressi J.-P. , Boitard C. , Froguel P. , Lathrop M. , Bell J.I.
      Nat. Genet.4:305-310(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Insulinomas and expression of an insulin splice variant."
      Minn A.H. , Kayton M. , Lorang D. , Hoffmann S.C. , Harlan D.M. , Libutti S.K. , Shalev A.
      Lancet363:363-367(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    7. 7.
      "Global haplotype diversity in the human insulin gene region."
      Stead J.D.H. , Hurles M.E. , Jeffreys A.J.
      Genome Res.13:2101-2111(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    8. 8.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pancreas.
    11. 11.
      "Description of a novel RFLP diallelic polymorphism (-127 BsgI C/G) within the 5' region of insulin gene."
      Fajardy I.I. , Weill J.J. , Stuckens C.C. , Danze P.M.P.
      Submitted (1998-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59
      tissue: Blood.
    12. 12.
      "Amino-acid sequence of human insulin."
      Nicol D.S.H.W. , Smith L.F.
      Nature187:483-485(1960) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-54 AND 90-110
    13. 13.
      "Studies on human proinsulin. Isolation and amino acid sequence of the human pancreatic C-peptide."
      Oyer P.E. , Cho S. , Peterson J.D. , Steiner D.F.
      J. Biol. Chem.246:1375-1386(1971) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 57-87
    14. 14.
      "The amino acid sequence of the C-peptide of human proinsulin."
      Ko A. , Smyth D.G. , Markussen J. , Sundby F.
      Eur. J. Biochem.20:190-199(1971) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 57-87
    15. 15.
      "Total synthesis of human insulin under directed formation of the disulfide bonds."
      Sieber P. , Kamber B. , Hartmann A. , Joehl A. , Riniker B. , Rittel W.
      Helv. Chim. Acta57:2617-2621(1974) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS
    16. 16.
      "Studies on polypeptides, IV. The synthesis of C-peptide of human proinsulin."
      Naithani V.K.
      Hoppe-Seyler's Z. Physiol. Chem.354:659-672(1973) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF 57-87
    17. 17.
      "Synthesis of peptides with the properties of human proinsulin C peptides (hC peptide). 3. Synthesis of the sequences 14-17 and 9-13 of human proinsulin C peptides."
      Geiger R. , Volk A.
      Chem. Ber.106:199-205(1973) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF 65-69 AND 70-73
    18. 18.
      "Synthesis of peptides with the properties of human proinsulin C peptides (hC peptide). I. Scheme for the synthesis and preparation of the sequence 28-31 of human proinsulin C peptide."
      Geiger R. , Jaeger G. , Keonig W. , Treuth G.
      Chem. Ber.106:188-192(1973) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF 84-87
    19. 19.
      "Studies on mutant human insulin genes: identification and sequence analysis of a gene encoding [SerB24]insulin."
      Haneda M. , Chan S.J. , Kwok S.C.M. , Rubenstein A.H. , Steiner D.F.
      Proc. Natl. Acad. Sci. U.S.A.80:6366-6370(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LOS ANGELES SER-48
    20. 20.
      "Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution."
      Shoelson S. , Fickova M. , Haneda M. , Nahum A. , Musso G. , Kaiser E.T. , Rubenstein A.H. , Tager H.
      Proc. Natl. Acad. Sci. U.S.A.80:7390-7394(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LOS ANGELES SER-48 AND CHICAGO LEU-49
    21. 21.
      "A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia."
      Chan S.J. , Seino S. , Gruppuso P.A. , Schwartz R. , Steiner D.F.
      Proc. Natl. Acad. Sci. U.S.A.84:2194-2197(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHPRI ASP-34
    22. 22.
      "Structurally abnormal insulin in a diabetic patient. Characterization of the mutant insulin A3 (Val-->Leu) isolated from the pancreas."
      Sakura H. , Iwamoto Y. , Sakamoto Y. , Kuzuya T. , Hirata H.
      J. Clin. Invest.78:1666-1672(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT WAKAYAMA LEU-92
    23. 23.
      "Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by polymerase chain reaction."
      Barbetti F. , Raben N. , Kadowaki T. , Cama A. , Accili D. , Gabbay K.H. , Merenich J.A. , Taylor S.I. , Roth J.
      J. Clin. Endocrinol. Metab.71:164-169(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHPRI HIS-89
    24. 24.
      "Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia."
      Shibasaki Y. , Kawakami T. , Kanazawa Y. , Akanuma Y. , Takaku F.
      J. Clin. Invest.76:378-380(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHPRI HIS-89
    25. 25.
      "A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto)."
      Yano H. , Kitano N. , Morimoto M. , Polonsky K.S. , Imura H. , Seino Y.
      J. Clin. Invest.89:1902-1907(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHPRI LEU-89
    26. 26.
      "Toward the solution structure of human insulin: sequential 2D 1H NMR assignment of a des-pentapeptide analogue and comparison with crystal structure."
      Hua Q.-X. , Weiss M.A.
      Biochemistry29:10545-10555(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    27. 27.
      "Comparative 2D NMR studies of human insulin and des-pentapeptide insulin: sequential resonance assignment and implications for protein dynamics and receptor recognition."
      Hua Q.-X. , Weiss M.A.
      Biochemistry30:5505-5515(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    28. 28.
      "Two-dimensional NMR studies of Des-(B26-B30)-insulin: sequence-specific resonance assignments and effects of solvent composition."
      Hua Q.-X. , Weiss M.A.
      Biochim. Biophys. Acta1078:101-110(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    29. 29.
      "Three-dimensional solution structure of an insulin dimer. A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics."
      Joergensen A.M.M. , Kristensen S.M. , Led J.J. , Balschmidt P.
      J. Mol. Biol.227:1146-1163(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    30. 30.
      "Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus."
      Hua Q.-X. , Shoelson S.E. , Inouye K. , Weiss M.A.
      Proc. Natl. Acad. Sci. U.S.A.90:582-586(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF VARIANT LOS-ANGELES SER-48
    31. 31.
      "Solution structures of the R6 human insulin hexamer."
      Chang X. , Joergensen A.M. , Bardrum P. , Led J.J.
      Biochemistry36:9409-9422(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    32. 32.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PNDM ASP-24; ARG-32; SER-32; GLY-43; VAL-47; CYS-48; CYS-89; CYS-90; TYR-96 AND CYS-108
    33. 33.
      "Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood."
      Edghill E.L. , Flanagan S.E. , Patch A.M. , Boustred C. , Parrish A. , Shields B. , Shepherd M.H. , Hussain K. , Kapoor R.R. , Malecki M. , MacDonald M.J. , Stoy J. , Steiner D.F. , Philipson L.H. , Bell G.I. , Hattersley A.T. , Ellard S.
      Diabetes57:1034-1042(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PNDM ASP-24; ASP-29; ARG-32; SER-32; PRO-35; GLY-43; VAL-47; CYS-48; ARG-84; CYS-89; CYS-90; SER-96; TYR-96; CYS-101; CYS-103 AND CYS-108;VARIANT MODY10 CYS-6;VARIANT MET-68
    34. 34.
      "Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes."
      Molven A. , Ringdal M. , Nordbo A.M. , Raeder H. , Stoy J. , Lipkind G.M. , Steiner D.F. , Philipson L.H. , Bergmann I. , Aarskog D. , Undlien D.E. , Joner G. , Sovik O. , Bell G.I. , Njolstad P.R.
      Diabetes57:1131-1135(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MODY10 GLN-46;VARIANT IDDM2 CYS-55
    35. 35.
      "Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)."
      Boesgaard T.W. , Pruhova S. , Andersson E.A. , Cinek O. , Obermannova B. , Lauenborg J. , Damm P. , Bergholdt R. , Pociot F. , Pisinger C. , Barbetti F. , Lebl J. , Pedersen O. , Hansen T.
      BMC Med. Genet.11:42-42(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MODY10 HIS-6 AND GLN-46
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