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Index > Protein center > Ints3(Gene name) > Mouse
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  • Ints3 (Gene name),
  • Integrator complex subunit 3 (Protein name ),  INT3_MOUSE from NCBI database.
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  • Antigen Annotation
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  • Gene name:
    Ints3;
    Protein name:
    Integrator complex subunit 3(Int3);
    Alternative:
    Sensor of single-strand DNA complex subunit A(SOSS-A;Sensor of ssDNA subunit A);SOSS complex subunit A;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/SSBIP1. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Interacts with SOSS-B1/OBFC2B, SOSS-B2/OBFC2A and SOSS-C/SSBIP1; the interaction is direct. Interacts with NBN/NBS1.
    Function:
    Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
    Subcellular Location:
    Nucleus Localizes to nuclear foci following DNA damage.
    Protein Attributes:
    Sequence length:
    1041
    Sequence:
    50:
    MELQKGKGTV | AAAASGAAGG | GGGGAGAGAP | GGGRLLLSTS | LDAKDELEER | 
    100:
    LERCMSIVTS | MTAGVSEREA | NDALNAYVCK | GPPQHEEICL | GLFTLVLTEP | 
    150:
    AQAQKCYRDL | ALVSRDGMNI | VLNKINQLLM | EKYLKLQDTC | RTQLVWLVRE | 
    200:
    LVKSGVLGAD | GVCMTFMKQI | AGGDVTAKNI | WLAESVLDIL | TEQREWVLKS | 
    250:
    SILIAMAVYT | YLRLIVDHHG | TAQLQTLRQK | EVDFCISLLR | ERFMECLMIG | 
    300:
    RDLVRLLQNV | ARIPEFELLW | KDIIHNPQAL | SPQFTGILQL | LQSRTSRKFL | 
    350:
    ACRLTPDMET | KLLFMTSRVR | FGQQKRYQDW | FQRQYLSTPD | SQSLRCDLIR | 
    400:
    YICGVVHPSN | EVLSSDILPR | WAIIGWLLTT | CTSNVAASNA | KLALFYDWLF | 
    450:
    FSPEKDSIMN | IEPAILVMHH | SMKPHPAITA | TLLDFMCRII | PNFYPPLEGH | 
    500:
    VRQGVFSSLN | HIVEKRVLAH | LAPLFDNPKL | DKELRSMLRE | KFPEFCSSPS | 
    550:
    PPVEVKIEEP | VSMEMDNHLS | DKDESCYDNA | EAAFSDDEED | LNSKGKKREF | 
    600:
    RFHPIKETVV | EEPVDVTPYL | DQLDESLRDK | VLQLQKGSDT | EAQCEVMQEI | 
    650:
    VDQVLEEDFD | SEQLSVLASC | LQELFKAHFR | GEVLPEEVTE | ESLEESVGKP | 
    700:
    LYLIFRNLCQ | MQEDNSSFSL | LLDLLSELYQ | KQPKIGYHLL | YYLRASKAAA | 
    750:
    GKMNLYESFA | QATQLGDLHT | CLMMDMKACQ | EDDVRLLCHL | TPSIYTEFPD | 
    800:
    ETLRSGELLN | MIVAVIDSAQ | LQELVCHVMM | GNLVMFRKDS | VLNILIQSLD | 
    850:
    WETFEQYCAW | QLFLAHNIPL | ETIIPILQHL | KYKEHPEALS | CLLLQLRREK | 
    900:
    PSEEMVKMVL | SRPCHPDDQF | TTSILRHWCM | KHDELLAEHI | KALLIKNNSL | 
    950:
    PRKRQSLRSS | SSKLAQLTLE | QILEHLDNLR | LNLANTKQNF | FSQTPILQAL | 
    1000:
    QHVQASCDEA | HKMKFSDLFS | LAEEYEDSST | KPPKSRRKAA | LSSPRSRKNA | 
    1041:
    TQPPNAEEES | GSSSASEEED | TKPKPTKRKR | KGSSAVGSDS | D
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Int3
    Cat.:
    E0291h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Int3
    Cat.:
    E0291m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Int3
    Cat.:
    U0291h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Int3
    Cat.:
    U0291m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Int3
    Cat.:
    P0291Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Int3
    Cat.:
    P0291Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Int3
    Monoclonal Antibody for Mouse Int3
    Protein for Mouse Int3
    Protein for Mouse Int3

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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 460-1041 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Thymus.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      strain: Czech II.
      tissue: Brain.
      tissue: Mammary tumor.
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