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Index > Protein center > Dio2(Gene name) > Rat
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  • Dio2 (Gene name),
  • Type II iodothyronine deiodinase (Protein name ),  IOD2_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Dio2(Itdi2;Txdi2);
    Protein name:
    Type II iodothyronine deiodinase;
    Alternative:
    DIOII;5DII;Type-II 5'-deiodinase;Type 2 DI;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with USP20 and USP33. Interacts with MARCH6.
    Function:
    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
    Subcellular Location:
    Membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    266
    Sequence:
    50:
    MGLLSVDLLI | TLQILPVFFS | NCLFLALYDS | VILLKHVALL | LSRSKSTRGE | 
    100:
    WRRMLTSEGL | RCVWNSFLLD | AYKQVKLGED | APNSSVVHVS | NPEAGNNCAS | 
    150:
    EKTADGAECH | LLDFASAERP | LVVNFGSATU | PPFTRQLPAF | RQLVEEFSSV | 
    200:
    ADFLLVYIDE | AHPSDGWAVP | GDSSMSFEVK | KHRNQEDRCA | AAHQLLERFS | 
    250:
    LPPQCQVVAD | RMDNNANVAY | GVAFERVCIV | QRRKIAYLGG | KGPFSYNLQE | 
    266:
    VRSWLEKNFS | KRUILD
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    E0578h
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    96T
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    ELISA Kit for Rat Type II iodothyronine deiodinase
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    E0578r
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    ELISA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    E0578m
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    ELISA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    E0578b
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    ELISA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    E0578c
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    Packing:
    96T
    ELISA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    E0578p
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    Packing:
    96T
    CLIA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    U0578c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    U0578b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    U0578m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    U0578h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    U0578r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Type II iodothyronine deiodinase
    Cat.:
    U0578p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Type II iodothyronine deiodinase
    Cat.:
    P0578Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Type II iodothyronine deiodinase
    Cat.:
    P0578Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Type II iodothyronine deiodinase
    Cat.:
    P0578Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Type II iodothyronine deiodinase
    Polyclonal Antibody for Rat Type II iodothyronine deiodinase
    Polyclonal Antibody for Rat Type II iodothyronine deiodinase
    Monoclonal Antibody for Rat Type II iodothyronine deiodinase
    Monoclonal Antibody for Rat Type II iodothyronine deiodinase
    Monoclonal Antibody for Rat Type II iodothyronine deiodinase
    Monoclonal Antibody for Rat Type II iodothyronine deiodinase
    Monoclonal Antibody for Rat Type II iodothyronine deiodinase
    Monoclonal Antibody for Rat Type II iodothyronine deiodinase
    Protein for Rat Type II iodothyronine deiodinase
    Protein for Rat Type II iodothyronine deiodinase
    Protein for Rat Type II iodothyronine deiodinase
    Protein for Rat Type II iodothyronine deiodinase
    Protein for Rat Type II iodothyronine deiodinase
    Protein for Rat Type II iodothyronine deiodinase

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues."
      Croteau W. , Davey J.C. , Galton V.A. , St Germain D.L.
      J. Clin. Invest.98:405-417(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION
      strain: Sprague-Dawley.
      tissue: Brown adipose tissue.
    2. 2.
      "Induction of type 2 deiodinase activity by cyclic guanosine 3',5'-monophosphate in cultured rat glial cells."
      Gondou A. , Toyoda N. , Nishikawa M. , Tabata S. , Yonemoto T. , Ogawa Y. , Tokoro T. , Sakaguchi N. , Wang F. , Inada M.
      Thyroid8:615-622(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Expression and nocturnal increase of type II iodothyronine deiodinase mRNA in rat pineal gland."
      Murakami M. , Hosoi Y. , Negishi T. , Kamiya Y. , Ogiwara T. , Mizuma H. , Yamada M. , Iriuchijima T. , Mori M.
      Neurosci. Lett.227:65-67(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
    4. 4.
      "Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling."
      Bailey M.J. , Coon S.L. , Carter D.A. , Humphries A. , Kim J.S. , Shi Q. , Gaildrat P. , Morin F. , Ganguly S. , Hogenesch J.B. , Weller J.L. , Rath M.F. , Moller M. , Baler R. , Sugden D. , Rangel Z.G. , Munson P.J. , Klein D.C.
      J. Biol. Chem.284:7606-7622(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
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