IREB2 ELISA Kit for Human(Homo sapiens) | EIAab.comIREB2 ELISA Kit for Human(Homo sapiens)

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IREB2 (Gene name),

Iron-responsive element-binding protein 2 (Protein name ), IREB2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IREB2;

Protein name:

Iron-responsive element-binding protein 2(IRE-BP 2);

Alternative:

Iron regulatory protein 2(IRP2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with RBCK1 isoform 1 and isoform 2 only in iron-rich conditions. Interacts (when associated with the 4Fe-4S) with FBXL5.

Function:

RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

963

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

963:

HGGLLNFVAR | KFS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:3658

MIM:

147582

STRING:

9606.ENSP00000258886

UniGene:

Hs.436031

String:

P48200

SMR:

P48200

Pfam:

PF00330

Uniprot:

P48200

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ELISA Kit for Human IRE-BP 2

Cat.:

E13568h

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96T

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ELISA Kit for Human IRE-BP 2

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ELISA Kit for Human IRE-BP 2

Cat.:

E13568r

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96T

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ELISA Kit for Human IRE-BP 2

Cat.:

E13568m

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Packing:

96T

ELISA Kit for Human IRE-BP 2

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CLIA Kit for Human IRE-BP 2

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CLIA Kit for Human IRE-BP 2

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CLIA Kit for Human IRE-BP 2

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CLIA Kit for Human IRE-BP 2

Cat.:

U13568h

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96T

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CLIA Kit for Human IRE-BP 2

Cat.:

U13568m

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Packing:

96T

Polyclonal Antibody for Human IRE-BP 2

Monoclonal Antibody for Human IRE-BP 2

Protein for Human IRE-BP 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation."
Samaniego F. , Chin J. , Iwai K. , Rouault T.A. , Klausner R.D.
J. Biol. Chem.269:30904-30910(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;RNA-BINDING;VARIANTS LEU-159 AND THR-580
2.

"IgA nephropathy-related gene."
Ishiwata T. , Sakurada M. , Nishimura A. , Nakagawa S. , Nishi T. , Kuga T. , Sawada S. , Takei M.
Submitted (2010-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT LEU-159
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS LEU-159 AND THR-580
tissue: Trachea.
4.

"Homo sapiens protein coding cDNA."
Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS LEU-159 AND THR-580
tissue: Brain.
5.

NIEHS SNPs program
Submitted (2006-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-159 AND THR-580
6.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS LEU-159 AND THR-580
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS LEU-159 AND THR-580
tissue: Brain.
9.

"Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein."
Rouault T.A. , Tang C.K. , Kaptain S. , Burgess W.H. , Haile D.J. , Samaniego F. , McBride O.W. , Harford J.B. , Klausner R.D.
Proc. Natl. Acad. Sci. U.S.A.87:7958-7962(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA];VARIANTS LEU-159 AND THR-580
10.

"Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels."
Guo B. , Brown F.M. , Phillips J.D. , Yu Y. , Leibold E.A.
J. Biol. Chem.270:16529-16535(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-963 (ISOFORM 1)
tissue: Brain.
11.

The European IMAGE consortium
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 847-963 (ISOFORM 1)
12.

"Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2."
Yamanaka K. , Ishikawa H. , Megumi Y. , Tokunaga F. , Kanie M. , Rouault T.A. , Morishima I. , Minato N. , Ishimori K. , Iwai K.
Nat. Cell Biol.5:336-340(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH RBCK1
13.

"Control of iron homeostasis by an iron-regulated ubiquitin ligase."
Vashisht A.A. , Zumbrennen K.B. , Huang X. , Powers D.N. , Durazo A. , Sun D. , Bhaskaran N. , Persson A. , Uhlen M. , Sangfelt O. , Spruck C. , Leibold E.A. , Wohlschlegel J.A.
Science326:718-721(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH FBXL5
14.

"An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis."
Salahudeen A.A. , Thompson J.W. , Ruiz J.C. , Ma H.-W. , Kinch L.N. , Li Q. , Grishin N.V. , Bruick R.K.
Science326:722-726(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH FBXL5
15.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-159;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.

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