Protein name:
Iron-responsive element-binding protein 2 (IRE-BP 2) ;
Alternative:
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Interacts with RBCK1 only in iron-rich conditions. Interacts (when associated with the 4Fe-4S) with FBXL5.
Function:
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MDAPSAGYAF | EYLIETLNDS | SHKKFFNVPR | LGGTKYDVLP | YSIRVLLEAA |
100:
VRNCDGFLMK | KEDVMNILDW | KTKQSNVEVP | FFPGRVLLQD | FTGIPAMVDF |
150:
AAMREAVKTL | GGDPKKVHPA | CPTDLTVDHS | LQIDFNKCAI | QNAPNPGGGD |
200:
LQKAGKLSPL | RVQPKKLPCR | GQTACRGSCD | SGDLGRNSGK | FSSQIENTPI |
250:
LCPFHLQPVP | EPETVLKNQE | VEFGRNRERL | QFFKWSSRVF | KNVAVIPPGT |
300:
GMAHQVNLEY | LSRVVFEEKD | LLFPDSVVGT | DSHITMVNGL | GILGWGVGGI |
350:
ETEAVMLGLP | VSLTLPEVVG | CELTGSSNPF | VTSIDVVLGI | TKHLRQIGVA |
400:
GKFVEFFGSG | VSQLSIVDRT | TIANMCPEYG | AILSFFPVDN | VTLKHLEYTG |
450:
FNKAKLKSME | TYLKAVKLFR | NDQDNSGEPE | YSQVIQINLN | SIVPSVSGPK |
500:
RPQDRVAVTD | MKSDFQACLN | EKVGFKGFQI | AAEKQNDTVS | IHYEGSEYKL |
550:
SHGSVVIAAV | ISCTNNCNPS | VMLAAGLLAK | KAVEAGLRVK | PYIRTSLSPG |
600:
SGMVTHYLSS | SGVLPYLSKL | GFEIVGYGCS | TCVGNTAPLS | EAVLNAVKQG |
650:
DLVTCGVLSG | NKNFEGRLCD | CVRANYLASP | PLVVAYAIAG | TVNIDFRTEP |
700:
LGTDPTGKNI | YLHDIWPSRE | EVHQIEEEHV | VLSMFKALKE | KIEMGNKRWN |
750:
SLEAPDSVLF | PWDLKSTYIR | CPSFFDKLTK | EPVALQPIEN | AHVLLYLGDS |
800:
VTTDHISPAG | SIARSSAAAK | YLTNRGLTPR | EFNSYGARRG | NDAVMTRGTF |
850:
ANIKLFNKFI | GKPAPKTIHF | PSGQTLDVFE | AAELYQKEGI | PLIILAGKKY |
900:
GSGNSRDWAA | KGPYLLGVKA | VLAESYEKIH | KDHLIGIGIA | PLQFLPGENA |
950:
DSLGLSGRET | FSLTFPEELS | PGVTLNIKTS | TGKIFSVIAS | FENDVEIILY |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Rat
Mouse
Pig
ELISA Kit for Pig IRE-BP 2
ELISA Kit for Pig IRE-BP 2
ELISA Kit for Pig IRE-BP 2
ELISA Kit for Pig IRE-BP 2
ELISA Kit for Pig IRE-BP 2
CLIA Kit for Pig IRE-BP 2
CLIA Kit for Pig IRE-BP 2
CLIA Kit for Pig IRE-BP 2
CLIA Kit for Pig IRE-BP 2
CLIA Kit for Pig IRE-BP 2
Polyclonal Antibody for Pig IRE-BP 2
Polyclonal Antibody for Pig IRE-BP 2
Polyclonal Antibody for Pig IRE-BP 2
Polyclonal Antibody for Pig IRE-BP 2
Polyclonal Antibody for Pig IRE-BP 2
Monoclonal Antibody for Pig IRE-BP 2
Monoclonal Antibody for Pig IRE-BP 2
Monoclonal Antibody for Pig IRE-BP 2
Monoclonal Antibody for Pig IRE-BP 2
Monoclonal Antibody for Pig IRE-BP 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]