IRF1 ELISA Kit for Human(Homo sapiens) | EIAab.comIRF1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > IRF1(Gene name) > Human

IRF1 (Gene name),

Interferon regulatory factor 1 (Protein name ), IRF1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IRF1;

Protein name:

Interferon regulatory factor 1(IRF-1);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

325

Sequence:

50:

100:

150:

200:

250:

300:

325:

MDATWLDSLL | TPVRLPSIQA | IPCAP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P10914

Pfam:

PF00605

KEGG:

hsa:3659

SMR:

P10914

MIM:

147575

UniGene:

Hs.436061

STRING:

9606.ENSP00000245414

Uniprot:

P10914

FOR

ELISA Kit for Human IRF-1

Cat.:

E1564r

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Packing:

96T

ELISA Kit for Human IRF-1

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E1564m

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MSDS:

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96T

ELISA Kit for Human IRF-1

Cat.:

E1564b

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96T

ELISA Kit for Human IRF-1

Cat.:

E1564c

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96T

ELISA Kit for Human IRF-1

Cat.:

E1564h

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Manual:

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96T

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ELISA Kit for Human IRF-1

Cat.:

E1564p

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96T

CLIA Kit for Human IRF-1

Cat.:

U1564m

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96T

CLIA Kit for Human IRF-1

Cat.:

U1564p

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96T

CLIA Kit for Human IRF-1

Cat.:

U1564h

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96T

CLIA Kit for Human IRF-1

Cat.:

U1564c

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96T

CLIA Kit for Human IRF-1

Cat.:

U1564b

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96T

CLIA Kit for Human IRF-1

Cat.:

U1564r

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96T

Polyclonal Antibody for Human IRF-1

Cat.:

P1564Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human IRF-1

Cat.:

P1564Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human IRF-1

Cat.:

P1564Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IRF-1

Protein for Human IRF-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Sequence of a cDNA coding for human IRF-1."
Maruyama M. , Fujita T. , Taniguchi T.
Nucleic Acids Res.17:3292-3292(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements."
Miyamoto M. , Fujita T. , Kimura Y. , Maruyama M. , Harada H. , Sudo Y. , Miyata T. , Taniguchi T.
Cell54:903-913(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Human interferon regulatory factor 1: intron-exon organization."
Cha Y. , Sims S.H. , Romine M.F. , Kaufmann M. , Deisseroth A.B.
DNA Cell Biol.11:605-611(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Pancreas.
6.

"Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia."
Willman C.L. , Sever C.E. , Pallavicini M.G. , Harada H. , Tanaka N. , Slovak M.L. , Yamamoto H. , Harada K. , Meeker T.C. , List A.F. , Taniguchi T.
Science259:968-971(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LEUKEMIAS
7.

"A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity."
Lin R. , Hiscott J.
Mol. Cell. Biochem.191:169-180(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
8.

"IRF family of transcription factors as regulators of host defense."
Taniguchi T. , Ogasawara K. , Takaoka A. , Tanaka N.
Annu. Rev. Immunol.19:623-655(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
9.

"Activities of IRF-1."
Kroeger A. , Koester M. , Schroeder K. , Hauser H. , Mueller P.P.
J. Interferon Cytokine Res.22:5-14(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
10.

"IRF-1 as a negative regulator of cell proliferation."
Romeo G. , Fiorucci G. , Chiantore M.V. , Percario Z.A. , Vannucchi S. , Affabris E.
J. Interferon Cytokine Res.22:39-47(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
11.

"Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells."
Oshima S. , Nakamura T. , Namiki S. , Okada E. , Tsuchiya K. , Okamoto R. , Yamazaki M. , Yokota T. , Aida M. , Yamaguchi Y. , Kanai T. , Handa H. , Watanabe M.
Mol. Cell. Biol.24:6298-6310(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53."
Dornan D. , Eckert M. , Wallace M. , Shimizu H. , Ramsay E. , Hupp T.R. , Ball K.L.
Mol. Cell. Biol.24:10083-10098(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EP300
13.

"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors."
Honda K. , Taniguchi T.
Nat. Rev. Immunol.6:644-658(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
14.

"Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression."
Su Z.Z. , Sarkar D. , Emdad L. , Barral P.M. , Fisher P.B.
J. Cell. Physiol.213:502-510(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II."
Maratheftis C.I. , Giannouli S. , Spachidou M.P. , Panayotou G. , Voulgarelis M.
Neoplasia9:1012-1020(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis."
Park J. , Kim K. , Lee E.-J. , Seo Y.-J. , Lim S.-N. , Park K. , Rho S.B. , Lee S.-H. , Lee J.-H.
Proc. Natl. Acad. Sci. U.S.A.104:17028-17033(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-275 AND LYS-299;UBIQUITINATION AT LYS-275 AND LYS-299;FUNCTION;MUTAGENESIS OF LYS-275 AND LYS-299
17.

"IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis."
Bowie M.L. , Ibarra C. , Seewalt V.L.
Adv. Exp. Med. Biol.617:367-374(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression."
Fragale A. , Gabriele L. , Stellacci E. , Borghi P. , Perrotti E. , Ilari R. , Lanciotti A. , Remoli A.L. , Venditti M. , Belardelli F. , Battistini A.
J. Immunol.181:1673-1682(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages."
Huang Y. , Walstrom A. , Zhang L. , Zhao Y. , Cui M. , Ye L. , Zheng J.C.
PLoS ONE4:E5397-E5397(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"Regulation of immunity and oncogenesis by the IRF transcription factor family."
Savitsky D. , Tamura T. , Yanai H. , Taniguchi T.
Cancer Immunol. Immunother.59:489-510(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
21.

"IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells."
Gao J. , Senthil M. , Ren B. , Yan J. , Xing Q. , Yu J. , Zhang L. , Yim J.H.
Cell Death Differ.17:699-709(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
22.

"Human papillomavirus type 16 E5 protein induces expression of beta interferon through interferon regulatory factor 1 in human keratinocytes."
Muto V. , Stellacci E. , Lamberti A.G. , Perrotti E. , Carrabba A. , Matera G. , Sgarbanti M. , Battistini A. , Liberto M.C. , Foca A.
J. Virol.85:5070-5080(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"Interferon regulatory factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells."
Armstrong M.J. , Stang M.T. , Liu Y. , Gao J. , Ren B. , Zuckerbraun B.S. , Mahidhara R.S. , Xing Q. , Pizzoferrato E. , Yim J.H.
Cancer Lett.319:56-65(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
24.

"Interferon regulatory factor 1 transactivates the expression of human DNA polymerase eta in response to the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine."
Qi H. , Zhu H. , Lou M. , Fan Y. , Liu H. , Shen J. , Li Z. , Lv X. , Shan J. , Zhu L. , Chin Y.E. , Shao J.
J. Biol. Chem.287:12622-12633(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACETYLATION AT LYS-78;MUTAGENESIS OF LYS-78
25.

"Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer."
Nozawa H. , Oda E. , Ueda S. , Tamura G. , Maesawa C. , Muto T. , Taniguchi T. , Tanaka N.
Int. J. Cancer77:522-527(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GASC LEU-8;CHARACTERIZATION OF VARIANT GASC LEU-8
26.

"Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding."
Eason D.D. , Shepherd A.T. , Blanck G.
Biochim. Biophys. Acta1446:140-144(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GASC ARG-11

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