Irf2 ELISA Kit for Mouse(Mus musculus) | EIAab.comIrf2 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Irf2(Gene name) > Mouse

Irf2 (Gene name),

Interferon regulatory factor 2 (Protein name ), IRF2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Irf2;

Protein name:

Interferon regulatory factor 2(IRF-2);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity.

Function:

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

349

Sequence:

50:

100:

150:

200:

250:

300:

349:

YNSSWPPFTD | LPLPAPVTPT | PSSSRPDRET | RASVIKKTSD | ITQARVKSC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P23906

Pfam:

PF00605

UniGene:

Mm.1149

SMR:

P23906

KEGG:

mmu:16363

Uniprot:

P23906

FOR

ELISA Kit for Mouse IRF-2

CLIA Kit for Mouse IRF-2

Polyclonal Antibody for Mouse IRF-2

Monoclonal Antibody for Mouse IRF-2

Protein for Mouse IRF-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes."
Harada H. , Fujita T. , Miyamoto M. , Kimura Y. , Maruyama M. , Furia A. , Miyata T. , Taniguchi T.
Cell58:729-739(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Lubec G. , Sunyer B. , Chen W.-Q.
Submitted (2009-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 108-120;IDENTIFICATION BY MASS SPECTROMETRY
strain: OF1.
tissue: Hippocampus.
3.

"Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family."
Furui J. , Uegaki K. , Yamazaki T. , Shirakawa M. , Swindells M.B. , Harada H. , Taniguchi T. , Kyogoku Y.
Structure6:491-500(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 2-113
4.

"Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences."
Fujii Y. , Shimizu T. , Kusumoto M. , Kyogoku Y. , Taniguchi T. , Hakoshima T.
EMBO J.18:5028-5041(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-113

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