IRF8 ELISA Kit for Human(Homo sapiens) | EIAab.comIRF8 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > IRF8(Gene name) > Human

IRF8 (Gene name),

Interferon regulatory factor 8 (Protein name ), IRF8_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IRF8(ICSBP1);

Protein name:

Interferon regulatory factor 8(IRF-8);

Alternative:

Interferon consensus sequence-binding protein(H-ICSBP;ICSBP);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (via C-terminus) with TRIM21 (via C-terminus) (By similarity). Interacts with COPS2.

Function:

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

426

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

426:

QVFRMFPDIC | ASHQRSFFRE | NQQITV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.137427

Pfam:

PF00605

SMR:

Q02556

String:

Q02556

KEGG:

hsa:3394

MIM:

601565

STRING:

9606.ENSP00000268638

Uniprot:

Q02556

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ELISA Kit for Human IRF-8

Cat.:

E1776h

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Packing:

96T

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ELISA Kit for Human IRF-8

Cat.:

E1776m

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Manual:

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96T

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ELISA Kit for Human IRF-8

Cat.:

E1776c

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MSDS:

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Packing:

96T

CLIA Kit for Human IRF-8

Cat.:

U1776h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human IRF-8

Cat.:

U1776m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human IRF-8

Cat.:

U1776c

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Packing:

96T

Polyclonal Antibody for Human IRF-8

Cat.:

P1776Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IRF-8

Cat.:

P1776Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IRF-8

Protein for Human IRF-8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes."
Weisz A. , Marx P. , Sharf R. , Appella E. , Driggers P.H. , Ozato K. , Levi B.-Z.
J. Biol. Chem.267:25589-25596(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION BY IFNG
tissue: Lung.
tissue: Monocyte.
2.

Schmidt M.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
4.

"Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome."
Cohen H. , Azriel A. , Cohen T. , Meraro D. , Hashmueli S. , Bech-Otschir D. , Kraft R. , Dubiel W. , Levi B.Z.
J. Biol. Chem.275:39081-39089(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS2
5.

"BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."
Basso K. , Schneider C. , Shen Q. , Holmes A.B. , Setty M. , Leslie C. , Dalla-Favera R.
J. Exp. Med.209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-81 AND THR-197
7.

"IRF8 mutations and human dendritic-cell immunodeficiency."
Hambleton S. , Salem S. , Bustamante J. , Bigley V. , Boisson-Dupuis S. , Azevedo J. , Fortin A. , Haniffa M. , Ceron-Gutierrez L. , Bacon C.M. , Menon G. , Trouillet C. , McDonald D. , Carey P. , Ginhoux F. , Alsina L. , Zumwalt T.J. , Kong X.F. , more...
N. Engl. J. Med.365:127-138(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IMD32A ALA-80;VARIANT IMD32B GLU-108;CHARACTERIZATION OF VARIANT IMD32A ALA-80;CHARACTERIZATION OF VARIANT IMD32B GLU-108

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