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Index > Protein center > Irgm1(Gene name) > Mouse
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  • Irgm1 (Gene name),
  • Immunity-related GTPase family M protein 1 (Protein name ),  IRGM1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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    • Gene name:
    Irgm1(Ifi1;Iigp3;Irgm);
    Protein name:
    Immunity-related GTPase family M protein 1;
    Alternative:
    Interferon-inducible protein 1;Interferon-inducible GTPase 3;LPS-stimulated RAW 264.7 macrophage protein 47(LRG-47);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion.
    Subcellular Location:
    Golgi apparatus membrane Cell membrane Cytoplasmic vesicle phagosome membrane Cytoplasmic vesicle autophagosome membrane Lysosome membrane Late endosome membrane Cell projection phagocytic cup Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes. Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent. Preferentially associated with cis- and medial-Golgi. Also detected in late endosomes and lysosomes.
    Protein Attributes:
    Sequence length:
    409
    Sequence:
    50:
    MKPSHSSCEA | APLLPNMAET | HYAPLSSAFP | FVTSYQTGSS | RLPEVSRSTE | 
    100:
    RALREGKLLE | LVYGIKETVA | TLSQIPVSIF | VTGDSGNGMS | SFINALRVIG | 
    150:
    HDEDASAPTG | VVRTTKTRTE | YSSSHFPNVV | LWDLPGLGAT | AQTVEDYVEE | 
    200:
    MKFSTCDLFI | IIASEQFSSN | HVKLSKIIQS | MGKRFYIVWT | KLDRDLSTSV | 
    250:
    LSEVRLLQNI | QENIRENLQK | EKVKYPPVFL | VSSLDPLLYD | FPKLRDTLHK | 
    300:
    DLSNIRCCEP | LKTLYGTYEK | IVGDKVAVWK | QRIANESLKN | SLGVRDDDNM | 
    350:
    GECLKVYRLI | FGVDDESVQQ | VAQSMGTVVM | EYKDNMKSQN | FYTLRREDWK | 
    400:
    LRLMTCAIVN | AFFRLLRFLP | CVCCCLRRLR | HKRMLFLVAQ | DTKNILEKIL | 
    409:
    RDSIFPPQI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    mmu:15944
    String:
    Q60766
    Pfam:
    PF05049
    UniGene:
    Mm.29938
    SMR:
    Q60766
    Uniprot:
    Q60766
     
    FOR
    ELISA Kit for Mouse Immunity-related GTPase family M protein 1
    CLIA Kit for Mouse Immunity-related GTPase family M protein 1
    Polyclonal Antibody for Mouse Immunity-related GTPase family M protein 1
    Monoclonal Antibody for Mouse Immunity-related GTPase family M protein 1
    Protein for Mouse Immunity-related GTPase family M protein 1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family."
      Sorace J.M. , Johnson R.J. , Howard D.L. , Drysdale B.E.
      J. Leukoc. Biol.58:477-484(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION BY LPS AND IFNG
      strain: BALB/c.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Kidney.
      tissue: Placenta.
      tissue: Spleen.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma."
      Taylor G.A. , Jeffers M. , Largaespada D.A. , Jenkins N.A. , Copeland N.G. , Vande Woude G.F.
      J. Biol. Chem.271:20399-20405(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY
    6. 6.
      "Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection."
      Collazo C.M. , Yap G.S. , Sempowski G.D. , Lusby K.C. , Tessarollo L. , Vande Woude G.F. , Sher A. , Taylor G.A.
      J. Exp. Med.194:181-188(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;INDUCTION
    7. 7.
      "Immune control of tuberculosis by IFN-gamma-inducible LRG-47."
      MacMicking J.D. , Taylor G.A. , McKinney J.D.
      Science302:654-659(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;INDUCTION
    8. 8.
      "Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages."
      Gutierrez M.G. , Master S.S. , Singh S.B. , Taylor G.A. , Colombo M.I. , Deretic V.
      Cell119:753-766(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia."
      Feng C.G. , Collazo-Custodio C.M. , Eckhaus M. , Hieny S. , Belkaid Y. , Elkins K. , Jankovic D. , Taylor G.A. , Sher A.
      J. Immunol.172:1163-1168(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    10. 10.
      "Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosis."
      Martens S. , Sabel K. , Lange R. , Uthaiah R. , Wolf E. , Howard J.C.
      J. Immunol.173:2594-2606(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY;INDUCTION BY IFNG;MUTAGENESIS OF SER-90
    11. 11.
      "p47 GTPases regulate Toxoplasma gondii survival in activated macrophages."
      Butcher B.A. , Greene R.I. , Henry S.C. , Annecharico K.L. , Weinberg J.B. , Denkers E.Y. , Sher A. , Taylor G.A.
      Infect. Immun.73:3278-3286(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    12. 12.
      "Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth."
      Santiago H.C. , Feng C.G. , Bafica A. , Roffe E. , Arantes R.M. , Cheever A. , Taylor G.A. , Vieira L.Q. , Aliberti J. , Gazzinelli R.T. , Sher A.
      J. Immunol.175:8165-8172(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    13. 13.
      "The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia."
      Bafica A. , Feng C.G. , Santiago H.C. , Aliberti J. , Cheever A. , Thomas K.E. , Taylor G.A. , Vogel S.N. , Sher A.
      J. Immunol.179:5514-5522(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY LPS
    14. 14.
      "Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47)."
      Henry S.C. , Daniell X. , Indaram M. , Whitesides J.F. , Sempowski G.D. , Howell D. , Oliver T. , Taylor G.A.
      J. Immunol.179:6963-6972(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells."
      Zhao Y.O. , Konen-Waisman S. , Taylor G.A. , Martens S. , Howard J.C.
      PLoS ONE5:E8648-E8648(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-356; ILE-358; VAL-359; PHE-362; PHE-363; LEU-365 AND LEU-366
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