Gene name:
Kcnj6 (Girk2;Kcnj7;W) ;
Protein name:
G protein-activated inward rectifier potassium channel 2 (GIRK-2) ;
Alternative:
Potassium channel, inwardly rectifying subfamily J member 6 ;Inward rectifier K(+) channel Kir3.2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
May associate with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.
Function:
This potassium channel is controlled by G proteins. It plays a role in granule cell differentiation, possibly via membrane hyperpolarization. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MTMAKLTESM | TNVLEGDSMD | QDVESPVAIH | QPKLPKQARD | DLPRHISRDR |
100:
TKRKIQRYVR | KDGKCNVHHG | NVRETYRYLT | DIFTTLVDLK | WRFNLLIFVM |
150:
VYTVTWLFFG | MIWWLIAYIR | GDMDHIEDPS | WTPCVTNLNG | FVSAFLFSIE |
200:
TETTIGYGYR | VITDKCPEGI | ILLLIQSVLG | SIVNAFMVGC | MFVKISQPKK |
250:
RAETLVFSTH | AVISMRDGKL | CLMFRVGDLR | NSHIVEASIR | AKLIKSKQTS |
300:
EGEFIPLNQS | DINVGYYTGD | DRLFLVSPLI | ISHEINQQSP | FWEISKAQLP |
350:
KEELEIVVIL | EGIVEATGMT | CQARSSYITS | EILWGYRFTP | VLTMEDGFYE |
400:
VDYNSFHETY | ETSTPSLSAK | ELAELANRAE | VPLSWSVSSK | LNQHAELETE |
425:
EEEKNPEELT | ERNGDVANLE | NESKV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Mouse GIRK-2
ELISA Kit for Mouse GIRK-2
ELISA Kit for Mouse GIRK-2
CLIA Kit for Mouse GIRK-2
CLIA Kit for Mouse GIRK-2
CLIA Kit for Mouse GIRK-2
Polyclonal Antibody for Mouse GIRK-2
Polyclonal Antibody for Mouse GIRK-2
Polyclonal Antibody for Mouse GIRK-2
Monoclonal Antibody for Mouse GIRK-2
Monoclonal Antibody for Mouse GIRK-2
Monoclonal Antibody for Mouse GIRK-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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