Irs1 ELISA Kit for Mouse(Mus musculus) | EIAab.comIrs1 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Irs1(Gene name) > Mouse

Irs1 (Gene name),

Insulin receptor substrate 1 (Protein name ), IRS1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Irs1(Irs-1);

Protein name:

Insulin receptor substrate 1(IRS-1);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7 (By similarity). Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif) (By similarity). Interacts with UBTF and PIK3CA. Interacts (via PH domain) with PHIP. Interacts with FER. Interacts with ALK.

Function:

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

1233

Sequence:

50:

100:

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350:

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450:

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1050:

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1150:

1200:

1233:

PLGSNEGNSP | RRSSEDLSNY | ASISFQKQPE | DRQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P35569

STRING:

10090.ENSMUSP00000063795

UniGene:

Mm.4952

String:

P35569

KEGG:

mmu:16367

Pfam:

PF02174

Uniprot:

P35569

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ELISA Kit for Mouse IRS-1

Cat.:

E1660h

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96T

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ELISA Kit for Mouse IRS-1

Cat.:

E1660m

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96T

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ELISA Kit for Mouse IRS-1

Cat.:

E1660r

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96T

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CLIA Kit for Mouse IRS-1

Cat.:

U1660r

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Packing:

96T

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CLIA Kit for Mouse IRS-1

Cat.:

U1660m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse IRS-1

Cat.:

U1660h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse IRS-1

Cat.:

P1660Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse IRS-1

Cat.:

P1660Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse IRS-1

Cat.:

P1660Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse IRS-1

Protein for Mouse IRS-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1."
Araki E. , Haag B.L. III , Kahn C.R.
Biochim. Biophys. Acta1221:353-356(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning."
Keller S.R. , Aebersold R. , Garner C.W. , Lienhard G.E.
Biochim. Biophys. Acta1172:323-326(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase."
Iwanishi M. , Czech M.P. , Cherniack A.D.
J. Biol. Chem.275:38995-39000(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FER
4.

"Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein."
Farhang-Fallah J. , Yin X. , Trentin G. , Cheng A.M. , Rozakis-Adcock M.
J. Biol. Chem.275:40492-40497(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PHIP
5.

"Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover."
Ogata N. , Chikazu D. , Kubota N. , Terauchi Y. , Tobe K. , Azuma Y. , Ohta T. , Kadowaki T. , Nakamura K. , Kawaguchi H.
J. Clin. Invest.105:935-943(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
6.

"5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside."
Jakobsen S.N. , Hardie D.G. , Morrice N. , Tornqvist H.E.
J. Biol. Chem.276:46912-46916(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-789
7.

"Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase."
Drakas R. , Tu X. , Baserga R.
Proc. Natl. Acad. Sci. U.S.A.101:9272-9276(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBTF AND PIK3CA;EFFECT ON CELL AND BODY SIZE
8.

"Role of Rho-kinase in regulation of insulin action and glucose homeostasis."
Furukawa N. , Ongusaha P. , Jahng W.J. , Araki K. , Choi C.S. , Kim H.J. , Lee Y.H. , Kaibuchi K. , Kahn B.B. , Masuzaki H. , Kim J.K. , Lee S.W. , Kim Y.B.
Cell Metab.2:119-129(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-632
9.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340 AND SER-1097;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
10.

"Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice."
Carvalho-Filho M.A. , Carvalho B.M. , Oliveira A.G. , Guadagnini D. , Ueno M. , Dias M.M. , Tsukumo D.M. , Hirabara S.M. , Reis L.F. , Curi R. , Carvalheira J.B. , Saad M.J.
Endocrinology153:5261-5274(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF2AK2

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