Irs1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comIrs1 ELISA Kit for Rat(Rattus norvegicus)

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Irs1 (Gene name),

Insulin receptor substrate 1 (Protein name ), IRS1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Irs1(Irs-1);

Protein name:

Insulin receptor substrate 1(IRS-1);

Alternative:

pp185;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with SOCS7 (By similarity). Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif) (By similarity). Interacts with UBTF, FER and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1. Interacts with ROCK1. Interacts (via PH domain) with PHIP. Interacts with GRB2. Interacts with ALK.

Function:

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

1235

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

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800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1235:

HQPLGSNEGS | SPRRSSEDLS | TYASINFQKQ | PEDRQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P35570

STRING:

10116.ENSRNOP00000019579

UniGene:

Rn.10476

SMR:

P35570

Pfam:

PF02174

KEGG:

rno:25467

Uniprot:

P35570

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ELISA Kit for Rat IRS-1

Cat.:

E1660h

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96T

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ELISA Kit for Rat IRS-1

Cat.:

E1660m

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96T

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ELISA Kit for Rat IRS-1

Cat.:

E1660r

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96T

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CLIA Kit for Rat IRS-1

Cat.:

U1660r

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Rat IRS-1

Cat.:

U1660m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat IRS-1

Cat.:

U1660h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat IRS-1

Cat.:

P1660Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat IRS-1

Cat.:

P1660Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat IRS-1

Cat.:

P1660Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat IRS-1

Protein for Rat IRS-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein."
Sun X.-J. , Rothenberg P.L. , Kahn C.R. , Backer J.M. , Araki E. , Wilden P.A. , Cahill D.A. , Goldstein B.J. , White M.F.
Nature352:73-77(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
strain: Sprague-Dawley.
tissue: Liver.
2.

"Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase."
Rothenberg P.L. , Lane W.S. , Karasik A. , Backer J.M. , White M.F. , Kahn C.R.
J. Biol. Chem.266:8302-8311(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 44-51; 173-178; 223-243; 489-506; 635-646; 932-947 AND 1098-1106
3.

"Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation."
Backer J.M. , Myers M.G. Jr. , Shoelson S.E. , Chin D.J. , Sun X.-J. , Miralpeix M. , Hu P. , Margolis B. , Skolnik E.Y. , Schlessinger J. , White M.F.
EMBO J.11:3469-3479(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;INTERACTION WITH PIK3R1
4.

"The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling."
Skolnik E.Y. , Lee C.-H. , Batzer A.G. , Vicentini L.M. , Zhou M. , Daly R.J. , Myers M.J. Jr. , Backer J.M. , Ullrich A. , White M.F. , Schlessinger J.
EMBO J.12:1929-1936(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2
5.

"Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1."
Sun X.-J. , Crimmins D.L. , Myers M.G. Jr. , Miralpeix M. , White M.F.
Mol. Cell. Biol.13:7418-7428(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-460; TYR-608; TYR-628; TYR-895; TYR-939; TYR-987; TYR-1172 AND TYR-1222
6.

"Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II."
Tanasijevic M.J. , Myers M.G. Jr. , Thoma R.S. , Crimmins D.L. , White M.F. , Sacks D.B.
J. Biol. Chem.268:18157-18166(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-99 AND THR-502
7.

"Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein."
Farhang-Fallah J. , Yin X. , Trentin G. , Cheng A.M. , Rozakis-Adcock M.
J. Biol. Chem.275:40492-40497(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PHIP;MUTAGENESIS OF TRP-106
8.

"Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action."
Aguirre V. , Werner E.D. , Giraud J. , Lee Y.H. , Shoelson S.E. , White M.F.
J. Biol. Chem.277:1531-1537(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-307
9.

"In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents."
Qiao L.Y. , Zhande R. , Jetton T.L. , Zhou G. , Sun X.-J.
J. Biol. Chem.277:26530-26539(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-789
10.

"Active Rho kinase (ROK-alpha) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells."
Begum N. , Sandu O.A. , Ito M. , Lohmann S.M. , Smolenski A.
J. Biol. Chem.277:6214-6222(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ROCK1;PHOSPHORYLATION

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