Protein name:
Integrin alpha-2 ;
Alternative:
Collagen receptor ;CD49 antigen-like family member B ;VLA-2 subunit alpha ;Platelet membrane glycoprotein Ia (GPIa) ;
CD:
CD49b ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.
Function:
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
PLQLVLVFSQ | GILNCCVAYN | VGLPKAKIFS | GPSSEQFGYA | VQQFINPKGN |
100:
WLLVGSPWSG | FPKNRMGDVY | KCPVDLSTTT | CEKLNLQTST | SMSNVTEMKT |
150:
NMSLGLTLTR | NVGTGGFLTC | GPLWAQQCGS | QYYTTGVCSD | VSPDFQLRTS |
200:
FAPAVQTCPS | FIDVVVVCDE | SNSIYPWDAV | KNFLEKFVQG | LDIGPTKTQM |
250:
GLIQYANNPR | VVFNLNTFKS | KDEMIKATSQ | TFQYGGDLTN | TFKAIQYARD |
300:
TAYSTAAGGR | PGATKVMVVV | TDGESHDGSK | LKAVIDQCNK | DNILRFGIAV |
350:
LGYLNRNALD | TKNLIKEIKA | IASIPTERHF | FNVSDEADLL | EKAGTIGEQI |
400:
FSIEGTVQGG | DNFQMEMSQV | GFSAEYSPQN | NILMLGAVGA | YDWSGTVVQK |
450:
TPHGHLIFSK | QAFEQILQDR | NHSSYLGYSV | ASISTGNSVH | FVAGAPRANY |
500:
TGQIVLYSVN | ENGNVTVIQS | QRGDQIGSYF | GSVLCAVDVN | KDTITDVLLV |
550:
GAPMYMNDLK | KEEGRVYLFT | ITKGILNWHQ | FLEGPNGLEN | ARFGSAIAAL |
600:
SDINMDGFND | VIVGSPLENQ | NSGAVYIYNG | HEGMIRLRYS | QKILGSDRAF |
650:
SSHLQYFGRS | LDGYGDLNGD | SITDVSVGAF | GQVVQLWSQS | IADVSVDASF |
700:
TPKKITLLNK | NAEIKLKLCF | SAKFRPTNQN | NQVAIVYNIT | IDEDQFSSRV |
750:
ISRGLFKENN | ERCLQKTMIV | SQAQRCSEYI | IHIQEPSDII | SPLNLCMNIS |
800:
LENPGTNPAL | EAYSETVKVF | SIPFHKDCGD | DGVCISDLVL | NVQQLPATQQ |
850:
QPFIVSNQNK | RLTFSVQLKN | KKESAYNTEI | VVDFSENLFF | ASWSMPVDGT |
900:
EVTCQIASSQ | KSVTCNVGYP | ALKSKQQVTF | TINFDFNLQN | LQNQASISFR |
950:
ALSESQEENM | ADNSVNLKLS | LLYDAEIHIT | RSTNINFYEV | SLDGNVSSVV |
1000:
HSFEDIGPKF | IFSIKVTTGS | VPVSMASVII | HIPQYTKDKN | PLMYLTGVHT |
1050:
DQAGDISCEA | EINPLKIGQT | SSSVSFKSEN | FRHIKELNCR | TASCSNIMCW |
1100:
LRDLQVKGEY | FLNVSTRIWN | GTFAASTFQT | VQLTAAAEID | TYNPQIYVIE |
1150:
ENTVTIPLTI | MKPHEKVEVP | TGVIVGSVIA | GILLLLALVA | ILWKLGFFKR |
1170:
KYEKMAKNPD | ETDETTELNS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
ELISA Kit for Bovine Integrin alpha-2
ELISA Kit for Bovine Integrin alpha-2
ELISA Kit for Bovine Integrin alpha-2
CLIA Kit for Bovine Integrin alpha-2
CLIA Kit for Bovine Integrin alpha-2
CLIA Kit for Bovine Integrin alpha-2
Polyclonal Antibody for Bovine Integrin alpha-2
Polyclonal Antibody for Bovine Integrin alpha-2
Polyclonal Antibody for Bovine Integrin alpha-2
Monoclonal Antibody for Bovine Integrin alpha-2
Monoclonal Antibody for Bovine Integrin alpha-2
Monoclonal Antibody for Bovine Integrin alpha-2
Protein for Bovine Integrin alpha-2
Protein for Bovine Integrin alpha-2
Protein for Bovine Integrin alpha-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]