Protein name:
Integrin alpha-L ;
Alternative:
Leukocyte adhesion glycoprotein LFA-1 alpha chain (LFA-1A) ;CD11 antigen-like family member A ;Leukocyte function-associated molecule 1 alpha chain ;
CD:
CD11a ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.
Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MKDSCITVMA | MALLSGFFFF | APASSYNLDV | RGARSFSPPR | AGRHFGYRVL |
100:
QVGNGVIVGA | PGEGNSTGSL | YQCQSGTGHC | LPVTLRGSNY | TSKYLGMTLA |
150:
TDPTDGSILA | CDPGLSRTCD | QNTYLSGLCY | LFRQNLQGPM | LQGRPGFQEC |
200:
IKGNVDLVFL | FDGSMSLQPD | EFQKILDFMK | DVMKKLSNTS | YQFAAVQFST |
250:
SYKTEFDFSD | YVKRKDPDAL | LKHVKHMLLL | TNTFGAINYV | ATEVFREELG |
300:
ARPDATKVLI | IITDGEATDS | GNIDAAKDII | RYIIGIGKHF | QTKESQETLH |
350:
KFASKPASEF | VKILDTFEKL | KDLFTELQKK | IYVIEGTSKQ | DLTSFNMELS |
400:
SSGISADLSR | GHAVVGAVGA | KDWAGGFLDL | KADLQDDTFI | GNEPLTPEVR |
450:
AGYLGYTVTW | LPSRQKTSLL | ASGAPRYQHM | GRVLLFQEPQ | GGGHWSQVQT |
500:
IHGTQIGSYF | GGELCGVDVD | QDGETELLLI | GAPLFYGEQR | GGRVFIYQRR |
550:
QLGFEEVSEL | QGDPGYPLGR | FGEAITALTD | INGDGLVDVA | VGAPLEEQGA |
600:
VYIFNGRHGG | LSPQPSQRIE | GTQVLSGIQW | FGRSIHGVKD | LEGDGLADVA |
650:
VGAESQMIVL | SSRPVVDMVT | LMSFSPAEIP | VHEVECSYST | SNKMKEGVNI |
700:
TICFQIKSLI | PQFQGRLVAN | LTYTLQLDGH | RTRRRGLFPG | GRHELRRNIA |
750:
VTTSMSCTDF | SFHFPVCVQD | LISPINVSLN | FSLWEEEGTP | RDQRAQGKDI |
800:
PPILRPSLHS | ETWEIPFEKN | CGEDKKCEAN | LRVSFSPARS | RALRLTAFAS |
850:
LSVELSLSNL | EEDAYWVQLD | LHFPPGLSFR | KVEMLKPHSQ | IPVSCEELPE |
900:
ESRLLSRALS | CNVSSPIFKA | GHSVALQMMF | NTLVNSSWGD | SVELHANVTC |
950:
NNEDSDLLED | NSATTIIPIL | YPINILIQDQ | EDSTLYVSFT | PKGPKIHQVK |
1000:
HMYQVRIQPS | IHDHNIPTLE | AVVGVPQPPS | EGPITHQWSV | QMEPPVPCHY |
1050:
EDLERLPDAA | EPCLPGALFR | CPVVFRQEIL | VQVIGTLELV | GEIEASSMFS |
1100:
LCSSLSISFN | SSKHFHLYGS | NASLAQVVMK | VDVVYEKQML | YLYVLSGIGG |
1150:
LLLLLLIFIV | LYKVGFFKRN | LKEKMEAGRG | VPNGIPAEDS | EQLASGQEAG |
1170:
DPGCLKPLHE | KDSESGGGKD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
ELISA Kit for Human Integrin alpha-L
ELISA Kit for Human Integrin alpha-L
ELISA Kit for Human Integrin alpha-L
CLIA Kit for Human Integrin alpha-L
CLIA Kit for Human Integrin alpha-L
CLIA Kit for Human Integrin alpha-L
Polyclonal Antibody for Human Integrin alpha-L
Polyclonal Antibody for Human Integrin alpha-L
Polyclonal Antibody for Human Integrin alpha-L
Monoclonal Antibody for Human Integrin alpha-L
Monoclonal Antibody for Human Integrin alpha-L
Monoclonal Antibody for Human Integrin alpha-L
Protein for Human Integrin alpha-L
Protein for Human Integrin alpha-L
Protein for Human Integrin alpha-L
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 155-331 IN COMPLEX WITH ICAM1